Search Results - "Dumpit, Ruth F"

A phase I study of niclosamide in combination with enzalutamide in men with castration-resistant prostate cancer by Schweizer, Michael T, Haugk, Kathleen, McKiernan, Jožefa S, Gulati, Roman, Cheng, Heather H, Maes, Jessica L, Dumpit, Ruth F, Nelson, Peter S, Montgomery, Bruce, McCune, Jeannine S, Plymate, Stephen R, Yu, Evan Y

“…Niclosamide, an FDA-approved anti-helminthic drug, has activity in preclinical models of castration-resistant prostate cancer (CRPC). Potential mechanisms of…”
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Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers by Kumar, Akash, White, Thomas A, MacKenzie, Alexandra P, Clegg, Nigel, Lee, Choli, Dumpit, Ruth F, Coleman, Ilsa, Ng, Sarah B, Salipante, Stephen J, Rieder, Mark J, Nickerson, Deborah A, Corey, Eva, Lange, Paul H, Morrissey, Colm, Vessella, Robert L, Nelson, Peter S, Shendure, Jay

“…To catalog protein-altering mutations that may drive the development of prostate cancers and their progression to metastatic disease systematically, we…”
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Correction: A phase I study of niclosamide in combination with enzalutamide in men with castration-resistant prostate cancer by Schweizer, Michael T, Haugk, Kathleen, McKiernan, Jožefa S, Gulati, Roman, Cheng, Heather H, Maes, Jessica L, Dumpit, Ruth F, Nelson, Peter S, Montgomery, Bruce, McCune, Jeannine S, Plymate, Stephen R, Yu, Evan Y

“…[This corrects the article DOI: 10.1371/journal.pone.0198389.]…”
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Genomic attributes of homology-directed DNA repair deficiency in metastatic prostate cancer by De Sarkar, Navonil, Dasgupta, Sayan, Chatterjee, Payel, Coleman, Ilsa, Ha, Gavin, Ang, Lisa S, Kohlbrenner, Emily A, Frank, Sander B, Nunez, Talina A, Salipante, Stephen J, Corey, Eva, Morrissey, Colm, Van Allen, Eliezer, Schweizer, Michael T, Haffner, Michael C, Patel, Radhika, Hanratty, Brian, Lucas, Jared M, Dumpit, Ruth F, Pritchard, Colin C, Montgomery, Robert B, Nelson, Peter S

“…Cancers with homology-directed DNA repair (HRR) deficiency exhibit high response rates to poly(ADP-ribose) polymerase inhibitors (PARPi) and platinum…”
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Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer by Kumar, Akash, Coleman, Ilsa, Morrissey, Colm, Zhang, Xiaotun, True, Lawrence D, Gulati, Roman, Etzioni, Ruth, Bolouri, Hamid, Montgomery, Bruce, White, Thomas, Lucas, Jared M, Brown, Lisha G, Dumpit, Ruth F, DeSarkar, Navonil, Higano, Celestia, Yu, Evan Y, Coleman, Roger, Schultz, Nikolaus, Fang, Min, Lange, Paul H, Shendure, Jay, Vessella, Robert L, Nelson, Peter S

“…Genomic analysis of a single metastasis informs about the oncogenic—and potentially druggable—genomic alterations present in other tumors within the same man…”
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Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling by Bluemn, Eric G., Coleman, Ilsa M., Lucas, Jared M., Coleman, Roger T., Hernandez-Lopez, Susana, Tharakan, Robin, Bianchi-Frias, Daniella, Dumpit, Ruth F., Kaipainen, Arja, Corella, Alexandra N., Yang, Yu Chi, Nyquist, Michael D., Mostaghel, Elahe, Hsieh, Andrew C., Zhang, Xiaotun, Corey, Eva, Brown, Lisha G., Nguyen, Holly M., Pienta, Kenneth, Ittmann, Michael, Schweizer, Michael, True, Lawrence D., Wise, David, Rennie, Paul S., Vessella, Robert L., Morrissey, Colm, Nelson, Peter S.

“…Androgen receptor (AR) signaling is a distinctive feature of prostate carcinoma (PC) and represents the major therapeutic target for treating metastatic…”
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Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells by Crist, Sarah B., Nemkov, Travis, Dumpit, Ruth F., Dai, Jinxiang, Tapscott, Stephen J., True, Lawrence D., Swarbrick, Alexander, Sullivan, Lucas B., Nelson, Peter S., Hansen, Kirk C., Ghajar, Cyrus M.

“…Skeletal muscle has long been recognized as an inhospitable site for disseminated tumour cells (DTCs). Yet its antimetastatic nature has eluded a thorough…”
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Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program and repress cancer growth by Nyquist, Michael D, Ang, Lisa S, Corella, Alexandra, Coleman, Ilsa M, Meers, Michael P, Christiani, Anthony J, Pierce, Cordell, Janssens, Derek H, Meade, Hannah E, Bose, Arnab, Brady, Lauren, Howard, Timothy, De Sarkar, Navonil, Frank, Sander B, Dumpit, Ruth F, Dalton, James T, Corey, Eva, Plymate, Stephen R, Haffner, Michael C, Mostaghel, Elahe A, Nelson, Peter S

