Search Results - "Dumont, Ashley"

Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular by Melehani, Jason H, James, David B A, DuMont, Ashley L, Torres, Victor J, Duncan, Joseph A

“…Staphylococcus aureus infections are a growing health burden worldwide, and paramount to this bacterium's pathogenesis is the production of virulence factors,…”
Get full text

Cell targeting by the Staphylococcus aureus pore-forming toxins: it's not just about lipids by DuMont, Ashley L, Torres, Victor J

“…Highlights • Staphylococcus aureus pore-forming toxins (PFTs) use different proteinaceous receptors to target host cells. • Receptors explain cell-type and…”
Get full text

Stenotrophomonas maltophilia Serine Protease StmPr1 Induces Matrilysis, Anoikis, and Protease-Activated Receptor 2 Activation in Human Lung Epithelial Cells by DuMont, Ashley L, Cianciotto, Nicholas P

“…is an emerging, opportunistic nosocomial pathogen that can cause severe disease in immunocompromised individuals. We recently identified the StmPr1 and StmPr2…”
Get full text

CCR5 is a receptor for Staphylococcus aureus leukotoxin ED by Alonzo III, Francis, Kozhaya, Lina, Rawlings, Stephen A., Reyes-Robles, Tamara, DuMont, Ashley L., Myszka, David G., Landau, Nathaniel R., Unutmaz, Derya, Torres, Victor J.

“…Pore-forming toxins are critical virulence factors for many bacterial pathogens and are central to Staphylococcus aureus- mediated killing of host cells. S…”
Get full text

Staphylococcus aureus LukAB cytotoxin kills human neutrophils by targeting the CD11b subunit of the integrin Mac-1 by DuMont, Ashley L., Yoong, Pauline, Day, Christopher J., Alonzo, Francis, McDonald, W. Hayes, Jennings, Michael P., Torres, Victor J.

“…Staphylococcus aureus causes diseases ranging from superficial wound infections to more invasive manifestations like osteomyelitis and endocarditis. The…”
Get full text

Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection by Nygaard, Tyler K, Pallister, Kyler B, DuMont, Ashley L, DeWald, Mark, Watkins, Robert L, Pallister, Erik Q, Malone, Cheryl, Griffith, Shannon, Horswill, Alexander R, Torres, Victor J, Voyich, Jovanka M

“…This investigation examines the influence of alpha-toxin (Hla) during USA300 infection of human leukocytes. Survival of an USA300 isogenic deletion mutant of…”
Get full text

Stenotrophomonas maltophilia Encodes a VirB/VirD4 Type IV Secretion System That Modulates Apoptosis in Human Cells and Promotes Competition against Heterologous Bacteria, Including Pseudomonas aeruginosa by Nas, Megan Y, White, Richard C, DuMont, Ashley L, Lopez, Alberto E, Cianciotto, Nicholas P

“…is an emerging opportunistic and nosocomial pathogen. is also a risk factor for lung exacerbations in cystic fibrosis patients. attaches to various mammalian…”
Get full text

Exome sequencing in schizophrenia-affected parent–offspring trios reveals risk conferred by protein-coding de novo mutations by Howrigan, Daniel P., Rose, Samuel A., Samocha, Kaitlin E., Fromer, Menachem, Cerrato, Felecia, Chen, Wei J., Churchhouse, Claire, Chambert, Kimberly, Chandler, Sharon D., Daly, Mark J., Dumont, Ashley, Genovese, Giulio, Hwu, Hai-Gwo, Laird, Nan, Kosmicki, Jack A., Moran, Jennifer L., Roe, Cheryl, Singh, Tarjinder, Wang, Shi-Heng, Faraone, Stephen V., Glatt, Stephen J., McCarroll, Steven A., Tsuang, Ming, Neale, Benjamin M.

