Implications of Foraging and Interspecies Interactions of Birds for Carriage of Escherichia coli Strains Resistant to Critically Important Antimicrobials
Globally, gulls have been associated with carriage of high levels of strains resistant to critically important antimicrobials (CIAs), a major concern, as these antimicrobials are the sole alternative or one among only a few alternatives available to treat severe life-threatening infections in humans...
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| Published in: | Applied and environmental microbiology Vol. 86; no. 20 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
American Society for Microbiology
01-10-2020
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Globally, gulls have been associated with carriage of high levels of
strains resistant to critically important antimicrobials (CIAs), a major concern, as these antimicrobials are the sole alternative or one among only a few alternatives available to treat severe life-threatening infections in humans. Previous studies of Australian silver gulls demonstrated high levels of resistance to CIAs, particularly fluoroquinolone and extended-spectrum cephalosporins, among
strains (carriage at 24% and 22%, respectively). This study aimed to identify and characterize strains from four distinct bird species inhabiting a common coastal environment, determine the frequency of carriage of CIA-resistant
strains, and examine if these resistant clones and their resistance-encoding mobile genetic elements (MGEs) could be transmitted between species. CIA-resistant
was detected in silver gulls (53%), little penguins (11%), and feral pigeons (10%), but not in bridled terns. In total, 37 different sequence types (STs) were identified, including clinically significant human-associated lineages, such as ST131, ST95, ST648, ST69, ST540, ST93, ST450, and ST10. Five main mobile genetic elements associated with
-positive
strains isolated from three bird species were detected. Examination of clonal lineages and MGEs provided indirect evidence of transfer of resistance between bird species. The carriage of CIA-resistant
by gulls and pigeons with proximity to humans, and in some instances food-producing animals, increases the likelihood of further bidirectional dissemination.
It has been shown that 20% of Australian silver gulls carry drug-resistant
strains of anthropogenic origin associated with severe diseases, such as sepsis and urinary tract infections, in humans. To further characterize the dynamics of drug-resistant
in wildlife populations, we investigated the carriage of critically important antimicrobial (CIA) drug-resistant
in four bird species in a common environment. Our results indicated that gulls, pigeons, and penguins carried drug-resistant
strains, and analysis of mobile genetic elements associated with resistance genes indicated interspecies resistance transfer. Terns, representing a bird species that forages on natural food sources at sea and distant from humans, did not test positive for drug-resistant
This study demonstrates carriage of CIA-resistant bacteria in multiple bird species living in areas commonly inhabited by humans and provides further evidence for a leapfrog effect of resistance in wildlife, facilitated by feeding habits. |
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| Bibliography: | Mark O’Dea and Sam Abraham contributed equally. Author order was determined both alphabetically by first name and in order of increasing seniority in the field. Citation Mukerji S, Gunasekera S, Dunlop JN, Stegger M, Jordan D, Laird T, Abraham RJ, Barton M, O’Dea M, Abraham S. 2020. Implications of foraging and interspecies interactions of birds for carriage of Escherichia coli strains resistant to critically important antimicrobials. Appl Environ Microbiol 86:e01610-20. https://doi.org/10.1128/AEM.01610-20. |
| ISSN: | 0099-2240 1098-5336 |
| DOI: | 10.1128/AEM.01610-20 |