“…Prostate cancer (PC) is driven by androgen receptor (AR) activity, a master regulator of prostate development and homeostasis. Frontline therapies for…”
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Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes by De Sarkar, Navonil, Patton, Robert D, Doebley, Anna-Lisa, Hanratty, Brian, Adil, Mohamed, Kreitzman, Adam J, Sarthy, Jay F, Ko, Minjeong, Brahma, Sandipan, Meers, Michael P, Janssens, Derek H, Ang, Lisa S, Coleman, Ilsa M, Bose, Arnab, Dumpit, Ruth F, Lucas, Jared M, Nunez, Talina A, Nguyen, Holly M, McClure, Heather M, Pritchard, Colin C, Schweizer, Michael T, Morrissey, Colm, Choudhury, Atish D, Baca, Sylvan C, Berchuck, Jacob E, Freedman, Matthew L, Ahmad, Kami, Haffner, Michael C, Montgomery, R Bruce, Corey, Eva, Henikoff, Steven, Nelson, Peter S, Ha, Gavin

“…Advanced prostate cancers comprise distinct phenotypes, but tumor classification remains clinically challenging. Here, we harnessed circulating tumor DNA…”
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Publisher Correction: Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells by Crist, Sarah B., Nemkov, Travis, Dumpit, Ruth F., Dai, Jinxiang, Tapscott, Stephen J., True, Lawrence D., Swarbrick, Alexander, Sullivan, Lucas B., Nelson, Peter S., Hansen, Kirk C., Ghajar, Cyrus M.

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Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program and repress cancer growth by Nyquist, Michael D, Ang, Lisa S, Corella, Alexandra, Coleman, Ilsa M, Meers, Michael P, Christiani, Anthony J, Pierce, Cordell, Janssens, Derek H, Meade, Hannah E, Bose, Arnab, Brady, Lauren, Howard, Timothy, De Sarkar, Navonil, Frank, Sander B, Dumpit, Ruth F, Dalton, James T, Corey, Eva, Plymate, Stephen R, Haffner, Michael C, Mostaghel, Elahe A, Nelson, Peter S

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Concurrent Targeting of HDAC and PI3K to Overcome Phenotypic Heterogeneity of Castration-resistant and Neuroendocrine Prostate Cancers by Zhang, Ailin, Lau, Nathan A, Wong, Alicia, Brown, Lisha G, Coleman, Ilsa M, De Sarkar, Navonil, Li, Dapei, DeLucia, Diana C, Labrecque, Mark P, Nguyen, Holly M, Conner, Jennifer L, Dumpit, Ruth F, True, Lawrence D, Lin, Daniel W, Corey, Eva, Alumkal, Joshi J, Nelson, Peter S, Morrissey, Colm, Lee, John K

“…Castration-resistant prostate cancer (CRPC) consists of multiple phenotypic subtypes including androgen receptor (AR)-active prostate cancer (ARPC) and…”
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Differential Gene Expression in Benign Prostate Epithelium of Men with and without Prostate Cancer: Evidence for a Prostate Cancer Field Effect by RISK, Michael C, KNUDSEN, Beatrice S, COLEMAN, Ilsa, DUMPIT, Ruth F, KRISTAL, Alan R, LEMEUR, Nolwenn, GENTLEMAN, Robert C, TRUE, Lawrence D, NELSON, Peter S, LIN, Daniel W

“…Several malignancies are known to exhibit a "field effect," whereby regions beyond tumor boundaries harbor histologic or molecular changes that are associated…”
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Challenges in enrolling to metastatic castration-resistant prostate cancer (mCRPC) studies that require androgen receptor splice variant (AR-V) positivity by Schweizer, Michael Thomas, Haugk, Kathleen, Cheng, Heather H., Maes, Jessica L, Dumpit, Ruth F, Nelson, Peter, Montgomery, Robert B., Plymate, Stephen R, Yu, Evan Y.

“…Abstract only 264 Background: AR-Vs are truncated androgen receptor (AR) isoforms that lack the ligand-binding domain (LBD) and are associated with resistance…”
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Abstract IA21: AR is ablated: Now what? Targeting the double-negative phenotype by Morrissey, Colm, Bluemn, Eric G., Coleman, Ilsa M., Lucas, Jared M., Coleman, Roger T., Tharakan, Robin, Bianchi-Frias, Daniella, Dumpit, Ruth F., Kaipainen, Arja, Corella, Alexandra N., Yang, Yu Chi, Nyquist, Michael D., Mostaghel, Elahe, Zhang, Xiaotun, Corey, Eva, Brown, Lisha G., Nguyen, Holly M., Schweizer, Michael, True, Lawrence D., Rennie, Paul S., Vessella, Robert L., Nelson, Peter S.

“…Abstract Background/Introduction: Androgen receptor (AR) signaling is a distinctive feature of prostate cancer (PC) and represents the major therapeutic target…”
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Substantial inter-individual and limited intra-individual genomic diversity among tumors from men with metastatic prostate cancer by Kumar, Akash, Coleman, Ilsa, Morrissey, Colm, Zhang, Xiaotun, True, Lawrence D., Gulati, Roman, Etzioni, Ruth, Bolouri, Hamid, Montgomery, Bruce, White, Thomas, Lucas, Jared M., Brown, Lisha G., Dumpit, Ruth F., DeSarkar, Navonil, Higano, Celestia, Yu, Evan Y., Coleman, Roger, Schultz, Nikolaus, Fang, Min, Lange, Paul H., Shendure, Jay, Vessella, Robert L., Nelson, Peter S.

“…Intra-individual tumor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for cancers that have metastasized. To determine whether…”
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Abstract 5059: Exome and targeted sequencing to discover and validate candidate genes in advanced and lethal prostate cancer by Kumar, Akash, MacKenzie, Alexandra P., O'Roak, Brian J., Coleman, Ilsa, Morrissey, Colm, Lee, Choli, White, Thomas A., Dumpit, Ruth F., True, Lawrence D., Corey, Eva, Vessella, Robert L., Nelson, Peter S., Shendure, Jay

“…Abstract Prostate carcinoma is the most common malignancy and the second leading cause of cancer mortality in men. In order to understand the genetic…”
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