Search Results - "Dumrese, Tilman"

Expansion of Protective CD8+ T-Cell Responses Driven by Recombinant Cytomegaloviruses by KARRER, Urs, WAGNER, Markus, SIERRO, Sophie, OXENIUS, Annette, HENGEL, Hartmut, DUMRESE, Tilman, FREIGANG, Stefan, KOSZINOWSKI, Ulrich H, PHILLIPS, Rodney E, KLENERMAN, Paul

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Efficient T Cell Repertoire Selection in Tetraparental Chimeric Mice Independent of Thymic Epithelial MHC by Martinic, Marianne M., Rülicke, Thomas, Althage, Alana, Odermatt, Bernhard, Höchli, Matthias, Lamarre, Alain, Dumrese, Tilman, Speiser, Daniel E., Kyburz, Diego, Hengartner, Hans, Zinkernagel, Rolf M.

“…Nonthymic epithelial cells were compared with thymic epithelial cells for their role in T cell repertoire selection. Tetraparental aggregation chimeras were…”
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Perforin and Fas Act Together in the Induction of Apoptosis, and Both Are Critical in the Clearance of Lymphocytic Choriomeningitis Virus Infection by RODE, Miriam, BALKOW, Sandra, SIMON, Markus M, SOBEK, Vera, BREHM, Reina, MARTIN, Praxedis, KERSTEN, Astrid, DUMRESE, Tilman, STEHLE, Thomas, MÜLLBACHER, Arno, WALLICH, Reinhard

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Identification of Chlamydia pneumoniae-Derived Mouse CD8 Epitopes by SAREN, Anne, PASCOLO, Steve, STEVANOVIC, Stefan, DUMRESE, Tilman, PUOLAKKAINEN, Mirja, SARVAS, Matti, RAMMENSEE, Hans-Georg, VUOLA, Jenni M

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A Naturally Processed Rat Major Histocompatibility Complex Class I-associated Viral Peptide as Target Structure of Borna Disease Virus-specific CD8+ T Cells by Planz, O, Dumrese, T, Hulpusch, S, Schirle, M, Stevanovic, S, Stitz, L

“…The first naturally processed peptide synthesized by a virus and recognized by classical CD8 + T cells in association with the RT1.A l major histocompatibility…”
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Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides by Gallimore, A, Dumrese, T, Hengartner, H, Zinkernagel, R M, Rammensee, H G

“…Infection of C57BL/6 mice with lymphocytic choriomeningitis virus (LCMV) stimulates major histocompatibility complex class I-restricted cytotoxic T cells…”
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Immunodominance of an Antiviral Cytotoxic T Cell Response Is Shaped by the Kinetics of Viral Protein Expression by Probst, Hans Christian, Tschannen, Kathrin, Gallimore, Awen, Martinic, Marianne, Basler, Michael, Dumrese, Tilman, Jones, Emma, van den Broek, Maries F

“…Lymphocytic choriomeningitis virus (LCMV) infection induces a protective CTL response consisting of gp- and nucleoprotein (NP)-specific CTL. We find that a…”
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Virus-Induced Activation of Self-Specific TCRαβ CD8αα Intraepithelial Lymphocytes Does Not Abolish Their Self-Tolerance in the Intestine by Saurer, Leslie, Seibold, Inge, Rihs, Silvia, Vallan, Claudio, Dumrese, Tilman, Mueller, Christoph

“…Abstract TCRαβ CD8αα intestinal intraepithelial lymphocytes (IEL) represent an enigmatic subset of T cells, particularly, in regard to their potential…”
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Critical Role for Activation of Antigen-Presenting Cells in Priming of Cytotoxic T Cell Responses After Vaccination with Virus-Like Particles by Storni, Tazio, Lechner, Franziska, Erdmann, Iris, Bachi, Thomas, Jegerlehner, Andrea, Dumrese, Tilman, Kundig, Thomas M, Ruedl, Christiane, Bachmann, Martin F

“…Virus-like particles (VLPs) are known to induce strong Ab responses in the absence of adjuvants. In addition, VLPs are able to prime CTL responses in vivo. To…”
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Identification of tumor‐associated MHC class I ligands by a novel T cell‐independent approach by Schirle, Markus, Keilholz, Wieland, Weber, Bernd, Gouttefangeas, Cécile, Dumrese, Tilman, Becker, Horst Dieter, Stevanović, Stefan, Rammensee, Hans‐Georg

“…Specific immunotherapy of cancer utilizes tumor‐directed cytotoxic T lymphocytes (CTL) that lyse tumor cells presenting MHC class I‐associated peptides derived…”
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Perforin‐independent regulation of dendritic cell homeostasis by CD8+ T cells in vivo: implications for adaptive immunotherapy by Ludewig, Burkhard, Bonilla, Weldy V., Dumrese, Tilman, Odermatt, Bernhard, Zinkernagel, Rolf M., Hengartner, Hans