“…Protein-coding de novo mutations (DNMs) are significant risk factors in many neurodevelopmental disorders, whereas schizophrenia (SCZ) risk associated with…”
Get full text

Staphylococcus aureus Elaborates Leukocidin AB To Mediate Escape from within Human Neutrophils by DuMont, Ashley L, Yoong, Pauline, Surewaard, Bas G J, Benson, Meredith A, Nijland, Reindert, van Strijp, Jos A G, Torres, Victor J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Type II Secretion-Dependent Degradative and Cytotoxic Activities Mediated by Stenotrophomonas maltophilia Serine Proteases StmPr1 and StmPr2 by DuMont, Ashley L, Karaba, Sara M, Cianciotto, Nicholas P

“…Stenotrophomonas maltophilia is an emerging opportunistic pathogen that primarily causes pneumonia and bacteremia in immunocompromised individuals. We recently…”
Get full text

Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin by Spaan, András N, Neehus, Anna-Lena, Laplantine, Emmanuel, Staels, Frederik, Ogishi, Masato, Seeleuthner, Yoann, Rapaport, Franck, Lacey, Keenan A, Van Nieuwenhove, Erika, Chrabieh, Maya, Hum, David, Migaud, Mélanie, Izmiryan, Araksya, Lorenzo, Lazaro, Kochetkov, Tatiana, Heesterbeek, Dani A C, Bardoel, Bart W, DuMont, Ashley L, Dobbs, Kerry, Chardonnet, Solenne, Heissel, Søren, Baslan, Timour, Zhang, Peng, Yang, Rui, Bogunovic, Dusan, Wunderink, Herman F, Haas, Pieter-Jan A, Molina, Henrik, Van Buggenhout, Griet, Lyonnet, Stanislas, Notarangelo, Luigi D, Seppänen, Mikko R J, Weil, Robert, Seminario, Gisela, Gomez-Tello, Héctor, Wouters, Carine, Mesdaghi, Mehrnaz, Shahrooei, Mohammad, Bossuyt, Xavier, Sag, Erdal, Topaloglu, Rezan, Ozen, Seza, Leavis, Helen L, van Eijk, Maarten M J, Bezrodnik, Liliana, Blancas Galicia, Lizbeth, Hovnanian, Alain, Nassif, Aude, Bader-Meunier, Brigitte, Neven, Bénédicte, Meyts, Isabelle, Schrijvers, Rik, Puel, Anne, Bustamante, Jacinta, Aksentijevich, Ivona, Kastner, Daniel L, Torres, Victor J, Humblet-Baron, Stéphanie, Liston, Adrian, Abel, Laurent, Boisson, Bertrand, Casanova, Jean-Laurent

“…The molecular basis of interindividual clinical variability upon infection with is unclear. We describe patients with haploinsufficiency for the linear…”
Get full text

Vaccination With Detoxified Leukocidin AB Reduces Bacterial Load in a Staphylococcus aureus Minipig Deep Surgical Wound Infection Model by Fernandez, Jeffrey, Sanders, Holly, Henn, Jessica, Wilson, Jolaine M, Malone, Danielle, Buoninfante, Alessandra, Willms, Matthew, Chan, Rita, DuMont, Ashley L, McLahan, Craig, Grubb, Kaitlyn, Romanello, Anthony, van den Dobbelsteen, Germie, Torres, Victor J, Poolman, Jan T

“…Abstract Vaccines against Staphylococcus aureus have eluded researchers for >3 decades while the burden of staphylococcal diseases has increased. Early vaccine…”
Get full text

Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections by Buckley, Peter T., Chan, Rita, Fernandez, Jeffrey, Luo, Jinquan, Lacey, Keenan A., DuMont, Ashley L., O’Malley, Aidan, Brezski, Randall J., Zheng, Songmao, Malia, Thomas, Whitaker, Brian, Zwolak, Adam, Payne, Angela, Clark, Desmond, Sigg, Martin, Lacy, Eilyn R., Kornilova, Anna, Kwok, Debra, McCarthy, Steve, Wu, Bingyuan, Morrow, Brian, Nemeth-Seay, Jennifer, Petley, Ted, Wu, Sam, Strohl, William R., Lynch, Anthony Simon, Torres, Victor J.

