Search Results - "Dunaev, Pavel"

A Novel Receptor Tyrosine Kinase Switch Promotes Gastrointestinal Stromal Tumor Drug Resistance by Boichuk, Sergei, Galembikova, Aigul, Dunaev, Pavel, Valeeva, Elena, Shagimardanova, Elena, Gusev, Oleg, Khaiboullina, Svetlana

“…The fact that most gastrointestinal stromal tumors (GISTs) acquire resistance to imatinib (IM)-based targeted therapy remains the main driving force to…”
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The Design, Synthesis, and Biological Activities of Pyrrole-Based Carboxamides: The Novel Tubulin Inhibitors Targeting the Colchicine-Binding Site by Boichuk, Sergei, Galembikova, Aigul, Syuzov, Kirill, Dunaev, Pavel, Bikinieva, Firuza, Aukhadieva, Aida, Zykova, Svetlana, Igidov, Nazim, Gankova, Ksenia, Novikova, Maria, Kopnin, Pavel

“…Microtubule targeting agents (MTAs) that interfere with the dynamic state of the mitotic spindle are well-known and effective chemotherapeutic agents. These…”
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2-APCAs, the Novel Microtubule Targeting Agents Active Against Distinct Cancer Cell Lines by Boichuk, Sergei, Galembikova, Aigul, Bikinieva, Firuza, Dunaev, Pavel, Aukhadieva, Aida, Syuzov, Kirill, Zykova, Svetlana, Igidov, Nazim, Ksenofontov, Alexander, Bocharov, Pavel

“…Microtubules are known as the most attractive molecular targets for anti-cancer drugs. However, the number of serious limitations of the microtubule targeting…”
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Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair by Boichuk, Sergei, Bikinieva, Firuza, Nurgatina, Ilmira, Dunaev, Pavel, Valeeva, Elena, Aukhadieva, Aida, Sabirov, Alexey, Galembikova, Aigul

“…Activation of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway is well documented for a broad spectrum of human malignancies supporting their growth and…”
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Imbalance between Actin Isoforms Contributes to Tumour Progression in Taxol-Resistant Triple-Negative Breast Cancer Cells by Dugina, Vera, Vasileva, Maria, Khromova, Natalia, Vinokurova, Svetlana, Shagieva, Galina, Mikheeva, Ekaterina, Galembikova, Aigul, Dunaev, Pavel, Kudlay, Dmitry, Boichuk, Sergei, Kopnin, Pavel

“…The widespread occurrence of breast cancer and its propensity to develop drug resistance highlight the need for a comprehensive understanding of the molecular…”
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Targeting of FGF-Signaling Re-Sensitizes Gastrointestinal Stromal Tumors (GIST) to Imatinib In Vitro and In Vivo by Boichuk, Sergei, Galembikova, Aigul, Dunaev, Pavel, Micheeva, Ekaterina, Valeeva, Elena, Novikova, Maria, Khromova, Natalya, Kopnin, Pavel

“…Dysregulation of the fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR) signaling pathway is frequently observed in multiple human…”
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A novel terpene-BODIPY conjugates based fluorescent probes: Synthesis, spectral properties, stability, penetration efficiency into bacterial, fungal and mammalian cells by Guseva, Galina B., Eremeeva, Yuliya V., Ksenofontov, Alexander A., Antina, Elena V., Gilfanov, Ilmir R., Lisovskaya, Svetlana A., Trizna, Elena Y., Kayumov, Airat R., Babaeva, Olga B., Boichuk, Sergei V., Dunaev, Pavel D., Klochkov, Vladimir V., Rakhmatullin, Ilfat Z., Nikitina, Liliya E.

“…[Display omitted] •Novel fluorescent terpene-BODIPY conjugates were synthesized.•The spectral properties, stability and bioactivity of the probes were…”
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Inhibition of FGFR2-Signaling Attenuates a Homology-Mediated DNA Repair in GIST and Sensitizes Them to DNA-Topoisomerase II Inhibitors by Sergei, Boichuk, Pavel, Dunaev, Aigul, Galembikova, Firyuza, Bikinieva, Ilmira, Nurgatina, Ilshat, Mustafin, Aida, Aukhadieva, Refat, Kurtasanov, Natalia, Andriutsa, Elena, Shagimardanova, Vera, Gorbunova

“…Deregulation of receptor tyrosine kinase (RTK)-signaling is frequently observed in many human malignancies, making activated RTKs the promising therapeutic…”
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Infigratinib (BGJ 398), a Pan-FGFR Inhibitor, Targets P-Glycoprotein and Increases Chemotherapeutic-Induced Mortality of Multidrug-Resistant Tumor Cells by Boichuk, Sergei, Dunaev, Pavel, Mustafin, Ilshat, Mani, Shinjit, Syuzov, Kirill, Valeeva, Elena, Bikinieva, Firuza, Galembikova, Aigul

“…The microtubule-targeting agents (MTAs) are well-known chemotherapeutic agents commonly used for therapy of a broad spectrum of human malignancies, exhibiting…”
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Establishment and Characterization of Multi-Drug Resistant p53-Negative Osteosarcoma SaOS-2 Subline by Boichuk, Sergei, Bikinieva, Firyuza, Valeeva, Elena, Dunaev, Pavel, Vasileva, Maria, Kopnin, Pavel, Mikheeva, Ekaterina, Ivoilova, Tatyana, Mustafin, Ilshat, Galembikova, Aigul

