Search Results - "Dumond, Julie B"

The effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study by Chen, Jingxian, Titanji, Kehmia, Sheth, Anandi N, Gandhi, Rajesh, McMahon, Deborah, Ofotokun, Ighovwerha, Weitzmann, M Neale, De Paris, Kristina, Dumond, Julie B

“…Older age could be a risk factor for suboptimal CD4+ T-cell recovery in HIV-infected patients despite successful viral suppression. However, evaluation of this…”
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A multicompartment population PK model to predict tenofovir and emtricitabine mucosal tissue concentrations for HIV prevention by Leung, Erick, Cottrell, Mackenzie L., Sykes, Craig, White, Nicole, Kashuba, Angela D. M., Dumond, Julie B.

“…A priori use of mathematical modeling and simulation to predict outcomes from incomplete adherence or reduced frequency dosing strategies may mitigate the risk…”
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Maraviroc Concentrates in the Cervicovaginal Fluid and Vaginal Tissue of HIV-Negative Women by DUMOND, Julie B, PATTERSON, Kristine B, PECHA, Allison L, WERNER, Rebecca E, ANDREWS, Emma, DAMLE, Bharat, TRESSLER, Randall, WORSLEY, Jochen, KASHUBA, Angela D. M

“…To compare single- and multiple-dose maraviroc exposures in cervicovaginal fluid (CVF) and vaginal tissue (VT) with blood plasma (BP) and quantify maraviroc…”
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Pharmacokinetic Modeling to Guide Preclinical Development of an Islatravir-Eluting Reservoir-Style Biodegradable Implant for Long-Acting HIV PrEP by Kinsale, Talisa S, Cottrell, Mackenzie L, Li, Linying, Brand, Rhonda, Gatto, Greg, Luecke, Ellen, Norton, Chasity, Krovi, Archana, Dumond, Julie B, Rao, Gauri, Yeshwante, Shekhar, Van Horne, Brian, Van Der Straten, Ariane, Kashuba, Angela D M, Johnson, Leah M

“…Long-acting injectable cabotegravir is more effective than daily oral PrEP at preventing HIV transmission due to improved adherence, but requires bi-monthly…”
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Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16INK4a or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection by Maas, Brian M, Francis, Owen, Mollan, Katie R, Lee, Cynthia, Cottrell, Mackenzie L, Prince, Heather M A, Sykes, Craig, Trezza, Christine, Torrice, Chad, White, Nicole, Malone, Stephanie, Hudgens, Michael G, Sharpless, Norman E, Dumond, Julie B

“…As the HIV-infected population ages, the role of cellular senescence and inflammation on co-morbid conditions and pharmacotherapy is increasingly of interest…”
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Shifting the Narrative of Preexposure Prophylaxis Adherence Counseling for Cisgender Women by Sheth, Anandi N, Momplaisir, Florence, Dumond, Julie B

“…Despite the approval of emtricitabine and tenofovir disoproxil fumarate (FTDF) for HIV preexposure prophylaxis (PrEP), new HIV infections among cisgender women…”
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Genital Tract, Cord Blood, and Amniotic Fluid Exposures of Seven Antiretroviral Drugs during and after Pregnancy in Human Immunodeficiency Virus Type 1-Infected Women by YEH, Rosa F, REZK, Naser L, PATTERSON, Kristine B, KASHUBA, Angela D. M, DUMOND, Julie B, TAPPOUNI, Hiba L, TIEN, Hsiao-Chuan, CHEN, Ya-Chi, VOURVAHIS, Manoli, HORTON, Amanda L, FISCUS, Susan A

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Modest but Variable Effect of Rifampin on Steady-State Plasma Pharmacokinetics of Efavirenz in Healthy African-American and Caucasian Volunteers by KWARA, Awewura, TASHIMA, Karen T, DUMOND, Julie B, POETHKE, Pamela, KURPEWSKI, Jaclyn, KASHUBA, Angela D. M, COURT, Michael H, GREENBLATT, David J

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Raltegravir Pharmacokinetics in Treatment-Naive Patients Is Not Influenced by Race: Results from the Raltegravir Early Therapy in African-Americans Living with HIV (REAL) Study by WOHL, David A, DUMOND, Julie B, RICHARDSON, Amy, HUDGENS, Michael G, KASHUBA, Angela D. M, BLEVINS, Suzanne, PITTARD, Donna, RAGAN, David, RUILI WANG, MASSENGALE, Kelley, WALSH, Kendall, FLORIS-MOORE, Michelle, ERON, Joseph J

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Lenacapavir: Playing the Long Game in the New Era of Antiretrovirals by Neverette, Noah C, Dumond, Julie B, McMahon, Deborah K, Devanathan, Aaron S

“…The mainstay of antiretroviral therapy (ART) has been combination oral therapy. While oral ART is highly effective, nonadherence remains a chief concern…”
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Déjà vu all over again by Saag, Michael S, Dumond, Julie B

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Impact of Pregnancy on the Pharmacokinetics and Metabolism of Nicotinamide in Humans by Fashe, Muluneh M., Le, Tien V., Gower, Megan N., Mulrenin, Ian R., Dorman, Karen F., Smith, Spenser, Fallon, John K., Dumond, Julie B., Boggess, Kim A., Lee, Craig R.

