Search Results - "Dunham, Shari U"

Covalent Binding and Interstrand Cross-Linking of Duplex DNA by Dirhodium(II,II) Carboxylate Compounds by Dunham, Shari U, Chifotides, Helen T, Mikulski, Szymon, Burr, Amity E, Dunbar, Kim R

“…The study of the interactions of double-stranded (ds) DNA with the dirhodium carboxylate compounds Rh2(O2CCH3)4(H2O)2 (Rh1), [Rh2(O2CCH3)2(CH3CN)6](BF4)2…”
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DNA sequence context modulates the impact of a cisplatin 1,2-d(GpG) intrastrand cross-link on the conformational and thermodynamic properties of duplex DNA by Pilch, Daniel S, Dunham, Shari U, Jamieson, Elizabeth R, Lippard, Stephen J, Breslauer, Kenneth J

“…The anticancer activity of cisplatin derives from its ability to bind and cross-link DNA, with the major adduct being the 1,2-d(GpG) intrastrand cross-link…”
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DNA Sequence Context and Protein Composition Modulate HMG-Domain Protein Recognition of Cisplatin-Modified DNA by Dunham, Shari U, Lippard, Stephen J

“…Proteins containing the high mobility group (HMG) DNA-binding domain form specific complexes with cisplatin-modified DNA which shield the major intrastrand…”
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Solution Structure of a DNA Duplex Containing a Nitroxide Spin-Labeled Platinum d(GpG) Intrastrand Cross-Link Refined with NMR-Derived Long-Range Electron−Proton Distance Restraints by Dunham, Shari U, Dunham, Stephen U, Turner, Christopher J, Lippard, Stephen J

“…Modification of an undecamer deoxyribonucleotide, d(CTCTCGGTCTC), with the paramagnetic cisplatin analogue cis-[Pt(NH3)(4AT)ClI] afforded two orientational…”
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DNA Sequence Context and Protein Composition Modulate HMG-Domain Protein Recognition of Cisplatin-Modified DNA by Dunham, Shari U, Lippard, Stephen J

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Isolation, Characterization, and DNA Binding Kinetics of Three Dirhodium(II,II) Carboxyamidate Complexes: Rh 2 (μ-L)(HNOCCF 3 ) 3 where L= [OOCCH 3 ] − , [OOCCF 3 ] − , or [HNOCCF 3 ] by Dunham, Shari U., Remaley, Todd S., Moore, Bryn S., Evans, Debra L., Dunham, Stephen U.

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Isolation, Characterization, and DNA Binding Kinetics of Three Dirhodium(II,II) Carboxyamidate Complexes: Rh2(μ-L)(HNOCCF3)3 where L= [OOCCH3]−, [OOCCF3]−, or [HNOCCF3] by Dunham, Shari U, Remaley, Todd S, Moore, Bryn S, Evans, Debra L, Dunham, Stephen U

“…Several transition metal compounds are effective antitumor drugs whose biological activity can be attributed to their ability to bind deoxyribonucleic acid…”
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Influence of Cisplatin Intrastrand Crosslinking on the Conformation, Thermal Stability, and Energetics of a 20-mer DNA Duplex by Poklar, Natas̆a, Pilch, Daniel S., Lippard, Stephen J., Redding, Elizabeth A., Dunham, Shari U., Breslauer, Kenneth J.

“…cis-Diamminedichloroplatinum(II) (cisplatin) is a widely used anticancer drug that binds to and crosslinks DNA. The major DNA adduct of the drug results from…”
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