Search Results - "Dummer, Patrick"

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice by Beckerman, Pazit, Bi-Karchin, Jing, Park, Ae Seo Deok, Qiu, Chengxiang, Dummer, Patrick D, Soomro, Irfana, Boustany-Kari, Carine M, Pullen, Steven S, Miner, Jeffrey H, Hu, Chien-An A, Rohacs, Tibor, Inoue, Kazunori, Ishibe, Shuta, Saleem, Moin A, Palmer, Matthew B, Cuervo, Ana Maria, Kopp, Jeffrey B, Susztak, Katalin

“…Risk variants of APOL1 associated with human chronic kidney disease have been identified, but causality has been unclear. Transgenic expression in mice now…”
Get full text

APOL1 toxin, innate immunity, and kidney injury by Limou, Sophie, Dummer, Patrick D, Nelson, George W, Kopp, Jeffrey B, Winkler, Cheryl A

“…The discovery that two common APOL1 alleles were strongly associated with nondiabetic kidney diseases in African descent populations led to hope for improved…”
Get more information

APOL1 Kidney Disease Risk Variants: An Evolving Landscape by Dummer, Patrick D., BA, Limou, Sophie, PhD, Rosenberg, Avi Z., MD, PhD, Heymann, Jurgen, PhD, Nelson, George, PhD, Winkler, Cheryl A., PhD, Kopp, Jeffrey B., MD

“…Summary Apolipoprotein L1 ( APOL1 ) genetic variants account for much of the excess risk of chronic and end-stage kidney disease, which results in a…”
Get full text

St18 specifies globus pallidus projection neuron identity in MGE lineage by Nunnelly, Luke F., Campbell, Melissa, Lee, Dylan I., Dummer, Patrick, Gu, Guoqiang, Menon, Vilas, Au, Edmund

“…The medial ganglionic eminence (MGE) produces both locally-projecting interneurons, which migrate long distances to structures such as the cortex as well as…”
Get full text

Endocytosis of albumin by podocytes elicits an inflammatory response and induces apoptotic cell death by Okamura, Kayo, Dummer, Patrick, Kopp, Jeffrey, Qiu, Liru, Levi, Moshe, Faubel, Sarah, Blaine, Judith

“…The presence of albuminuria is strongly associated with progression of chronic kidney disease. While albuminuria has been shown to injure renal proximal…”
Get full text

Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons by McKenzie, Melissa G., Cobbs, Lucy V., Dummer, Patrick D., Petros, Timothy J., Halford, Michael M., Stacker, Steven A., Zou, Yimin, Fishell, Gord J., Au, Edmund

“…GABAergic interneurons have many important functions in cortical circuitry, a reflection of their cell diversity. The developmental origins of this diversity…”
Get full text

Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and accelerate functional maturation of human stem cell-derived interneurons by Genestine, Matthieu, Ambriz, Daisy, Crabtree, Gregg W, Dummer, Patrick, Molotkova, Anna, Quintero, Michael, Mela, Angeliki, Biswas, Saptarshi, Feng, Huijuan, Zhang, Chaolin, Canoll, Peter, Hargus, Gunnar, Agalliu, Dritan, Gogos, Joseph A, Au, Edmund

“…Cortical interneurons establish inhibitory microcircuits throughout the neocortex and their dysfunction has been implicated in epilepsy and neuropsychiatric…”
Get full text

APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R by Okamoto, Koji, Rausch, Jason W., Wakashin, Hidefumi, Fu, Yulong, Chung, Joon-Yong, Dummer, Patrick D., Shin, Myung K., Chandra, Preeti, Suzuki, Kosuke, Shrivastav, Shashi, Rosenberg, Avi Z., Hewitt, Stephen M., Ray, Patricio E., Noiri, Eisei, Le Grice, Stuart F. J., Hoek, Maarten, Han, Zhe, Winkler, Cheryl A., Kopp, Jeffrey B.

“…APOL1 risk alleles associate with chronic kidney disease in African Americans, but the mechanisms remain to be fully understood. We show that APOL1 risk…”
Get full text

Unbiased Multidimensional Analysis Reveals Novel Principles of Cortical Interneuron Synaptic Organization by Dummer, Patrick Daniel

“…Neurons display exquisite specificity in synaptic connectivity, but we lack a complete understanding of neuronal connectivity and the rules that govern it. A…”
Get full text