“…Aim: To establish a p53-negative osteosarcoma (OS) SaOS-2 cellular subline exhibiting resistance to specific chemotherapeutic agents, including topoisomerase…”
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Developing a Clang-Based Safe Compiler by Dunaev, Pavel Dmitrievich

“…Due to the use of aggressive optimizations by modern C/C++ compilers that exploit undefined behavior, there is a need for a safe compiler that does not perform…”
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Fibroblast Growth Factor 2 (FGF2) Activates Vascular Endothelial Growth Factor (VEGF) Signaling in Gastrointestinal Stromal Tumors (GIST): An Autocrine Mechanism Contributing to Imatinib Mesylate (IM) Resistance by Boichuk, Sergei, Dunaev, Pavel, Galembikova, Aigul, Valeeva, Elena

“…We showed previously that the autocrine activation of the FGFR-mediated pathway in GIST lacking secondary mutations was a result of the inhibition of KIT…”
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Inhibition of fibroblast growth factor receptor-signaling sensitizes imatinib-resistant gastrointestinal stromal tumors to low doses of topoisomerase II inhibitors by Boichuk, Sergei, Dunaev, Pavel, Galembikova, Aigul, Mustafin, Ilshat, Valeeva, Elena

“…The acquired resistance of gastrointestinal stromal tumors (GISTs) to the targeted-based therapy remains the driving force to identify the novel approaches…”
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Establishment and characterization of a triple negative basal-like breast cancer cell line with multi-drug resistance by Boichuk, Sergei, Galembikova, Aigul, Sitenkov, Alexandr, Khusnutdinov, Ramil, Dunaev, Pavel, Valeeva, Elena, Usolova, Natalia

“…Triple-negative breast carcinoma (TNBC) is one of the most aggressive subtypes of breast cancer and is associated with an unfavorable prognosis. The management…”
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Leaf Extract from European Olive (Olea europaea L.) Post-Transcriptionally Suppresses the Epithelial-Mesenchymal Transition and Sensitizes Gastric Cancer Cells to Chemotherapy by Tekin, Cagla, Ercelik, Melis, Dunaev, Pavel, Galembikova, Aigul, Tezcan, Gulcin, Aksoy, Secil Ak, Budak, Ferah, Isık, Ozgen, Ugras, Nesrin, Boichuk, Sergei, Tunca, Berrin

“…The overall survival of patients with the advanced and recurrent gastric cancer (GC) remains unfavorable. In particular, this is due to cancer spreading and…”
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Ethyl-2-amino-pyrrole-3-carboxylates are active against imatinib-resistant gastrointestinal stromal tumors in vitro and in vivo by Boichuk, Sergei, Galembikova, Aigul, Dunaev, Pavel, Micheeva, Ekaterina, Novikova, Maria, Khromova, Natalya, Kopnin, Pavel

“…We showed recently that ethyl-2-amino-pyrrole-3-carboxylates (EAPCs) exhibit potent antiproliferative activities against a broad spectrum of soft tissue…”
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Ethyl-2-amino-pyrrole-3-carboxylates are novel potent anticancer agents that affect tubulin polymerization, induce G2/M cell-cycle arrest, and effectively inhibit soft tissue cancer cell growth in vitro by Boichuk, Sergei, Galembikova, Aigul, Zykova, Svetlana, Ramazanov, Bulat, Khusnutdinov, Ramil, Dunaev, Pavel, Khaibullina, Svetlana, Lombardi, Vincent

“…Microtubules are known to be one of the most attractive and validated targets in cancer therapy. However, the clinical use of drugs that affect the dynamic…”
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Library for Development of Compilers by Mironov, Sergei Vladimirovich, Batraeva, Inna Aleksandrovna, Dunaev, Pavel Dmitrievich

“…This work is devoted to the development of a library designed to implement compilers. The article contains a description of the library's features and the main…”
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Unraveling the Mechanisms of Sensitivity to Anti-FGF Therapies in Imatinib-Resistant Gastrointestinal Stromal Tumors Lacking Secondary IKIT/I Mutations by Boichuk, Sergei, Dunaev, Pavel, Skripova, Vera, Galembikova, Aigul, Bikinieva, Firyuza, Shagimardanova, Elena, Gazizova, Guzel, Deviatiiarov, Ruslan, Valeeva, Elena, Mikheeva, Ekaterina, Vasilyeva, Maria, Kopnin, Pavel, Strelnikov, Vladimir, Kiyamova, Ramziya

“…Acquired resistance of gastrointestinal stromal tumors (GISTs) to imatinib mesylate (IM) is one of the most critical challenges in GIST therapy. Here we show…”
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Unraveling the Mechanisms of Sensitivity to Anti-FGF Therapies in Imatinib-Resistant Gastrointestinal Stromal Tumors (GIST) Lacking Secondary KIT Mutations by Boichuk, Sergei, Dunaev, Pavel, Skripova, Vera, Galembikova, Aigul, Bikinieva, Firyuza, Shagimardanova, Elena, Gazizova, Guzel, Deviatiiarov, Ruslan, Valeeva, Elena, Mikheeva, Ekaterina, Vasilyeva, Maria, Kopnin, Pavel, Strelnikov, Vladimir, Kiyamova, Ramziya

“…We showed previously that inhibition of KIT signaling in GISTs activates FGFR-signaling pathway rendering cancer cells resistant to receptor tyrosine kinase…”
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