Search Results - "Dunham, Stephen U."

Structural, Kinetic, and Thermodynamic Characterization of the Interconverting Isomers of MS-325, a Gadolinium(III)-Based Magnetic Resonance Angiography Contrast Agent by Tyeklár, Zoltán, Dunham, Stephen U, Midelfort, Katarina, Scott, Daniel M, Sajiki, Hirano, Ong, Karen, Lauffer, Randall B, Caravan, Peter, McMurry, Thomas J

“…The amphiphilic gadolinium complex MS-325 ((trisodium-{(2-(R)-[(4,4-diphenylcyclohexyl) phosphonooxymethyl] diethylenetriaminepentaacetato)…”
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The Interaction of MS-325 with Human Serum Albumin and Its Effect on Proton Relaxation Rates by Caravan, Peter, Cloutier, Normand J, Greenfield, Matthew T, McDermid, Sarah A, Dunham, Stephen U, Bulte, Jeff W. M, Amedio, John C, Looby, Richard J, Supkowski, Ronald M, Horrocks, William DeW, McMurry, Thomas J, Lauffer, Randall B

“…MS-325 is a novel blood pool contrast agent for magnetic resonance imaging currently undergoing clinical trials to assess blockage in arteries. MS-325…”
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Automated Solid-Phase Synthesis of Site-Specifically Platinated Oligodeoxyribonucleotides by Manchanda, Rajesh, Dunham, Stephen U, Lippard, Stephen J

“…Cisplatin, cis-diamminedichloroplatinum(II), has been effectively used to treat testicular and other cancers. DNA is a principal target for this drug, which…”
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When are Two Waters Worse Than One? Doubling the Hydration Number of a Gd-DTPA Derivative Decreases Relaxivity by Caravan, Peter, Amedio Jr, John C., Dunham, Stephen U., Greenfield, Matthew T., Cloutier, Normand J., McDermid, Sarah A., Spiller, Marga, Zech, Stephan G., Looby, Richard J., Raitsimring, Arnold M., McMurry, Thomas J., Lauffer, Randall B.

“…The synthesis of a novel ligand, based on N‐methyl‐diethylenetriaminetetraacetate and containing a diphenylcyclohexyl serum albumin binding group (L 1) is…”
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Solution Structure of a DNA Duplex Containing a Nitroxide Spin-Labeled Platinum d(GpG) Intrastrand Cross-Link Refined with NMR-Derived Long-Range Electron−Proton Distance Restraints by Dunham, Shari U, Dunham, Stephen U, Turner, Christopher J, Lippard, Stephen J

“…Modification of an undecamer deoxyribonucleotide, d(CTCTCGGTCTC), with the paramagnetic cisplatin analogue cis-[Pt(NH3)(4AT)ClI] afforded two orientational…”
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Long-Range Distance Constraints in Platinated Nucleotides: Structure Determination of the 5' Orientational Isomer of cis-[Pt(NH3)(4-aminoTEMPO){d(GpG)}]+ from Combined Paramagnetic and Diamagnetic NMR Constraints with Molecular Modeling by Dunham, Stephen U, Lippard, Stephen J

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A nuclear magnetic resonance investigation of water exchange reactions and trans to cis isomerization for diaqua and dihydroxobis(oxalato) and bis(malonato)platinum(IV) complexes by Dunham, Stephen U, Abbott, Edwin H

“…Dissociation of coordinated water from trans-diaquabisoxalatoplatinum(IV) has been proposed as the first step in the formation of one-dimensional mixed valence…”
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Isolation, Characterization, and DNA Binding Kinetics of Three Dirhodium(II,II) Carboxyamidate Complexes: Rh 2 (μ-L)(HNOCCF 3 ) 3 where L= [OOCCH 3 ] − , [OOCCF 3 ] − , or [HNOCCF 3 ] by Dunham, Shari U., Remaley, Todd S., Moore, Bryn S., Evans, Debra L., Dunham, Stephen U.

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Isolation, Characterization, and DNA Binding Kinetics of Three Dirhodium(II,II) Carboxyamidate Complexes: Rh2(μ-L)(HNOCCF3)3 where L= [OOCCH3]−, [OOCCF3]−, or [HNOCCF3] by Dunham, Shari U, Remaley, Todd S, Moore, Bryn S, Evans, Debra L, Dunham, Stephen U

“…Several transition metal compounds are effective antitumor drugs whose biological activity can be attributed to their ability to bind deoxyribonucleic acid…”
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MS-325: albumin-targeted contrast agent for MR angiography by Lauffer, R B, Parmelee, D J, Dunham, S U, Ouellet, H S, Dolan, R P, Witte, S, McMurry, T J, Walovitch, R C

“…To evaluate the protein-binding and signal enhancement characteristics of MS-325, a gadolinium-based magnetic resonance (MR) imaging blood pool agent that…”
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Cover Picture: When are Two Waters Worse Than One? Doubling the Hydration Number of a Gd-DTPA Derivative Decreases Relaxivity (Chem. Eur. J. 20/2005) by Caravan, Peter, Amedio Jr, John C., Dunham, Stephen U., Greenfield, Matthew T., Cloutier, Normand J., McDermid, Sarah A., Spiller, Marga, Zech, Stephan G., Looby, Richard J., Raitsimring, Arnold M., McMurry, Thomas J., Lauffer, Randall B.

“…MRI contrast agents act by relaxing water protons. When an acetate group on the MRI angiography contrast agent MS‐325 is replaced with a methyl group, it opens…”
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