Search Results - "Dunn, Deborah"

Immunoglobulin gene analysis as a tool for investigating human immune responses by Dunn‐Walters, Deborah, Townsend, Catherine, Sinclair, Emma, Stewart, Alex

“…Summary The human immunoglobulin repertoire is a hugely diverse set of sequences that are formed by processes of gene rearrangement, heavy and light chain gene…”
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Single-Cell Transcriptomic Analyses Define Distinct Peripheral B Cell Subsets and Discrete Development Pathways by Stewart, Alexander, Ng, Joseph Chi-Fung, Wallis, Gillian, Tsioligka, Vasiliki, Fraternali, Franca, Dunn-Walters, Deborah K

“…Separation of B cells into different subsets has been useful to understand their different functions in various immune scenarios. In some instances, the…”
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CD1d‐mediated lipid presentation by CD11c+ cells regulates intestinal homeostasis by Sáez de Guinoa, Julia, Jimeno, Rebeca, Gaya, Mauro, Kipling, David, Garzón, María José, Dunn‐Walters, Deborah, Ubeda, Carles, Barral, Patricia

“…Intestinal homeostasis relies on a continuous dialogue between the commensal bacteria and the immune system. Natural killer T (NKT) cells, which recognize…”
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Relationship of Workplace Incivility, Stress, and Burnout on Nurses’ Turnover Intentions and Psychological Empowerment by Oyeleye, Olubunmi, Hanson, Patricia, O’Connor, Nancy, Dunn, Deborah

“…This study explored the relationships among perceived workplace incivility, stress, burnout, perceived turnover intentions, and perceived level of…”
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Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity by Sabouri, Zahra, Schofield, Peter, Horikawa, Keisuke, Spierings, Emily, Kipling, David, Randall, Katrina L, Langley, David, Roome, Brendan, Vazquez-Lombardi, Rodrigo, Rouet, Romain, Hermes, Jana, Chan, Tyani D, Brink, Robert, Dunn-Walters, Deborah K, Christ, Daniel, Goodnow, Christopher C

“…The best-understood mechanisms for achieving antibody self/non-self discrimination discard self-reactive antibodies before they can be tested for binding…”
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High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations by Wu, Yu-Chang, Kipling, David, Leong, Hui Sun, Martin, Victoria, Ademokun, Alexander A., Dunn-Walters, Deborah K.

“…B-cell receptor (BCR) diversity is achieved centrally by rearrangement of Variable, Diversity, and Joining genes, and peripherally by somatic hypermutation and…”
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The relationship between CD27 negative and positive B cell populations in human peripheral blood by Wu, Yu-Chang Bryan, Kipling, David, Dunn-Walters, Deborah K

“…CD27 expression has been used to distinguish between memory and naive B cells in humans. However, low levels of mutated and isotype-switched CD27-IgD- cells…”
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B‐cell diversity decreases in old age and is correlated with poor health status by Gibson, Kate L., Wu, Yu‐Chang, Barnett, Yvonne, Duggan, Orla, Vaughan, Robert, Kondeatis, Elli, Nilsson, Bengt‐Olof, Wikby, Anders, Kipling, David, Dunn‐Walters, Deborah K.

“…Summary Older people suffer from a decline in immune system, which affects their ability to respond to infections and to raise efficient responses to vaccines…”
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Age-related aspects of human IgM+ B cell heterogeneity by Martin, Victoria, Wu, Yu-Chang, Kipling, David, Dunn-Walters, Deborah K.

“…The CD27+IgD+ B cell population, known as IgM memory, reduces with age. It is thought that this population is responsible for pneumococcal polysaccharide…”
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Vaccination‐induced changes in human B‐cell repertoire and pneumococcal IgM and IgA antibody at different ages by Ademokun, Alexander, Wu, Yu‐Chang, Martin, Victoria, Mitra, Rajive, Sack, Ulrich, Baxendale, Helen, Kipling, David, Dunn‐Walters, Deborah K.

“…Summary It is well known that older people are more susceptible to morbidity and mortality from infectious diseases, particularly from pulmonary diseases such…”
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Age-Related Changes in Human Peripheral Blood IGH Repertoire Following Vaccination by Wu, Yu-Chang Bryan, Kipling, David, Dunn-Walters, Deborah K

“…Immune protection against pulmonary infections, such as seasonal flu and invasive pneumonia, is severely attenuated with age, and vaccination regimes for the…”
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Editorial: New Insights Into B Cell Subsets in Health and Disease by Somers, Veerle, Dunn-Walters, Deborah K, van der Burg, Mirjam, Fraussen, Judith

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IgA-Producing Plasma Cells Originate From Germinal Centers That Are Induced by B-Cell Receptor Engagement in Humans by Barone, Francesca, Vossenkamper, Anna, Boursier, Laurent, Su, Wen, Watson, Alan, John, Susan, Dunn–Walters, Deborah K, Fields, Paul, Wijetilleka, Sonali, Edgeworth, Jonathan D, Spencer, Jo

“…Background & Aims IgA contributes to homeostatic balance between host and intestinal microbiota. Mechanisms that initiate the IgA response are unclear and…”
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Assessment of the Impact of an Endpoint Committee in the Ocular Hypertension Treatment Study by Gordon, Mae O., Higginbotham, Eve J., Heuer, Dale K., Parrish, Richard K., Robin, Alan L., Morris, Patricia A., Dunn, Deborah A., Wilson, Bradley S., Kass, Michael A.

