Search Results - "Dumler, Inna"

Vascular smooth muscle cells initiate proliferation of mesenchymal stem cells by mitochondrial transfer via tunneling nanotubes by Vallabhaneni, Krishna C, Haller, Hermann, Dumler, Inna

“…Multipotent mesenchymal stem cells (MSCs) are promising candidates for regenerative cell-based therapy. The mechanisms underlying MSC differentiation and other…”
Get more information

oxLDL inhibits differentiation and functional activity of osteoclasts via scavenger receptor-A mediated autophagy and cathepsin K secretion by Dawodu, Damilola, Patecki, Margret, Hegermann, Jan, Dumler, Inna, Haller, Hermann, Kiyan, Yulia

“…Resorptive activity of osteoclasts is important for maintaining bone homeostasis. Endogenous compounds such as oxidized low density lipoprotein (oxLDL) have…”
Get full text

TLR4 Response to LPS Is Reinforced by Urokinase Receptor by Kiyan, Yulia, Tkachuk, Sergey, Rong, Song, Gorrasi, Anna, Ragno, Pia, Dumler, Inna, Haller, Hermann, Shushakova, Nelli

“…GPI-anchored uPAR is the receptor for the extracellular serine protease urokinase-type plasminogen activator (uPA). Though uPAR role in inflammatory processes…”
Get full text

Loss of urokinase receptor sensitizes cells to DNA damage and delays DNA repair by Narayanaswamy, Pavan B, Hodjat, Mahshid, Haller, Hermann, Dumler, Inna, Kiyan, Yulia

“…DNA damage induced by numerous exogenous or endogenous factors may have irreversible consequences on the cell leading to cell cycle arrest, senescence and cell…”
Get full text

Urokinase receptor mediates osteogenic differentiation of mesenchymal stem cells and vascular calcification via the complement C5a receptor by Kalbasi Anaraki, Parnian, Patecki, Margret, Larmann, Jan, Tkachuk, Sergey, Jurk, Kerstin, Haller, Hermann, Theilmeier, Gregor, Dumler, Inna

“…Vascular calcification is a severe consequence of several pathological processes with a lack of effective therapy. Recent studies suggest that circulating and…”
Get more information

Urokinase receptor mediates mobilization, migration, and differentiation of mesenchymal stem cells by VALLABHANENI, Krishna C, TKACHUK, Sergey, KIYAN, Yulia, SHUSHAKOVA, Nelli, HALLER, Hermann, DUMLER, Inna, EDEN, Gabriele

“…Multipotent mesenchymal stem cells (MSCs) have regenerative properties and are recognized as putative players in the pathogenesis of cardiovascular diseases…”
Get full text

Urokinase plasminogen activator (uPA) stimulates cholesterol biosynthesis in macrophages through activation of SREBP-1 in a PI3-kinase and MEK-dependent manner by Fuhrman, Bianca, Nitzan, Orna, Karry, Rachel, Volkova, Nina, Dumler, Inna, Aviram, Michael

“…Abstract Urokinase plasminogen activator (uPA) is expressed in human atherosclerotic lesions, predominantly in macrophages, and contributes to atherosclerosis…”
Get full text

CD2AP/CIN85 Balance Determines Receptor Tyrosine Kinase Signaling Response in Podocytes by Tossidou, Irini, Kardinal, Christian, Peters, Imke, Kriz, Wilhelm, Shaw, Andrey, Dikic, Ivan, Tkachuk, Sergej, Dumler, Inna, Haller, Hermann, Schiffer, Mario

“…Defects in podocyte signaling are the basis of many inherited glomerular diseases leading to glomerulosclerosis. CD2-associated protein (CD2AP) is highly…”
Get full text

Stat1 nuclear translocation by nucleolin upon monocyte differentiation by Jerke, Uwe, Tkachuk, Sergey, Kiyan, Julia, Stepanova, Victoria, Kusch, Angelika, Hinz, Michael, Dietz, Rainer, Haller, Hermann, Fuhrman, Bianca, Dumler, Inna

“…Members of the signal transducer and activator of transcription (Stat) family of transcription factors traverse the nuclear membrane through a specialized…”
Get full text

The tight junction protein ZO-2 mediates proliferation of vascular smooth muscle cells via regulation of Stat1 by Kusch, Angelika, Tkachuk, Sergey, Tkachuk, Natalia, Patecki, Margret, Park, Joon-Keun, Dietz, Rainer, Haller, Hermann, Dumler, Inna

“…Aims Recent evidence suggests that the zonula occludens protein 2 (ZO-2) might have additional cellular functions, beyond regulation of paracellular…”
Get full text

