Search Results - "Dunham, Richard M."

Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques by Vujkovic-Cvijin, Ivan, Swainson, Louise A., Chu, Simon N., Ortiz, Alexandra M., Santee, Clark A., Petriello, Annalise, Dunham, Richard M., Fadrosh, Douglas W., Lin, Din L., Faruqi, Ali A., Huang, Yong, Apetrei, Cristian, Pandrea, Ivona, Hecht, Frederick M., Pilcher, Christopher D., Klatt, Nichole R., Brenchley, Jason M., Lynch, Susan V., McCune, Joseph M.

“…Gut microbes can profoundly modulate mucosal barrier-promoting Th17 cells in mammals. A salient feature of HIV/simian immunodeficiency virus (SIV)…”
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The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized crossover trial by Somsouk, Ma, Dunham, Richard M, Cohen, Michelle, Albright, Rebecca, Abdel-Mohsen, Mohamed, Liegler, Teri, Lifson, Jeffrey, Piatak, Michael, Gorelick, Robert, Huang, Yong, Wu, Yuaner, Hsue, Priscilla Y, Martin, Jeffrey N, Deeks, Steven G, McCune, Joseph M, Hunt, Peter W

“…The anti-inflammatory agent, mesalamine (5-aminosalicylic acid) has been shown to decrease mucosal inflammation in ulcerative colitis. The effect of mesalamine…”
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Dynamics of Simian Immunodeficiency Virus SIVmac239 Infection in Pigtail Macaques by KLATT, Nlchole R, CANARY, Lauren A, SILVESTRI, Guido, BRENCHLEY, Jason M, VANDERFORD, Thomas H, VINTON, Caroi L, ENGRAM, Jessica C, DUNHAM, Richard M, CRONISE, Heather E, SWERCZEK, Joanna M, LAFONT, Bernard A. P, PICKER, Louis J

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IFN-α blockade during ART-treated SIV infection lowers tissue vDNA, rescues immune function, and improves overall health by Swainson, Louise A, Sharma, Ashish Arunkumar, Ghneim, Khader, Ribeiro, Susan Pereira, Wilkinson, Peter, Dunham, Richard M, Albright, Rebecca G, Wong, Samson, Estes, Jacob D, Piatak, Michael, Deeks, Steven G, Hunt, Peter W, Sekaly, Rafick-Pierre, McCune, Joseph M

“…Type I IFNs (TI-IFNs) drive immune effector functions during acute viral infections and regulate cell cycling and systemic metabolism. That said, chronic…”
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Short-Lived Infected Cells Support Virus Replication in Sooty Mangabeys Naturally Infected with Simian Immunodeficiency Virus: Implications for AIDS Pathogenesis by GORDON, Shari N, DUNHAM, Richard M, HA YOUN LEE, HAASE, Ashley T, MILLER, Michael D, KAUR, Amitinder, STAPRANS, Silvija I, PERELSON, Alan S, FEINBERG, Mark B, SILVESTRI, Guido, ENGRAM, Jessica C, ESTES, Jacob, ZICHUN WANG, KLATT, Nichole R, PAIARDINI, Mirko, PANDREA, Ivona V, APETREI, Cristian, SODORA, Donald L

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Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques by Vanderford, Thomas H, Bleckwehl, Chelsea, Engram, Jessica C, Dunham, Richard M, Klatt, Nichole R, Feinberg, Mark B, Garber, David A, Betts, Michael R, Silvestri, Guido

“…SIV(mac239) infection of rhesus macaques (RMs) results in AIDS despite the generation of a strong antiviral cytotoxic T lymphocyte (CTL) response, possibly due…”
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Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism by Vujkovic-Cvijin, Ivan, Dunham, Richard M, Iwai, Shoko, Maher, Michael C, Albright, Rebecca G, Broadhurst, Mara J, Hernandez, Ryan D, Lederman, Michael M, Huang, Yong, Somsouk, Ma, Deeks, Steven G, Hunt, Peter W, Lynch, Susan V, McCune, Joseph M

“…Progressive HIV infection is characterized by dysregulation of the intestinal immune barrier, translocation of immunostimulatory microbial products, and…”
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Glucagon‐like peptide‐1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway by Gupta, Nitika Arora, Mells, Jamie, Dunham, Richard M., Grakoui, Arash, Handy, Jeffrey, Saxena, Neeraj Kumar, Anania, Frank A.