“…To assess the impact of a masked Endpoint Committee on estimates of the incidence of primary open-angle glaucoma (POAG) treatment efficacy and statistical…”
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B cell profiles, antibody repertoire and reactivity reveal dysregulated responses with autoimmune features in melanoma by Crescioli, Silvia, Correa, Isabel, Ng, Joseph, Willsmore, Zena N., Laddach, Roman, Chenoweth, Alicia, Chauhan, Jitesh, Di Meo, Ashley, Stewart, Alexander, Kalliolia, Eleni, Alberts, Elena, Adams, Rebecca, Harris, Robert J., Mele, Silvia, Pellizzari, Giulia, Black, Anna B. M., Bax, Heather J., Cheung, Anthony, Nakamura, Mano, Hoffmann, Ricarda M., Terranova-Barberio, Manuela, Ali, Niwa, Batruch, Ihor, Soosaipillai, Antoninus, Prassas, Ioannis, Ulndreaj, Antigona, Chatanaka, Miyo K., Nuamah, Rosamund, Kannambath, Shichina, Dhami, Pawan, Geh, Jenny L. C., MacKenzie Ross, Alastair D., Healy, Ciaran, Grigoriadis, Anita, Kipling, David, Karagiannis, Panagiotis, Dunn-Walters, Deborah K., Diamandis, Eleftherios P., Tsoka, Sophia, Spicer, James, Lacy, Katie E., Fraternali, Franca, Karagiannis, Sophia N.

“…B cells are known to contribute to the anti-tumor immune response, especially in immunogenic tumors such as melanoma, yet humoral immunity has not been…”
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Significant Differences in Physicochemical Properties of Human Immunoglobulin Kappa and Lambda CDR3 Regions by Townsend, Catherine L, Laffy, Julie M J, Wu, Yu-Chang Bryan, Silva O'Hare, Joselli, Martin, Victoria, Kipling, David, Fraternali, Franca, Dunn-Walters, Deborah K

“…Antibody variable regions are composed of a heavy and a light chain, and in humans, there are two light chain isotypes: kappa and lambda. Despite their…”
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Reduced immunoglobulin gene diversity in patients with Cornelia de Lange syndrome by Björkman, Andrea, Du, Likun, van der Burg, Mirjam, Cormier-Daire, Valerie, Borck, Guntram, Pié, Juan, Anderlid, Britt-Marie, Hammarström, Lennart, Ström, Lena, de Villartay, Jean-Pierre, Kipling, David, Dunn Walters, Deborah, Pan-Hammarström, Qiang

“…The overall diversity of the IGHV repertoire, which is estimated by either the proportion of sequences with a unique complementary determining region 3 (CDR3)…”
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Transitional B Cells in Early Human B Cell Development - Time to Revisit the Paradigm? by Martin, Victoria G, Wu, Yu-Chang Bryan, Townsend, Catherine L, Lu, Grace H C, O'Hare, Joselli Silva, Mozeika, Alexander, Coolen, Anthonius C C, Kipling, David, Fraternali, Franca, Dunn-Walters, Deborah K

“…The B cell repertoire is generated in the adult bone marrow by an ordered series of gene rearrangement processes that result in massive diversity of…”
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Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus by Stewart, Alexander, Sinclair, Emma, Ng, Joseph Chi-Fung, O'Hare, Joselli Silva, Page, Audrey, Serangeli, Ilaria, Margreitter, Christian, Orsenigo, Federica, Longman, Katherine, Frampas, Cecile, Costa, Catia, Lewis, Holly-May, Kasar, Nora, Wu, Bryan, Kipling, David, Openshaw, Peter Jm, Chiu, Christopher, Baillie, J Kenneth, Scott, Janet T, Semple, Malcolm G, Bailey, Melanie J, Fraternali, Franca, Dunn-Walters, Deborah K

“…Immunoglobulin gene heterogeneity reflects the diversity and focus of the humoral immune response towards different infections, enabling inference of B cell…”
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Changes to the sebum lipidome upon COVID-19 infection observed via rapid sampling from the skin by Spick, Matt, Longman, Katherine, Frampas, Cecile, Lewis, Holly, Costa, Catia, Walters, Deborah Dunn, Stewart, Alex, Wilde, Michael, Greener, Danni, Evetts, George, Trivedi, Drupad, Barran, Perdita, Pitt, Andy, Bailey, Melanie

“…The COVID-19 pandemic has led to an unprecedented demand for testing - for diagnosis and prognosis - as well as for investigation into the impact of the…”
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