Search Results - "Dunn, Claire"

State-level Citizen Response to COVID-19 Containment Measures in Brazil and Mexico by Dunn, Claire, Laterzo, Isabel

“…In Brazil and Mexico, presidents failed to take swift, national action to stop the spread of COVID-19. Instead, the burden of imposing and enforcing public…”
Get full text

Correction: Jin et al. Comparative Evaluation of STEAP1 Targeting Chimeric Antigen Receptors with Different Costimulatory Domains and Spacers. Int. J. Mol. Sci. 2024, 25 , 586 by Jin, Yixin, Dunn, Claire, Persiconi, Irene, Sike, Adam, Skorstad, Gjertrud, Beck, Carole, Kyte, Jon Amund

“…In the original publication [...]…”
Get full text

Comparative Evaluation of STEAP1 Targeting Chimeric Antigen Receptors with Different Costimulatory Domains and Spacers by Jin, Yixin, Dunn, Claire, Persiconi, Irene, Sike, Adam, Skorstad, Gjertrud, Beck, Carole, Kyte, Jon Amund

“…We have developed a chimeric antigen receptor (CAR) against the six-transmembrane epithelial antigen of prostate-1 (STEAP1), which is expressed in prostate…”
Get full text

Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage by Dunn, Claire, Brunetto, Maurizia, Reynolds, Gary, Christophides, Theodoros, Kennedy, Patrick T, Lampertico, Pietro, Das, Abhishek, Lopes, A Ross, Borrow, Persephone, Williams, Kevin, Humphreys, Elizabeth, Afford, Simon, Adams, David H, Bertoletti, Antonio, Maini, Mala K

“…Hepatitis B virus (HBV) causes chronic infection in more than 350 million people worldwide. It replicates in hepatocytes but is non-cytopathic; liver damage is…”
Get full text

Development of STEAP1 targeting chimeric antigen receptor for adoptive cell therapy against cancer by Jin, Yixin, Lorvik, Kristina Berg, Jin, Yang, Beck, Carole, Sike, Adam, Persiconi, Irene, Kvaløy, Emilie, Saatcioglu, Fahri, Dunn, Claire, Kyte, Jon Amund

“…Chimeric antigen receptors (CARs) that retarget T cells against CD19 show clinical efficacy against B cell malignancies. Here, we describe the development of a…”
Get full text

Peripheral immune cells in metastatic breast cancer patients display a systemic immunosuppressed signature consistent with chronic inflammation by Chauhan, Sudhir Kumar, Dunn, Claire, Andresen, Nikolai Kragøe, Røssevold, Andreas Hagen, Skorstad, Gjertrud, Sike, Adam, Gilje, Bjørnar, Raj, Sunil Xavier, Huse, Kanutte, Naume, Bjørn, Kyte, Jon Amund

“…Immunotherapies blocking the PD-1/PD-L1 checkpoint show some efficacy in metastatic breast cancer (mBC) but are often hindered by immunosuppressive mechanisms…”
Get full text

Ipilimumab and nivolumab combined with anthracycline-based chemotherapy in metastatic hormone receptor-positive breast cancer: a randomized phase 2b trial by Andresen, Nikolai Kragøe, Røssevold, Andreas Hagen, Quaghebeur, Claire, Gilje, Bjørnar, Boge, Beate, Gombos, Andrea, Falk, Ragnhild Sørum, Mathiesen, Randi R., Julsrud, Lars, Garred, Øystein, Russnes, Hege G., Lereim, Ragnhild Reehorst, Chauhan, Sudhir Kumar, Lingjærde, Ole Christian, Dunn, Claire, Naume, Bjørn, Kyte, Jon Amund

“…BackgroundImmune checkpoint inhibitors have shown minimal clinical activity in hormone receptor-positive metastatic breast cancer (HR+mBC). Doxorubicin and…”
Get full text

Haemoproteus parasites and passerines: the effect of local generalists on inferences of host–parasite co-phylogeny in the British Isles by Woodrow, Charlie, Rosca, Adina Teodora, Fletcher, Rachel, Hone, Abigail, Ruta, Marcello, Hamer, Keith C., Dunn, Jenny Claire

“…Host–parasite associations provide a benchmark for investigating evolutionary arms races and antagonistic coevolution. However, potential ecological mechanisms…”
Get full text

Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines by Klein, Christian, Waldhauer, Inja, Nicolini, Valeria G., Freimoser-Grundschober, Anne, Nayak, Tapan, Vugts, Danielle J., Dunn, Claire, Bolijn, Marije, Benz, Jörg, Stihle, Martine, Lang, Sabine, Roemmele, Michaele, Hofer, Thomas, van Puijenbroek, Erwin, Wittig, David, Moser, Samuel, Ast, Oliver, Brünker, Peter, Gorr, Ingo H., Neumann, Sebastian, de Vera Mudry, Maria Cristina, Hinton, Heather, Crameri, Flavio, Saro, Jose, Evers, Stefan, Gerdes, Christian, Bacac, Marina, van Dongen, Guus, Moessner, Ekkehard, Umaña, Pablo

“…We developed cergutuzumab amunaleukin (CEA-IL2v, RG7813), a novel monomeric CEA-targeted immunocytokine, that comprises a single IL-2 variant (IL2v) moiety…”
Get full text

Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity by Dunn, Claire, Chalupny, N Jan, Sutherland, Claire L, Dosch, Stephanie, Sivakumar, P V, Johnson, David C, Cosman, David

“…The activating receptor, NKG2D, is expressed on a variety of immune effector cells and recognizes divergent families of major histocompatibility complex (MHC)…”
Get full text

Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection by Peppa, Dimitra, Micco, Lorenzo, Javaid, Alia, Kennedy, Patrick T F, Schurich, Anna, Dunn, Claire, Pallant, Celeste, Ellis, Gidon, Khanna, Pooja, Dusheiko, Geoffrey, Gilson, Richard J, Maini, Mala K

“…NK cells are enriched in the liver, constituting around a third of intrahepatic lymphocytes. We have previously demonstrated that they upregulate the death…”
Get full text

Subnational Politics and Redistribution in a Federal System: Determinants of Progressive Social Spending in Brazilian States by Dunn, Claire

“…Abstract What role do subnational governments play in shaping a country’s redistributive efforts? Existing literature suggests that federalism can be a…”
Get full text

Endogenous human cytomegalovirus gB is presented efficiently by MHC class II molecules to CD4+ CTL by Hegde, Nagendra R, Dunn, Claire, Lewinsohn, David M, Jarvis, Michael A, Nelson, Jay A, Johnson, David C

“…Human cytomegalovirus (HCMV) infects endothelial, epithelial, and glial cells in vivo. These cells can express MHC class II proteins, but are unlikely to play…”
Get full text

Novel Tumor-Targeted, Engineered IL-2 Variant (IL2v)-Based Immunocytokines For Immunotherapy Of Cancer by Klein, Christian, Waldhauer, Inja, Nicolini, Valeria, Dunn, Claire, Freimoser-Grundschober, Anne, Danny, Gerrits, Boerman, Otto, Nayak, Tapan, Herter, Sylvia, Van Puijenbroek, Erwin, Ast, Oliver, Hofer, Thomas, Hosse, Ralf, Lang, Sabine, Neumann, Sebastian, Kettenberger, Hubert, Neubauer, Markus, Gorr, Ingo, Tuerck, Dietrich, Evers, Stefan, Gerdes, Christian, Levitsky, Victor, Bacac, Marina, Moessner, Ekkehard, Umana, Pablo

“…IL-2 therapy can lead to durable responses in cancer patients, but is associated with significant toxicity. None of the known IL-2-based immunocytokines has…”
Get full text

Inhibition of HLA-DR Assembly, Transport, and Loading by Human Cytomegalovirus Glycoprotein US3: a Novel Mechanism for Evading Major Histocompatibility Complex Class II Antigen Presentation by Hegde, Nagendra R, Tomazin, Roman A, Wisner, Todd W, Dunn, Claire, Boname, Jessica M, Lewinsohn, David M, Johnson, David C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Inhibition of Glycolipid Shedding Rescues Recognition of a CD1+T Cell Lymphoma by Natural Killer T (NKT) Cells by Sriram, Venkataraman, Cho, Sungyoo, Li, Ping, O'Donnell, Patrick W., Dunn, Claire, Hayakawa, Kyoko, Blum, Janice S., Brutkiewicz, Randy R.

“…Neoplastic transformation of cells is accompanied by an aberration of cell surface glycolipid composition. These tumor-associated, altered glycosphingolipids…”
Get full text

Statistical investigation of simulated intestinal fluid composition on the equilibrium solubility of biopharmaceutics classification system class II drugs by Khadra, Ibrahim, Zhou, Zhou, Dunn, Claire, Wilson, Clive G., Halbert, Gavin

“…A drug’s solubility and dissolution behaviour within the gastrointestinal tract is a key property for successful administration by the oral route and one of…”
Get full text

Small scale design of experiment investigation of equilibrium solubility in simulated fasted and fed intestinal fluid by McPherson, Stephanie, Perrier, Jeremy, Dunn, Claire, Khadra, Ibrahim, Davidson, Scott, Ainousah, Bayan, Wilson, Clive G., Halbert, Gavin

“…[Display omitted] It is widely recognised that drug solubility within the gastrointestinal tract (GIT) differs from values determined in a simple aqueous…”
Get full text

CXCR6 marks a novel subset of T-betloEomeshi natural killer cells residing in human liver by Stegmann, Kerstin A., Robertson, Francis, Hansi, Navjyot, Gill, Upkar, Pallant, Celeste, Christophides, Theodoros, Pallett, Laura J., Peppa, Dimitra, Dunn, Claire, Fusai, Giuseppe, Male, Victoria, Davidson, Brian R., Kennedy, Patrick, Maini, Mala K.

“…Natural killer cells (NK) are highly enriched in the human liver, where they can regulate immunity and immunopathology. We probed them for a liver-resident…”
Get full text

Statistical investigation of the full concentration range of fasted and fed simulated intestinal fluid on the equilibrium solubility of oral drugs by Perrier, Jeremy, Zhou, Zhou, Dunn, Claire, Khadra, Ibrahim, Wilson, Clive G., Halbert, Gavin

“…Upon oral administration the solubility of a drug in intestinal fluid is a key property influencing bioavailability. It is also recognised that simple aqueous…”
Get full text