Search Results - "Dunlop, Rachael A"

Mechanisms of l-Serine-Mediated Neuroprotection Include Selective Activation of Lysosomal Cathepsins B and L by Dunlop, Rachael A., Carney, John M.

“…l -serine is a naturally occurring dietary amino acid that has recently received renewed attention as a potential therapy for the treatment of amyotrophic…”
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Oxidized proteins: Mechanisms of removal and consequences of accumulation by Dunlop, Rachael A., Brunk, Ulf T., Rodgers, Kenneth J.

“…Elevated levels of oxidized proteins are reported in diseased tissue from age‐related pathologies such as atherosclerosis, neurodegenerative disorders, and…”
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Kalata B1 Enhances Temozolomide Toxicity to Glioblastoma Cells by Gerlach, Samantha L, Metcalf, James S, Dunlop, Rachael A, Banack, Sandra Anne, Her, Cheenou, Krishnan, Viswanathan V, Göransson, Ulf, Gunasekera, Sunithi, Slazak, Blazej, Cox, Paul Alan

“…Glioblastoma (GBM) is the most aggressive cancer originating in the brain, but unfortunately combination treatments with resection, radiation, and chemotherapy…”
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Proteins containing oxidized amino acids induce apoptosis in human monocytes by Dunlop, Rachael A, Brunk, Ulf T, Rodgers, Kenneth J

“…Cellular deposits of oxidized and aggregated proteins are hallmarks of a variety of age-related disorders, but whether such proteins contribute to pathology is…”
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Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols by Zeng, Jingmin, Dunlop, Rachael A, Rodgers, Kenneth J, Davies, Michael J

“…Hyperglycaemia, triose phosphate decomposition and oxidation reactions generate reactive aldehydes in vivo. These compounds react non-enzymatically with…”
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The impact of specific oxidized amino acids on protein turnover in J774 cells by Dunlop, Rachael A, Dean, Roger T, Rodgers, Kenneth J

“…Oxidized protein deposition and accumulation have been implicated in the aetiology of a wide variety of age-related pathologies. Protein oxidation in vivo…”
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The Cyanotoxin and Non-protein Amino Acid β-Methylamino-L-Alanine (L-BMAA) in the Food Chain: Incorporation into Proteins and Its Impact on Human Health by Dunlop, Rachael A., Guillemin, Gilles J.

“…The size and frequency of cyanobacterial blooms are increasing concomitantly with rising global temperatures and increased eutrophication, and this has…”
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Cyclotides Chemosensitize Glioblastoma Cells to Temozolomide by Gerlach, Samantha L, Dunlop, Rachael A, Metcalf, James S, Banack, Sandra A, Cox, Paul Alan

“…Glioblastoma multiforme (GBM) is the most aggressive cancer originating in the brain, with a median survival of 12 months. Most patients do not respond to or…”
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Revisiting adverse reactions to vaccines: A critical appraisal of Autoimmune Syndrome Induced by Adjuvants (ASIA) by Hawkes, David, Benhamu, Joanne, Sidwell, Tom, Miles, Rhianna, Dunlop, Rachael A

“…Abstract In 2011 Shoenfeld and Agmon-Levin proposed a new syndrome as a way of grouping together a range of emerging autoimmune diseases with possible…”
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The use of l-serine to prevent β-methylamino-l-alanine (BMAA)-induced proteotoxic stress in vitro by Main, Brendan J., Dunlop, Rachael A., Rodgers, Kenneth J.

“…β-methylamino-l-alanine (BMAA), a non-protein amino acid synthesised by cyanobacteria, has been linked to a complex neurological disorder on Guam and more…”
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Calls by alternative medicine practitioners for vaccinated vs unvaccinated studies is not supported by evidence by Hawkes, David, Dunlop, Rachael A, Benhamu, Joanne

“…[...]it is probable that any studies of people who utilize these practitioners to the exclusion of appropriately qualified psychologists or medical…”
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Using an in vitro model to study oxidised protein accumulation in ageing fibroblasts by Shiozawa-West, Nae, Dunlop, Rachael A, Rodgers, Kenneth J

“…The accumulation of oxidised proteins in ageing cells and tissues results from an increase in oxidant damage coupled with impaired degradation of the damaged…”
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l-DOPA is incorporated into brain proteins of patients treated for Parkinson's disease, inducing toxicity in human neuroblastoma cells in vitro by Chan, Sandra W., Dunlop, Rachael A., Rowe, Anthony, Double, Kay L., Rodgers, Kenneth J.

“…Levodopa (l-dopa), a close structural analogue of the protein amino acid l-tyrosine, can substitute for l-tyrosine in protein synthesis and be mistakenly…”
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A microRNA diagnostic biomarker for amyotrophic lateral sclerosis by Banack, Sandra Anne, Dunlop, Rachael A, Mehta, Paul, Mitsumoto, Hiroshi, Wood, Stewart P, Han, Moon, Cox, Paul Alan

“…Abstract Blood-based diagnostic biomarkers for amyotrophic lateral sclerosis will improve patient outcomes and positively impact novel drug development…”
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The deleterious effects of non-protein amino acids from desert plants on human and animal health by Dunlop, Rachael A., Main, Brendan J., Rodgers, Kenneth J.

“…Since plants lack the ability to remove themselves from sites of predation, they have evolved alternative defences to keep predators at bay. Mechanical…”
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National Center for Complementary and Alternative Medicine-funded randomised controlled trials of acupuncture: a systematic review by Ernst, Edzard, Snyder, John, Dunlop, Rachael A

“…The work of the National Center for Complementary and Alternative Medicine (NCCAM) has repeatedly been criticised. Much of this criticism relates to the past…”
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Recent developments in the intracellular degradation of oxidized proteins by Dunlop, Rachael A, Rodgers, Kenneth J, Dean, Roger T

“…The accumulation of oxidized proteins in cells and tissues is a feature of a number of age-related diseases and may also occur as a result of the aging process…”
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Biosynthesis and turnover of DOPA-containing proteins by human cells by Rodgers, Kenneth J., Hume, Peter M., Dunlop, Rachael A., Dean, Roger T.

“…Protein-bound 3,4-dihydroxyphenylalanine (PB-DOPA) is a major product of hydroxyl radical attack on tyrosine residues of proteins. Levels of PB-DOPA in cells…”
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Evidence that DOPA-Derivatives are Generated After L-DOPA Incorporation into Proteins by Mammalian Cells by Thompson, Alisha M., Dunlop, Rachael A., Dean, Roger T., Rodgers, Kenneth J.

“…The adhesive and cohesive properties of the amino acid L-3,4-dihydroxyphenylalanine (DOPA) have been widely explored as a potential material for adhesion,…”
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Oxidative Bioactivation of Crotyl Alcohol to the Toxic Endogenous Aldehyde Crotonaldehyde:  Association of Protein Carbonylation with Toxicity in Mouse Hepatocytes by Fontaine, Frank R, Dunlop, Rachael A, Petersen, Dennis R, Burcham, Philip C

“…Recent confirmation that the toxic unsaturated aldehyde crotonaldehyde (CA) contributes to protein damage during lipid peroxidation confers interest on the…”
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