Search Results - "Dumuis, A"
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5-HT4 receptors
Published in Current drug targets. CNS & neurological disorders (01-02-2004)“…Serotonin 4 receptors (5-HT(4)Rs) were discovered 15 years ago. They are coded by a very complex gene (700Kb, 38 exons) which generates eight carboxy-terminal…”
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GPCR-interacting proteins (GIPs): nature and functions
Published in Biochemical Society transactions (01-11-2004)“…The simplistic idea that seven transmembrane receptors are single monomeric proteins that interact with heterotrimeric G-proteins after agonist binding is…”
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Modulation of memory processes and cellular excitability in the dentate gyrus of freely moving rats by a 5-HT4 receptors partial agonist, and an antagonist
Published in Neuropharmacology (01-12-2004)“…Firstly, olfactory association learning was used to determine the modulating effect of 5-HT4 receptor involvement in learning and long-term memory. Secondly,…”
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Differential modulation of the 5-HT4 receptor agonists and antagonist on rat learning and memory
Published in Neuropharmacology (01-10-2000)Get full text
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5-HT4 receptors improve social olfactory memory in the rat
Published in Neuropharmacology (01-04-1997)“…Serotonin (5-HT) is involved in a large variety of physiological functions and it appears now that it could play a role in cognitive processes through the…”
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A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system
Published in Molecular pharmacology (01-12-1988)“…A nonclassical 5-hydroxytryptamine (5-HT) receptor mediates the stimulation of adenylate cyclase activity in mouse embryo colliculi neurons in primary culture…”
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Regional distribution and ontogeny of 5-HT4 binding sites in rodent brain
Published in Neuropharmacology (01-03-1994)“…We have investigated the regional distribution of 5-hydroxytryptamine4 (5-HT4) receptor binding sites in the adult guinea pig, rat and mouse brain using the…”
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NMDA receptors activate the arachidonic acid cascade system in striatal neurons
Published in Nature (London) (03-11-1988)“…Receptors for excitatory amino-acid transmitters on nerve cells fall into two main categories associated with non-selective cationic channels, the NMDA…”
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BIMU1 increases associative memory in rats by activating 5-HT4 receptors
Published in Neuropharmacology (01-04-1997)“…Olfactory association learning was used to investigate the involvement of 5-HT4 receptors in learning and long-term memory. The behavioral role of the 5-HT4…”
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5-HT4 Receptors: Cloning and Expression of New Splice Variants
Published in Annals of the New York Academy of Sciences (01-12-1998)“…On the basis of differences in the potencies and intrinsic activity of 5‐HT4 receptor agonists in different biological models it has been suggested that there…”
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Pharmacological characterization of 5-hydroxytryptamine4(5-HT4) receptors positively coupled to adenylate cyclase in adult guinea pig hippocampal membranes: effect of substituted benzamide derivatives
Published in Molecular pharmacology (01-03-1990)“…Adult guinea pig hippocampal membranes contain two 5-hydroxytryptamine (5-HT) receptors positively coupled with an adenylate cyclase. One is a typical 5-HT1A…”
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Lesion study of the distribution of serotonin 5-HT4 receptors in rat basal ganglia and hippocampus
Published in The European journal of neuroscience (01-12-1996)“…The regional distribution of 5-hydroxytryptamine (5-HT4) receptors labelled with [3H]GR113808 was examined in rat basal ganglia and hippocampus after specific…”
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The 5‐HT4 receptor subtype inhibits K+ current in colliculi neurones via activation of a cyclic AMP‐dependent protein kinase
Published in British journal of pharmacology (01-04-1992)“…1 The aim of the present study was to examine the effect of 5‐hydroxytryptamine (5‐HT) on K+ current in primary culture of mouse colliculi neurones and to…”
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cAMP-Dependent, Long-Lasting Inhibition of a K+Current in Mammalian Neurons
Published in Proceedings of the National Academy of Sciences - PNAS (03-07-1995)“…We report the long-term modulation of K+channels by cAMP in cultured murine colliculi neurons. A short (1-2 s) application of 8-Br-cAMP induced a long-lasting…”
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Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture
Published in Molecular pharmacology (01-02-1988)“…Serotonin (5-hydroxytryptamine, 5-HT) inhibited the formation of cAMP promoted by vasoactive intestinal polypeptide, plus forskolin, in mouse hippocampal and…”
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Regional distribution and ontogeny of 5-HT4 binding sites in rat brain
Published in Behavioural brain research (15-12-1995)Get full text
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5-HT4 Receptors: Gene, Transduction and Effects on Olfactory Memory
Published in Annals of the New York Academy of Sciences (15-12-1998)“…In this paper we discuss 1) the primary structures, pharmacology, and brain distribution of cloned 5‐HT4 receptors; 2) the chromosomal localization of the…”
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Serotonin increases calcium current in human atrial myocytes via the newly described 5-hydroxytryptamine4 receptors
Published in Molecular pharmacology (01-02-1992)“…In various species, including humans, 5-hydroxytryptamine (5-HT) has been shown to exert positive chronotropic and inotropic cardiac effects through different…”
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Homologous desensitization of 5-hydroxytryptamine4 receptors in rat esophagus: functional and second messenger studies
Published in The Journal of pharmacology and experimental therapeutics (01-03-1995)“…We have studied agonist-induced desensitization of 5-hydroxytryptamine (5-HT4) receptor-mediated relaxation and 5-HT4 receptor-mediated increases in cAMP in…”
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GPCR interacting proteins (GIP)
Published in Pharmacology & therapeutics (Oxford) (01-09-2004)“…G protein-coupled receptors (GPCR) interact not only with heterotrimeric G proteins but also with accessory proteins called GPCR interacting proteins (GIP)…”
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