Search Results - "Dumont, Nicolas"

Intrinsic and extrinsic mechanisms regulating satellite cell function by Dumont, Nicolas A, Wang, Yu Xin, Rudnicki, Michael A

“…Muscle stem cells, termed satellite cells, are crucial for skeletal muscle growth and regeneration. In healthy adult muscle, satellite cells are quiescent but…”
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Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases by Molina, Thomas, Fabre, Paul, Dumont, Nicolas A

“…Skeletal muscle possesses a remarkable regenerative capacity that relies on the activity of muscle stem cells, also known as satellite cells. The presence of…”
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Cellular dynamics in the muscle satellite cell niche by Bentzinger, C Florian, Wang, Yu Xin, Dumont, Nicolas A, Rudnicki, Michael A

“…Satellite cells, the quintessential skeletal muscle stem cells, reside in a specialized local environment whose anatomy changes dynamically during tissue…”
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Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division by Dumont, Nicolas A, Wang, Yu Xin, von Maltzahn, Julia, Pasut, Alessandra, Bentzinger, C Florian, Brun, Caroline E, Rudnicki, Michael A

“…Dystrophin is expressed in muscle stem cells, in which it regulates their cell division and proper repopulation. Dystrophin is expressed in differentiated…”
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Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases by Dumont, Nicolas A., Molina, Thomas, Fabre, Paul, Dort, Junio

“…Muscle regeneration is a closely regulated process that involves a variety of cell types such as satellite cells, myofibers, fibroadipogenic progenitors,…”
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Inhibition of JAK-STAT signaling stimulates adult satellite cell function by Price, Feodor D, von Maltzahn, Julia, Bentzinger, C Florian, Dumont, Nicolas A, Yin, Hang, Chang, Natasha C, Wilson, David H, Frenette, Jérôme, Rudnicki, Michael A

“…In two new reports, STAT3 signaling is shown to be increased in adult muscle satellite cells, and its inhibition improves muscle regeneration. Diminished…”
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EGFR-Aurka Signaling Rescues Polarity and Regeneration Defects in Dystrophin-Deficient Muscle Stem Cells by Increasing Asymmetric Divisions by Wang, Yu Xin, Feige, Peter, Brun, Caroline E., Hekmatnejad, Bahareh, Dumont, Nicolas A., Renaud, Jean-Marc, Faulkes, Sharlene, Guindon, Daniel E., Rudnicki, Michael A.

“…Loss of dystrophin expression in Duchenne muscular dystrophy (DMD) causes progressive degeneration of skeletal muscle, which is exacerbated by reduced…”
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Muscle stem cells at a glance by Wang, Yu Xin, Dumont, Nicolas A, Rudnicki, Michael A

“…Muscle stem cells facilitate the long-term regenerative capacity of skeletal muscle. This self-renewing population of satellite cells has only recently been…”
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Transient neonatal exposure to hyperoxia, an experimental model of preterm birth, leads to skeletal muscle atrophy and fiber type switching by Deprez, Alyson, Orfi, Zakaria, Radu, Alexandra, He, Ying, Ravizzoni Dartora, Daniela, Dort, Junio, Dumont, Nicolas A, Nuyt, Anne Monique

“…Individuals born preterm show reduced exercise capacity and increased risk for pulmonary and cardiovascular diseases, but the impact of preterm birth on…”
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Resolvin-D2 targets myogenic cells and improves muscle regeneration in Duchenne muscular dystrophy by Dort, Junio, Orfi, Zakaria, Fabre, Paul, Molina, Thomas, Conte, Talita C., Greffard, Karine, Pellerito, Ornella, Bilodeau, Jean-François, Dumont, Nicolas A.

“…Lack of dystrophin causes muscle degeneration, which is exacerbated by chronic inflammation and reduced regenerative capacity of muscle stem cells in Duchenne…”
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Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice by Lukjanenko, Laura, Jung, M Juliane, Hegde, Nagabhooshan, Perruisseau-Carrier, Claire, Migliavacca, Eugenia, Rozo, Michelle, Karaz, Sonia, Jacot, Guillaume, Schmidt, Manuel, Li, Liangji, Metairon, Sylviane, Raymond, Frederic, Lee, Umji, Sizzano, Federico, Wilson, David H, Dumont, Nicolas A, Palini, Alessio, Fässler, Reinhard, Steiner, Pascal, Descombes, Patrick, Rudnicki, Michael A, Fan, Chen-Ming, von Maltzahn, Julia, Feige, Jerome N, Bentzinger, C Florian