“…We investigated here the effects of perforin on CTL responses during interaction of dendritic cells (DC) with cytotoxic T lymphocytes in vivo. Using MHC class…”
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Identification of tumor-associated MHC class I ligands by a novel T cell-independent approach by Schirle, M, Keilholz, W, Weber, B, Gouttefangeas, C, Dumrese, T, Becker, H D, Stevanović, S, Rammensee, H G

“…Specific immunotherapy of cancer utilizes tumor-directed cytotoxic T lymphocytes (CTL) that lyse tumor cells presenting MHC class I-associated peptides derived…”
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Virus-induced activation of self-specific TCR alpha beta CD8 alpha alpha intraepithelial lymphocytes does not abolish their self-tolerance in the intestine by Saurer, Leslie, Seibold, Inge, Rihs, Silvia, Vallan, Claudio, Dumrese, Tilman, Mueller, Christoph

“…TCRalphabeta CD8alphaalpha intestinal intraepithelial lymphocytes (IEL) represent an enigmatic subset of T cells, particularly, in regard to their potential…”
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Antiviral Immune Responses in the Absence of Organized Lymphoid T Cell Zones in plt/plt Mice by Junt, Tobias, Nakano, Hideki, Dumrese, Tilman, Kakiuchi, Terutaka, Odermatt, Bernhard, Zinkernagel, Rolf M, Hengartner, Hans, Ludewig, Burkhard

“…The paucity of lymph node (LN) T cells (plt) mutation in mice results in strongly reduced T cell numbers in LNs and homing defects of both dendritic cells…”
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Lack of Effector Cell Function and Altered Tetramer Binding of Tumor-Infiltrating Lymphocytes by Blohm, Ulrike, Roth, Evelyn, Brommer, Kathrin, Dumrese, Tilman, Rosenthal, Felicia M, Pircher, Hanspeter

“…Tumor-specific CD8 T cell responses to MCA102 fibrosarcoma cells expressing the cytotoxic T cell epitope gp33 from lymphocytic choriomeningitis virus were…”
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A MAGE-A1 HLA-A0201 epitope identified by mass spectrometry by PASCOLO, Steve, SCHIRLE, Markus, GIICKEL, Brigitte, DUMRESE, Tilman, STUMM, Susanne, KAYSER, Simone, MORIS, Arnaud, WALLWIENER, Diethelm, RAMMENSEE, Hans-Georg, STEVANOVIC, Stefan

“…Peptides presented by HLA-A*0201 molecules on the surface of the human breast carcinoma cell line KS24.22 after IFN-gamma induction were analyzed by the…”
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Cutting Edge: Competition for APC by CTLs of Different Specificities Is Not Functionally Important During Induction of Antiviral Responses by Probst, Hans Christian, Dumrese, Tilman, van den Broek, Maries F

“…The hypothesis that T cell competition for access to APC influences priming of CTL responses is a controversial issue. A recent study using OVA as a model Ag…”
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Rapid Peptide Turnover and Inefficient Presentation of Exogenous Antigen Critically Limit the Activation of Self-Reactive CTL by Dendritic Cells by Ludewig, Burkhard, McCoy, Kathy, Pericin, Marcus, Ochsenbein, Adrian F, Dumrese, Tilman, Odermatt, Bernhard, Toes, Rene E. M, Melief, Cornelis J. M, Hengartner, Hans, Zinkernagel, Rolf M

“…This study evaluated to what extent presentation of exogenously acquired self-Ags via MHC class I molecules on DC might contribute to the activation of…”
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Hypercholesterolemia Exacerbates Virus-Induced Immunopathologic Liver Disease Via Suppression of Antiviral Cytotoxic T Cell Responses by Ludewig, Burkhard, Jaggi, Martin, Dumrese, Tilman, Brduscha-Riem, Karin, Odermatt, Bernhard, Hengartner, Hans, Zinkernagel, Rolf M

“…The immune system has to be optimally balanced to be highly effective against infections with cytopathic microbial pathogens and must guarantee efficient…”
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A protective cytotoxic T cell response to a subdominant epitope is influenced by the stability of the MHC class I/peptide complex and the overall spectrum of viral peptides generated within infected cells by Gallimore, Awen, Hombach, Joachim, Dumrese, Tilman, Rammensee, Hans‐Georg, Zinkernagel, Rolf M., Hengartner, Hans

“…This study identifies instability of MHC class I/peptide complexes and intermolecular competition for MHC class I presentation as factors responsible for the…”
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