Search Results - "Dunn, Elyse"

The mechanism of catalysis by type-II NADH:quinone oxidoreductases by Blaza, James N., Bridges, Hannah R., Aragão, David, Dunn, Elyse A., Heikal, Adam, Cook, Gregory M., Nakatani, Yoshio, Hirst, Judy

“…Type II NADH:quinone oxidoreductase (NDH-2) is central to the respiratory chains of many organisms. It is not present in mammals so may be exploited as an…”
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Comparison of lipid and detergent enzyme environments for identifying inhibitors of membrane-bound energy-transducing proteins by Dunn, Elyse A., Cook, Gregory M., Heikal, Adam

“…This study compared detergent-solubilised (soluble) and lipid-reconstituted (proteoliposome) protein to establish a high-throughput method for identifying…”
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Incorporation of triphenylphosphonium functionality improves the inhibitory properties of phenothiazine derivatives in Mycobacterium tuberculosis by Dunn, Elyse A., Roxburgh, Marina, Larsen, Lesley, Smith, Robin A.J., McLellan, Alexander D., Heikal, Adam, Murphy, Michael P., Cook, Gregory M.

“…Tuberculosis (TB) is a difficult to treat disease caused by the bacterium Mycobacterium tuberculosis. The need for improved therapies is required to kill…”
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ALT control, delete: FANCM as an anti-cancer target in Alternative Lengthening of Telomeres by O'Rourke, Julienne J, Bythell-Douglas, Rohan, Dunn, Elyse A, Deans, Andrew J

“…Break-induced replication is a specific type of DNA repair that has a co-opted role in telomere extension by telomerase-negative cancer cells. This Alternative…”
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Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening by Dunn, Elyse A., Cook, Gregory M., Heikal, Adam

“…The energy-generating membrane protein NADH dehydrogenase (NDH-2), a proposed antibacterial drug target (see “Inhibitors of type II NADH:menaquinone…”
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Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation by Heikal, Adam, Nakatani, Yoshio, Dunn, Elyse, Weimar, Marion R., Day, Catherine L., Baker, Edward N., Lott, J. Shaun, Sazanov, Leonid A., Cook, Gregory M.

“…Summary Non‐proton pumping type II NADH dehydrogenase (NDH‐2) plays a central role in the respiratory metabolism of bacteria, and in the mitochondria of fungi,…”
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Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy by Xie, Stanley C, Metcalfe, Riley D, Dunn, Elyse, Morton, Craig J, Huang, Shih-Chung, Puhalovich, Tanya, Du, Yawei, Wittlin, Sergio, Nie, Shuai, Luth, Madeline R, Ma, Liting, Kim, Mi-Sook, Pasaje, Charisse Flerida A, Kumpornsin, Krittikorn, Giannangelo, Carlo, Houghton, Fiona J, Churchyard, Alisje, Famodimu, Mufuliat T, Barry, Daniel C, Gillett, David L, Dey, Sumanta, Kosasih, Clara C, Newman, William, Niles, Jacquin C, Lee, Marcus C S, Baum, Jake, Ottilie, Sabine, Winzeler, Elizabeth A, Creek, Darren J, Williamson, Nicholas, Parker, Michael W, Brand, Stephen, Langston, Steven P, Dick, Lawrence R, Griffin, Michael D W, Gould, Alexandra E, Tilley, Leann

“…Aminoacyl transfer RNA (tRNA) synthetases (aaRSs) are attractive drug targets, and we present class I and II aaRSs as previously unrecognized targets for…”
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Branchpoint translocation by fork remodelers as a general mechanism of R-loop removal by Hodson, Charlotte, van Twest, Sylvie, Dylewska, Malgorzata, O’Rourke, Julienne J., Tan, Winnie, Murphy, Vincent J., Walia, Mannu, Abbouche, Lara, Nieminuszczy, Jadwiga, Dunn, Elyse, Bythell-Douglas, Rohan, Heierhorst, Jörg, Niedzwiedz, Wojciech, Deans, Andrew J.

“…Co-transcriptional R loops arise from stalling of RNA polymerase, leading to the formation of stable DNA:RNA hybrids. Unresolved R loops promote genome…”
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Hijacking tRNA charging process: a novel approach to combat malaria by Ketprasit, Nutpakal, Xie, Stanley C., Dogovski, Con, Park, Joon Sung, Morton, Craig J., Hilko, David, Dunn, Elyse, Amini, Mona, Nie, Shuai, Williamson, Nicholas, Poulsen, Sally-Ann, Han, Byung Woo, Griffin, Michael D. W., Tilley, Leann

“…Abstract only…”
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Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions by Cook, Gregory M, Hards, Kiel, Dunn, Elyse, Heikal, Adam, Nakatani, Yoshio, Greening, Chris, Crick, Dean C, Fontes, Fabio L, Pethe, Kevin, Hasenoehrl, Erik, Berney, Michael

“…The emergence and spread of drug-resistant pathogens, and our inability to develop new antimicrobials to combat resistance, have inspired scientists to seek…”
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Reaction hijacking of tyrosine tRNA synthetase as a whole-of-life-cycle antimalarial strategy by Xie, Stanley C., Metcalfe, Riley D., Dunn, Elyse, Morton, Craig J., Huang, Shih-Chung, Puhalovich, Tanya, Du, Yawei, Wittlin, Sergio, Nie, Shuai, Luth, Madeline R., Ma, Liting, Kim, Mi-Sook, Pasaje, Charisse Flerida A., Kumpornsin, Krittikorn, Giannangelo, Carlo, Houghton, Fiona J., Churchyard, Alisje, Famodimu, Mufuliat T., Barry, Daniel C., Gillett, David L., Dey, Sumanta, Kosasih, Clara C., Newman, William, Niles, Jacquin C., Lee, Marcus C.S., Baum, Jake, Ottilie, Sabine, Winzeler, Elizabeth A., Creek, Darren J., Williamson, Nicholas, Parker, Michael W., Brand, Stephen L., Langston, Steven P., Dick, Lawrence R., Griffin, Michael D.W., Gould, Alexandra E., Tilley, Leann

“…Aminoacyl tRNA synthetases (aaRSs) are attractive drug targets. Here we show that class I and II aaRSs are previously unrecognized targets for AMP-mimicking…”
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Synthesis of diastereomeric, deoxy and ring-expanded sulfone analogues of aigialomycin D by Ting, Samuel Z.Y., Baird, Lynton J., Dunn, Elyse, Hanna, Reem, Leahy, Dora, Chan, Ariane, Miller, John H., Teesdale-Spittle, Paul H., Harvey, Joanne E.

“…Several analogues of the fungal natural product aigialomycin D (AmD) have been synthesised. These include the stereoisomer 5′R,6′S-AmD, 2,4-di-deoxyAmD,…”
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