“…During aging, the levels of fibronectin in the muscle stem cell niche decline, contributing to age-related frailty, and supplementation restores youth-like…”
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Characterizing Satellite Cells and Myogenic Progenitors During Skeletal Muscle Regeneration by Dumont, Nicolas A, Rudnicki, Michael A

“…Muscle stem cells, named satellite cells, are quiescent in resting skeletal muscle. Following injury, satellite cells are activated and become proliferating…”
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Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies by Deprez, Alyson, Orfi, Zakaria, Rieger, Lupann, Dumont, Nicolas Alexandre

“…Skeletal muscle possesses a high plasticity and a remarkable regenerative capacity that relies mainly on muscle stem cells (MuSCs). Molecular and cellular…”
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Clearance of defective muscle stem cells by senolytics restores myogenesis in myotonic dystrophy type 1 by Conte, Talita C., Duran-Bishop, Gilberto, Orfi, Zakaria, Mokhtari, Inès, Deprez, Alyson, Côté, Isabelle, Molina, Thomas, Kim, Tae-Yeon, Tellier, Lydia, Roussel, Marie-Pier, Maggiorani, Damien, Benabdallah, Basma, Leclerc, Severine, Feulner, Lara, Pellerito, Ornella, Mathieu, Jean, Andelfinger, Gregor, Gagnon, Cynthia, Beauséjour, Christian, McGraw, Serge, Duchesne, Elise, Dumont, Nicolas A.

“…Muscle stem cells, the engine of muscle repair, are affected in myotonic dystrophy type 1 (DM1); however, the underlying molecular mechanism and the impact on…”
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Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength by Bentzinger, C Florian, von Maltzahn, Julia, Dumont, Nicolas A, Stark, Danny A, Wang, Yu Xin, Nhan, Kevin, Frenette, Jérôme, Cornelison, D D W, Rudnicki, Michael A

“…Wnt7a/Fzd7 signaling stimulates skeletal muscle growth and repair by inducing the symmetric expansion of satellite stem cells through the planar cell polarity…”
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Decreased dystrophin expression and elevated dystrophin-targeting miRNAs in anti-HMGCR immune-mediated necrotizing myopathy by Marmen, Maude B., Orfi, Zakaria, Dort, Junio, Proulx-Gauthier, Jean-Philippe, Chrestian, Nicolas, Dumont, Nicolas A., Ellezam, Benjamin

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Adults born preterm have lower peripheral skeletal muscle area and strength by Deprez, Alyson, El-Jalbout, Ramy, Cloutier, Anik, Gagnon, Dany H., Gagnon Hamelin, Andréa, Mathieu, Marie-Eve, Kugathasan, Thiffya Arabi, Dumont, Nicolas A., Nuyt, Anne Monique, Luu, Thuy Mai

“…Prematurity is associated with lower exercise capacity, which relies on the integrity of the cardiovascular, pulmonary, and skeletal muscle systems. Our animal…”
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Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells by Dick, Sarah A., Chang, Natasha C., Dumont, Nicolas A., Bell, Ryan A. V., Putinski, Charis, Kawabe, Yoichi, Litchfield, David W., Rudnicki, Michael A., Megeney, Lynn A.

“…Compensatory growth and regeneration of skeletal muscle is dependent on the resident stem cell population, satellite cells (SCs). Self-renewal and maintenance…”
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Macrophage Colony-Stimulating Factor–Induced Macrophage Differentiation Promotes Regrowth in Atrophied Skeletal Muscles and C2C12 Myotubes by Dumont, Nicolas A, Frenette, Jérôme

“…Skeletal muscle injury and regeneration are closely associated with an inflammatory reaction that is usually characterized by sequential recruitment of…”
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The adhesion G-protein-coupled receptor Gpr116 is essential to maintain the skeletal muscle stem cell pool by Sénéchal, Charlotte, Fujita, Ryo, Jamet, Solène, Maiga, Arhamatoulaye, Dort, Junio, Orfi, Zakaria, Dumont, Nicolas A., Bouvier, Michel, Crist, Colin

“…Skeletal muscle is populated with a reservoir of quiescent muscle stem cells (MuSCs), which regenerate the tissue after injury. Here, we show that the adhesion…”
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