“…Glucagon‐like peptide 1 (GLP‐1) is a naturally occurring peptide secreted by the L cells of the small intestine. GLP‐1 functions as an incretin and stimulates…”
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Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo by Nixon, Christopher C., Mavigner, Maud, Sampey, Gavin C., Brooks, Alyssa D., Spagnuolo, Rae Ann, Irlbeck, David M., Mattingly, Cameron, Ho, Phong T., Schoof, Nils, Cammon, Corinne G., Tharp, Greg K., Kanke, Matthew, Wang, Zhang, Cleary, Rachel A., Upadhyay, Amit A., De, Chandrav, Wills, Saintedym R., Falcinelli, Shane D., Galardi, Cristin, Walum, Hasse, Schramm, Nathaniel J., Deutsch, Jennifer, Lifson, Jeffrey D., Fennessey, Christine M., Keele, Brandon F., Jean, Sherrie, Maguire, Sean, Liao, Baolin, Browne, Edward P., Ferris, Robert G., Brehm, Jessica H., Favre, David, Vanderford, Thomas H., Bosinger, Steven E., Jones, Corbin D., Routy, Jean-Pierre, Archin, Nancie M., Margolis, David M., Wahl, Angela, Dunham, Richard M., Silvestri, Guido, Chahroudi, Ann, Garcia, J. Victor

“…Long-lasting, latently infected resting CD4 + T cells are the greatest obstacle to obtaining a cure for HIV infection, as these cells can persist despite…”
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Gut epithelial barrier and systemic inflammation during chronic HIV infection by Somsouk, Ma, Estes, Jacob D, Deleage, Claire, Dunham, Richard M, Albright, Rebecca, Inadomi, John M, Martin, Jeffrey N, Deeks, Steven G, McCune, Joseph M, Hunt, Peter W

“…Microbial translocation and innate immune action characterize HIV infection. Continued gut mucosal dysfunction during treatment and its relationship to CD4…”
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DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors by Kazmierski, Wieslaw M, Xia, Bing, Miller, John, De la Rosa, Martha, Favre, David, Dunham, Richard M, Washio, Yoshiaki, Zhu, Zhengrong, Wang, Feng, Mebrahtu, Makda, Deng, Hongfeng, Basilla, Jonathan, Wang, Liping, Evindar, Ghotas, Fan, Lijun, Olszewski, Alison, Prabhu, Ninad, Davie, Christopher, Messer, Jeffrey A, Samano, Vicente

“…We report the discovery of a novel indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor class through the affinity selection of a previously unreported indole-based…”
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Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid by Dunham, Richard M, Thapa, Manoj, Velazquez, Victoria M, Elrod, Elizabeth J, Denning, Timothy L, Pulendran, Bali, Grakoui, Arash

“…The liver has long been described as immunosuppressive, although the mechanisms underlying this phenomenon are incompletely understood. Hepatic stellate cells…”
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SMAC Mimetic Plus Triple-Combination Bispecific HIVxCD3 Retargeting Molecules in SHIV.C.CH505-Infected, Antiretroviral Therapy-Suppressed Rhesus Macaques by Dashti, Amir, Waller, Chevaughn, Mavigner, Maud, Schoof, Nils, Bar, Katharine J, Shaw, George M, Vanderford, Thomas H, Liang, Shan, Lifson, Jeffrey D, Dunham, Richard M, Ferrari, Guido, Tuyishime, Marina, Lam, Chia-Ying K, Nordstrom, Jeffrey L, Margolis, David M, Silvestri, Guido, Chahroudi, Ann

“…The "shock-and-kill" human immunodeficiency virus type 1 (HIV-1) cure strategy involves latency reversal followed by immune-mediated clearance of infected…”
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AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques by Dashti, Amir, Sukkestad, Sophia, Horner, Anna M., Neja, Margaret, Siddiqi, Zain, Waller, Chevaughn, Goldy, Jordan, Monroe, Dominique, Lin, Alice, Schoof, Nils, Singh, Vidisha, Mavigner, Maud, Lifson, Jeffrey D., Deleage, Claire, Tuyishime, Marina, Falcinelli, Shane D., King, Hannah A. D., Ke, Ruian, Mason, Rosemarie D., Archin, Nancie M., Dunham, Richard M., Safrit, Jeffrey T., Jean, Sherrie, Perelson, Alan S., Margolis, David M., Ferrari, Guido, Roederer, Mario, Silvestri, Guido, Chahroudi, Ann

“…The main barrier to HIV cure is a persistent reservoir of latently infected CD4 + T cells harboring replication-competent provirus that fuels rebound viremia…”
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IL-7 administration drives T cell–cycle entry and expansion in HIV-1 infection by Sereti, Irini, Dunham, Richard M., Spritzler, John, Aga, Evgenia, Proschan, Michael A., Medvik, Kathy, Battaglia, Catherine A., Landay, Alan L., Pahwa, Savita, Fischl, Margaret A., Asmuth, David M., Tenorio, Allan R., Altman, John D., Fox, Lawrence, Moir, Susan, Malaspina, Angela, Morre, Michel, Buffet, Renaud, Silvestri, Guido, Lederman, Michael M.