Urokinase-induced activation of the gp130/Tyk2/Stat3 pathway mediates a pro-inflammatory effect in human mesangial cells via expression of the anaphylatoxin C5a receptor by Shushakova, Nelli, Tkachuk, Natalia, Dangers, Marc, Tkachuk, Sergey, Park, Joon-Keun, Zwirner, Joerg, Hashimoto, Koji, Haller, Hermann, Dumler, Inna

“…Glomerular mesangial cells (MCs) are central to the pathogenesis of progressive glomeruli-associated renal diseases. However, molecular mechanisms underlying…”
Get full text

Urokinase-induced migration of human vascular smooth muscle cells requires coupling of the small GTPases RhoA and Rac1 to the Tyk2/PI3-K signalling pathway by Kiian, Ioulia, Tkachuk, Natalia, Haller, Hermann, Dumler, Inna

“…Urokinase-type plasminogen activator (uPA) facilitates cell migration by localizing proteolisys on the cell surface and by inducing intracellular signalling…”
Get more information

Mechanical stress modulates SOCS-1 expression in human vascular smooth muscle cells by Dangers, Marc, Kiyan, Julia, Grote, Karsten, Schieffer, Bernhard, Haller, Hermann, Dumler, Inna

“…The growth-promoting effect of mechanical stress on vascular smooth muscle cells (VSMC) has been implicated in the progress of cardiovascular diseases related…”
Get more information

The Jak/Stat Pathway and Urokinase Receptor Signaling in Human Aortic Vascular Smooth Muscle Cells by Dumler, Inna, Weis, Angelika, Mayboroda, Oleg A., Maasch, Christian, Jerke, Uwe, Haller, Hermann, Gulba, Dietrich C.

“…The binding of urokinase plasminogen activator (uPA) to its specific receptor (uPAR) facilitates migration of vascular smooth muscle cells (VSMC). However, the…”
Get full text

The Urokinase/Urokinase Receptor System Mediates the IgG Immune Complex-Induced Inflammation in Lung by Shushakova, Nelli, Eden, Gabriele, Dangers, Marc, Zwirner, Joerg, Menne, Jan, Gueler, Faikah, Luft, Friedrich C, Haller, Hermann, Dumler, Inna

“…Immune complex (IC) deposition induces an acute inflammatory response with tissue injury. IC-induced inflammation is mediated by inflammatory cell…”
Get full text

Urokinase Stimulates Human Vascular Smooth Muscle Cell Migration via a Phosphatidylinositol 3-Kinase-Tyk2 Interaction by Kusch, Angelika, Tkachuk, Sergey, Haller, Hermann, Dietz, Rainer, Gulba, Dietrich C., Lipp, Martin, Dumler, Inna

“…Janus kinases Jak1 and Tyk2 play an important role in urokinase-type plasminogen activator (uPA)-dependent signaling. We have recently demonstrated that both…”
Get full text

Urokinase-dependent Human Vascular Smooth Muscle Cell Adhesion Requires Selective Vitronectin Phosphorylation by Ectoprotein Kinase CK2 by Stepanova, Victoria, Jerke, Uwe, Sagach, Victoriya, Lindschau, Carsten, Dietz, Rainer, Haller, Hermann, Dumler, Inna

“…Urokinase (uPA)- and urokinase receptor (uPAR)-dependent cell adhesion to the extracellular matrix protein vitronectin (Vn) is an important event in wound…”
Get full text

oxLDL induces inflammatory responses in vascular smooth muscle cells via urokinase receptor association with CD36 and TLR4 by Kiyan, Yulia, Tkachuk, Sergey, Hilfiker-Kleiner, Denise, Haller, Hermann, Fuhrman, Bianca, Dumler, Inna

“…Abstract The pathogenesis of atherosclerosis involves an imbalanced lipid metabolism and a deregulated immune response culminating in chronic inflammation of…”
Get full text

oxLDL inhibits differentiation of mesenchymal stem cells into osteoblasts via the CD36 mediated suppression of Wnt signaling pathway by Dawodu, Damilola, Patecki, Margret, Dumler, Inna, Haller, Hermann, Kiyan, Yulia

“…Bone abnormalities as a consequence of osteoblast deregulation are associated with several diseases such as diabetes and chronic kidney disease. Important role…”
Get full text

Urokinase Induces Activation and Formation of Stat4 and Stat1-Stat2 Complexes in Human Vascular Smooth Muscle Cells by Dumler, Inna, Kopmann, Angela, Wagner, Kai, Mayboroda, Oleg A., Jerke, Uwe, Dietz, Rainer, Haller, Hermann, Gulba, Dietrich C.

“…Urokinase-type plasminogen activator (uPA) and its specific receptor (uPAR) act in concert to stimulate cytoplasmic signaling machinery and transcription…”
Get full text