“…Treating and preventing infections by antimicrobial-resistant bacterial pathogens is a worldwide problem. Pathogens such as Staphylococcus aureus produce an…”
Get full text

Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis by DuMont, Ashley L, Nygaard, Tyler K, Watkins, Robert L, Smith, Amanda, Kozhaya, Lina, Kreiswirth, Barry N, Shopsin, Bo, Unutmaz, Derya, Voyich, Jovanka M, Torres, Victor J

“…Staphylococcus aureus is an important pathogen that continues to be a significant global health threat because of the prevalence of methicillin-resistant S…”
Get full text

Capsular Polysaccharide Is Essential for the Virulence of the Antimicrobial-Resistant Pathogen Enterobacter hormaechei by St John, Amelia, Perault, Andrew I, Giacometti, Sabrina I, Sommerfield, Alexis G, DuMont, Ashley L, Lacey, Keenan A, Zheng, Xuhui, Sproch, Julia, Petzold, Chris, Dancel-Manning, Kristen, Gonzalez, Sandra, Annavajhala, Medini, Beckford, Colleen, Zeitouni, Nathalie, Liang, Feng-Xia, van Bakel, Harm, Shopsin, Bo, Uhlemann, Anne-Catrin, Pironti, Alejandro, Torres, Victor J

“…Nosocomial infections caused by multidrug-resistant (MDR) Enterobacter cloacae complex (ECC) pathogens are on the rise. However, the virulence strategies…”
Get full text

SARS-CoV-2 infection predisposes patients to coinfection with Staphylococcus aureus by Lubkin, Ashira, Bernard-Raichon, Lucie, DuMont, Ashley L, Valero Jimenez, Ana Mayela, Putzel, Gregory G, Gago, Juan, Zwack, Erin E, Olusanya, Olufolakemi, Boguslawski, Kristina M, Dallari, Simone, Dyzenhaus, Sophie, Herrmann, Christin, Ilmain, Juliana K, Isom, Georgia L, Pawline, Miranda, Perault, Andrew I, Perelman, Sofya, Sause, William E, Shahi, Ifrah, St John, Amelia, Tierce, Rebecca, Zheng, Xuhui, Zhou, Chunyi, Noval, Maria G, O'Keeffe, Anna, Podkowik, Magda, Gonzales, Sandra, Inglima, Kenneth, Desvignes, Ludovic, Hochman, Sarah E, Stapleford, Kenneth A, Thorpe, Lorna E, Pironti, Alejandro, Shopsin, Bo, Cadwell, Ken, Dittmann, Meike, Torres, Victor J

“…Severe COVID-19 has been associated with coinfections with bacterial and fungal pathogens. Notably, patients with COVID-19 who develop bacteremia exhibit…”
Get full text

Children with Invasive Staphylococcus aureus Disease Exhibit a Potently Neutralizing Antibody Response to the Cytotoxin LukAB by Thomsen, Isaac P, Dumont, Ashley L, James, David B A, Yoong, Pauline, Saville, Benjamin R, Soper, Nicole, Torres, Victor J, Creech, C Buddy

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress by Podkowik, Magdalena, Perault, Andrew I, Putzel, Gregory, Pountain, Andrew, Kim, Jisun, DuMont, Ashley L, Zwack, Erin E, Ulrich, Robert J, Karagounis, Theodora K, Zhou, Chunyi, Haag, Andreas F, Shenderovich, Julia, Wasserman, Gregory A, Kwon, Junbeom, Chen, John, Richardson, Anthony R, Weiser, Jeffrey N, Nowosad, Carla R, Lun, Desmond S, Parker, Dane, Pironti, Alejandro, Zhao, Xilin, Drlica, Karl, Yanai, Itai, Torres, Victor J, Shopsin, Bo

“…The quorum-sensing system links metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H O , a crucial…”
Get full text

Staphylococcus aureus Peptide Methionine Sulfoxide Reductases Protect from Human Whole-Blood Killing by Beavers, William N, DuMont, Ashley L, Monteith, Andrew J, Maloney, K Nichole, Tallman, Keri A, Weiss, Andy, Christian, Alec H, Toste, F Dean, Chang, Christopher J, Porter, Ned A, Torres, Victor J, Skaar, Eric P

“…The generation of oxidative stress is a host strategy used to control Staphylococcus aureus infections. Sulfur-containing amino acids, cysteine and methionine,…”
Get full text

Identification of a Crucial Residue Required for Staphylococcus aureus LukAB Cytotoxicity and Receptor Recognition by DuMont, Ashley L, Yoong, Pauline, Liu, Xiang, Day, Christopher J, Chumbler, Nicole M, James, David B A, Alonzo, 3rd, Francis, Bode, Nadine J, Lacy, D Borden, Jennings, Michael P, Torres, Victor J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text