“…Interleukin 7 (IL-7) is a common gamma chain receptor cytokine implicated in thymopoiesis and in peripheral expansion and survival of T lymphocytes. The safety…”
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CD8 Lymphocyte Depletion Enhances the Latency Reversal Activity of the SMAC Mimetic AZD5582 in ART-Suppressed Simian Immunodeficiency Virus-Infected Rhesus Macaques by Mavigner, Maud, Liao, Laura E, Brooks, Alyssa D, Ke, Ruian, Mattingly, Cameron, Schoof, Nils, McBrien, Julia, Carnathan, Diane, Liang, Shan, Vanderford, Thomas H, Paiardini, Mirko, Kulpa, Deanna, Lifson, Jeffrey D, Dunham, Richard M, Easley, Kirk A, Margolis, David M, Perelson, Alan S, Silvestri, Guido, Chahroudi, Ann

“…Inducing latency reversal to reveal infected cells to the host immune system represents a potential strategy to cure human immunodeficiency virus (HIV)…”
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Altered Response Pattern following AZD5582 Treatment of SIV-Infected, ART-Suppressed Rhesus Macaque Infants by Bricker, Katherine M, Obregon-Perko, Veronica, Williams, Brianna, Oliver, Danielle, Uddin, Ferzan, Neja, Margaret, Hopkins, Louis, Dashti, Amir, Jean, Sherrie, Wood, Jennifer S, Ehnert, Stephanie, Liang, Shan, Vanderford, Thomas, Tharp, Gregory K, Bosinger, Steven E, Schauer, Amanda P, Mavigner, Maud, Cottrell, Mackenzie L, Margolis, David, Dunham, Richard M, Chahroudi, Ann

“…The "shock and kill" strategy for HIV-1 cure incorporates latency-reversing agents (LRA) in combination with interventions that aid the host immune system in…”
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PD-1 tempers Tregs in chronic HCV infection by Radziewicz, Henry, Dunham, Richard M, Grakoui, Arash

“…Adaptive T cell responses are critical for controlling infections with viruses such as HIV, HBV, and HCV. However, these responses must be carefully regulated…”
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Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo by Falcinelli, Shane D, Peterson, Jackson J, Turner, Anne-Marie W, Irlbeck, David, Read, Jenna, Raines, Samuel Lm, James, Katherine S, Sutton, Cameron, Sanchez, Anthony, Emery, Ann, Sampey, Gavin, Ferris, Robert, Allard, Brigitte, Ghofrani, Simon, Kirchherr, Jennifer L, Baker, Caroline, Kuruc, JoAnn D, Gay, Cynthia L, James, Lindsey I, Wu, Guoxin, Zuck, Paul, Rioja, Inmaculada, Furze, Rebecca C, Prinjha, Rab K, Howell, Bonnie J, Swanstrom, Ronald, Browne, Edward P, Strahl, Brian D, Dunham, Richard M, Archin, Nancie M, Margolis, David M

“…Latency reversal strategies for HIV cure using inhibitor of apoptosis protein (IAP) antagonists (IAPi) induce unprecedented levels of latent reservoir…”
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Severe Depletion of Mucosal CD4+ T Cells in AIDS-Free Simian Immunodeficiency Virus-Infected Sooty Mangabeys by Gordon, Shari N, Klatt, Nichole R, Bosinger, Steven E, Brenchley, Jason M, Milush, Jeffrey M, Engram, Jessica C, Dunham, Richard M, Paiardini, Mirko, Klucking, Sara, Danesh, Ali, Strobert, Elizabeth A, Apetrei, Cristian, Pandrea, Ivona V, Kelvin, David, Douek, Daniel C, Staprans, Silvija I, Sodora, Donald L, Silvestri, Guido

“…HIV-infected humans and SIV-infected rhesus macaques experience a rapid and dramatic loss of mucosal CD4+ T cells that is considered to be a key determinant of…”
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