Search Results - "Dunger, D."

Banting Memorial Lecture 2016 Reducing lifetime risk of complications in adolescents with Type 1 diabetes by Dunger, D. B.

“…Adolescence is a challenging period of life for any young person, and for those with Type 1 diabetes, physiological and psychological factors can result in a…”
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The effects of gestational diabetes mellitus on fetal growth and neonatal birth measures in an African cohort by Macaulay, S., Munthali, R. J., Dunger, D. B., Norris, S. A.

“…Aim Fetal exposure to gestational diabetes mellitus (GDM) is said to alter fetal growth and increase the risk of macrosomia. However, little research on GDM…”
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The descriptive epidemiology of congenital and acquired cryptorchidism in a UK infant cohort by Acerini, C L, Miles, H L, Dunger, D B, Ong, K K, Hughes, I A

“…Introduction: Recent studies in other European countries suggest that the prevalence of congenital cryptorchidism continues to increase. This study aimed to…”
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Longitudinal changes in insulin sensitivity and secretion from birth to age three years in small- and appropriate-for-gestational-age children by MERICQ, V, ONG, K. K, BAZAES, R, PENA, V, AVILA, A, SALAZAR, T, SOTO, N, IBIGUEZ, G, DUNGER, D. B

“…Insulin resistance and type 2 diabetes risk in human subjects who were small-for-gestational-age (SGA) at birth may be a consequence of rapid early postnatal…”
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Home Use of an Artificial Beta Cell in Type 1 Diabetes by Thabit, Hood, Tauschmann, Martin, Allen, Janet M, Leelarathna, Lalantha, Hartnell, Sara, Wilinska, Malgorzata E, Acerini, Carlo L, Dellweg, Sibylle, Benesch, Carsten, Heinemann, Lutz, Mader, Julia K, Holzer, Manuel, Kojzar, Harald, Exall, Jane, Yong, James, Pichierri, Jennifer, Barnard, Katharine D, Kollman, Craig, Cheng, Peiyao, Hindmarsh, Peter C, Campbell, Fiona M, Arnolds, Sabine, Pieber, Thomas R, Evans, Mark L, Dunger, David B, Hovorka, Roman

“…In two randomized trials conducted under home conditions, investigators compared closed-loop insulin delivery with sensor-augmented pump therapy in adults and…”
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Prenatal paracetamol exposure is associated with shorter anogenital distance in male infants by Fisher, B.G., Thankamony, A., Hughes, I.A., Ong, K.K., Dunger, D.B., Acerini, C.L.

“…STUDY QUESTION What is the relationship between maternal paracetamol intake during the masculinisation programming window (MPW, 8–14 weeks of gestation) and…”
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The relationship between Insulin-like Growth Factor 1, sex steroids and timing of the pubertal growth spurt by Cole, T.J., Ahmed, M.L., Preece, M.A., Hindmarsh, P., Dunger, D.B.

“…Summary Objective Progress through puberty involves a complex hormonal cascade, but the individual contributions of hormones, particularly IGF‐1, are unknown…”
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Maternal serum concentrations of bisphenol A and propyl paraben in early pregnancy are associated with male infant genital development by Fisher, B G, Thankamony, A, Mendiola, J, Petry, C J, Frederiksen, H, Andersson, A M, Juul, A, Ong, K K, Dunger, D B, Hughes, I A, Acerini, C L

“…Abstract STUDY QUESTION Are maternal serum phthalate metabolite, phenol and paraben concentrations measured at 10–17 weeks of gestation associated with male…”
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GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults by Allen, D B, Backeljauw, P, Bidlingmaier, M, Biller, B M K, Boguszewski, M, Burman, P, Butler, G, Chihara, K, Christiansen, J, Cianfarani, S, Clayton, P, Clemmons, D, Cohen, P, Darendeliler, F, Deal, C, Dunger, D, Erfurth, E M, Fuqua, J S, Grimberg, A, Haymond, M, Higham, C, Ho, K, Hoffman, A R, Hokken-Koelega, A, Johannsson, G, Juul, A, Kopchick, J, Lee, P, Pollak, M, Radovick, S, Robison, L, Rosenfeld, R, Ross, R J, Savendahl, L, Saenger, P, Toft Sorensen, H, Stochholm, K, Strasburger, C, Swerdlow, A, Thorner, M

“…Recombinant human GH (rhGH) has been in use for 30 years, and over that time its safety and efficacy in children and adults has been subject to considerable…”
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Pathophysiology of postprandial hyperglycaemia in women with type 1 diabetes during pregnancy by Murphy, H. R., Elleri, D., Allen, J. M., Harris, J., Simmons, D., Rayman, G., Temple, R. C., Umpleby, A. M., Dunger, D. B., Haidar, A., Nodale, M., Wilinska, M. E., Hovorka, R.