“…In pre‐eclampsia models, nicotinamide (NAM) has protective effects in pre‐eclampsia and is being evaluated as a therapeutic nutraceutical in clinical studies…”
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Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration by Byrnes, James R, Lee, Taek, Sharaby, Sherif, Campbell, Robert A, Dobson, Dre'Von A, Holle, Lori A, Luo, Michelle, Kangro, Kadri, Homeister, Jonathon W, Aleman, Maria M, Luyendyk, James P, Kerlin, Bryce A, Dumond, Julie B, Wolberg, Alisa S

“…Transglutaminase factor XIII (FXIII) is essential for hemostasis, wound healing, and pregnancy maintenance. Plasma FXIII is composed of A and B subunit dimers…”
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A Novel Algorithm to Improve PrEP Adherence Monitoring Using Dried Blood Spots by Devanathan, Aaron S., Dumond, Julie B., Anderson, Daijha J.C., Moody, Kristen, Poliseno, Amanda J., Schauer, Amanda P., Sykes, Craig, Gay, Cynthia L., Rosen, Elias P., Kashuba, Angela D.M., Cottrell, Mackenzie L.

“…Tenofovir diphosphate (TFVdp; an active metabolite of oral HIV pre‐exposure prophylaxis (PrEP)) is measured in dried blood spots (DBS) to estimate adherence…”
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Short and Long-term Body Weight Change Following the Switch to or the Addition of Integrase Inhibitors in Persons With Human Immunodeficiency Virus Differs by Sex by Lahiri, Cecile D, Mehta, C Christina, Yang, Qian, Maramba, Tsungirirai, Musonge-Effoe, Joffi, Yang, Chin-An, Dumond, Julie B, Alcaide, Maria L, Lake, Jordan E, Rubin, Leah H, French, Audrey L, Cocohoba, Jennifer, Kassaye, Seble G, Sharma, Anjali, Palella, Frank J, Mellors, John, Konkle-Parker, Deborah, Topper, Elizabeth, Augenbraun, Michael, Ali, Mohammed K, Sheth, Anandi N, Ziegler, Thomas R, Ofotokun, Igho, Alvarez, Jessica A

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Leveraging physiologically based pharmacokinetic modeling to optimize dosing for lopinavir/ritonavir with rifampin in pediatric patients by Salerno, Sara N., Capparelli, Edmund V., McIlleron, Helen, Gerhart, Jacqueline G., Dumond, Julie B., Kashuba, Angela D. M., Denti, Paolo, Gonzalez, Daniel

“…Study Objective Treatment of HIV and tuberculosis co‐infection leads to significant mortality in pediatric patients, and treatment can be challenging due to…”
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Consensus recommendations for the use of novel antiretrovirals in persons with HIV who are heavily treatment‐experienced and/or have multidrug‐resistant HIV‐1: Endorsed by the American Academy of HIV Medicine, American College of Clinical Pharmacy: An executive summary by Cluck, David B., Chastain, Daniel B., Murray, Milena, Durham, Spencer H., Chahine, Elias B., Derrick, Caroline, Dumond, Julie B., Hester, E. Kelly, Jeter, Sarah B., Johnson, Melissa D., Kilcrease, Christin, Kufel, Wesley D., Kwong, Jeffrey, Ladak, Amber F., Patel, Nimish, Pérez, Sarah E., Poe, Jonell B., Bolch, Charlotte, Thomas, Ian, Asiago‐Reddy, Elizabeth, Short, William R.

“…Treatment options are currently limited for persons with HIV‐1 (PWH) who are heavily treatment‐experienced and/or have multidrug‐resistant HIV‐1. Three agents…”
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Consensus recommendations for the use of novel antiretrovirals in persons with HIV who are heavily treatment‐experienced and/or have multidrug‐resistant HIV‐1: Endorsed by the American Academy of HIV Medicine, American College of Clinical Pharmacy by Cluck, David B., Chastain, Daniel B., Murray, Milena, Durham, Spencer H., Chahine, Elias B., Derrick, Caroline, Dumond, Julie B., Hester, E. Kelly, Jeter, Sarah B., Johnson, Melissa D., Kilcrease, Christin, Kufel, Wesley D., Kwong, Jeffrey, Ladak, Amber F., Patel, Nimish, Pérez, Sarah E., Poe, Jonell B., Bolch, Charlotte, Thomas, Ian, Asiago‐Reddy, Elizabeth, Short, William R.

“…Treatment options are currently limited for persons with HIV‐1 (PWH) who are heavily treatment‐experienced and/or have multidrug‐resistant HIV‐1. Three agents…”
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Population Modeling Highlights Drug Disposition Differences Between Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate in the Blood and Semen by Greene, Stephen A., Chen, Jingxian, Prince, Heather M. A., Sykes, Craig, Schauer, Amanda P., Blake, Kimberly, Nelson, Julie A. E., Gay, Cynthia L., Cohen, Myron S., Dumond, Julie B.

“…Understanding antiretroviral disposition in the male genital tract, a distinct viral compartment, can provide insight for the eradication of HIV. Population…”
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Pre-exposure prophylaxis for HIV prevention: how to predict success by Kashuba, Angela DM, Patterson, Kristine B, Dumond, Julie B, Cohen, Myron S

“…Powerful antiviral agents limited in their tissue penetration, intracellular metabolism, or tissue halflife are not appropriate for pre-exposure prophylaxis…”
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