“…Aims/hypothesis Although maternal hyperglycaemia is associated with increased risk of adverse pregnancy outcome, the mechanisms of postprandial hyperglycaemia…”
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First UK survey of paediatric type 2 diabetes and MODY by Ehtisham, S, Hattersley, A T, Dunger, D B, Barrett, T G

“…Aims: To estimate the UK prevalence of childhood type 2 diabetes and maturity onset diabetes of the young (MODY), and distinguish them from each other and from…”
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Monitoring of concordance in growth hormone therapy by Kapoor, R R, Burke, S A, Sparrow, S E, Hughes, I A, Dunger, D B, Ong, K K, Acerini, C L

“…Concordance with growth hormone (GH) therapy in 75 children was objectively assessed using data on GP prescriptions over 12 months. 23% missed >2…”
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The risk and outcome of cerebral oedema developing during diabetic ketoacidosis by Edge, J A, Hawkins, M M, Winter, D L, Dunger, D B

“…BACKGROUND Cerebral oedema is a major cause of morbidity and mortality in children with insulin dependent diabetes. AIMS To determine the risk and outcome of…”
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Even transient rapid infancy weight gain is associated with higher BMI in young adults and earlier menarche by Salgin, B, Norris, S A, Prentice, P, Pettifor, J M, Richter, L M, Ong, K K, Dunger, D B

“…Background: Early postnatal rapid ‘catch-up’ weight gain has been consistently associated with subsequent higher obesity risk and earlier pubertal development…”
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ESPE/LWPES consensus statement on diabetic ketoacidosis in children and adolescents by Dunger, D B, Sperling, M A, Acerini, C L, Bohn, D J, Daneman, D, Danne, T P A, Glaser, N S, Hanas, R, Hintz, R L, Levitsky, L L, Savage, M O, Tasker, R C, Wolfsdorf, J I

“…Diabetic ketoacidosis (DKA) is the leading cause of morbidity and mortality in children with type 1 diabetes mellitus (TIDM). Mortality is predominantly…”
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The UK case-control study of cerebral oedema complicating diabetic ketoacidosis in children by EDGE, J. A, JAKES, R. W, ROY, Y, HAWKINS, M, WINTER, D, FORD-ADAMS, M. E, MURPHY, N. P, BERGOMI, A, WIDMER, B, DUNGER, D. B

“…Cerebral oedema complicating diabetic ketoacidosis (DKA) remains the major cause of morbidity and mortality in children with type 1 diabetes, but its aetiology…”
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Absorption patterns of meals containing complex carbohydrates in type 1 diabetes by Elleri, D., Allen, J. M., Harris, J., Kumareswaran, K., Nodale, M., Leelarathna, L., Acerini, C. L., Haidar, A., Wilinska, M. E., Jackson, N., Umpleby, A. M., Evans, M. L., Dunger, D. B., Hovorka, R.

“…Aims/hypothesis Successful postprandial glycaemia management requires understanding of absorption patterns after meals containing variable complex…”
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Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels by ONG, K. K, PETRY, C. J, EMMETT, P. M, SANDHU, M. S, KIESS, W, HALES, C. N, NESS, A. R, DUNGER, D. B

“…Type 2 diabetes risk is associated with low birth weight, rapid weight gain during childhood, and shorter stature and lower circulating IGF-I levels in adults…”
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Which infancy growth parameters are associated with later adiposity? The Cambridge Baby Growth Study by Ong, Ken K., Cheng, Tuck Seng, Olga, L., Prentice, P. M., Petry, C. J., Hughes, I. A., Dunger, D. B.

“…Background: Highly consistent positive associations are reported between infancy growth and later obesity risk. However, it is unclear whether infancy growth…”
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β‐cell specific T‐lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults by Arif, S., Gibson, V. B., Nguyen, V., Bingley, P. J., Todd, J. A., Guy, C., Dunger, D. B., Dayan, C. M., Powrie, J., Lorenc, A., Peakman, M.

“…Aim To examine the hypothesis that the quality, magnitude and breadth of helper T‐lymphocyte responses to β cells differ in Type 1 diabetes according to…”
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