Search Results - "Dumenco, LL"

The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase by DUMENCO, L. L, ALLAY, E, NORTON, K, GERSON, S. L

“…Nitrosoureas form O6-alkylguanine-DNA adducts that are converted to G to A transitions, the mutation found in the activated ras oncogenes of…”
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Retroviral Transduction and Expression of the Human Alkyltransferase cDNA Provides Nitrosourea Resistance to Hematopoietic Cells by Allay, James A., Dumenco, Luba L., Koc, Omer N., Liu, Lili, Gerson, Stanton L.

“…Myelosuppression is the dose-limiting toxicity for nitrosourea chemotherapy. This toxicity predominantly involves modification of the O6 position of guanine…”
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Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon by Zaidi, N H, Pretlow, T P, O'Riordan, M A, Dumenco, L L, Allay, E, Gerson, S L

“…Transgenic mice over-expressing MGMT, which codes for the human protein O6-alkylguanine-DNA alkyltransferase, are protected from methylating agent-induced…”
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Analysis of the tumorigenicity of the X gene of hepatitis B virus in a nontransformed hepatocyte cell line and the effects of cotransfection with a murine p53 mutant equivalent to human codon 249 by Oguey, D, Dumenco, LL, Pierce, RH, Fausto, N

“…Chronic infection with hepatitis B virus (HBV) is associated with the development of human hepatocellular carcinoma (HCC). One of the HBV genes, HBx, may have…”
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Analysis of the tumorigenicity of the X gene of hepatitis B virus in a nontransformed hepatocyte cell line and the effects of cotransfection with a murine p53 mutant equivalent to human codon 249 by Oguey, D, Dumenco, L L, Pierce, R H, Fausto, N

“…Chronic infection with hepatitis B virus (HBV) is associated with the development of human hepatocellular carcinoma (HCC). One of the HBV genes, HBx, may have…”
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Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine by Dolan, M E, Pegg, A E, Dumenco, L L, Moschel, R C, Gerson, S L

“…The inactivation of human and Escherichia coli O6-alkylguanine-DNA alkyltransferase by O6-methylguanine and O6-benzylguanine was compared. When HT29 cell…”
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The results of diagnostic studies for thrombophilia in a large group of patients with a personal or family history of thrombosis by DUMENCO, L. L, BLAIR, A. J, SWEENEY, J. D

“…The range of tests used in the evaluation of thrombophilia has been altered by the recent recognition of common genetic defects predisposing to thrombosis such…”
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Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6- benzylguanine plus BCNU by Gerson, SL, Phillips, W, Kastan, M, Dumenco, LL, Donovan, C

“…Human bone marrow (BM) cells contain low levels of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase, which may explain their susceptibility to…”
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Fetal Liver Hematopoietic Stem Cells As a Target for In Utero Retroviral Gene Transfer by Clapp, D.Wade, Dumenco, Luba L., Hatzoglou, Maria, Gerson, Stanton L.

“…Retroviral-mediated gene transfer into hematopoietic precur sors often results in only short-term gene transduction in vivo. Loss of the transduced genetic…”
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Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU by GERSON, S. L, PHILLIPS, W, KASTAN, M, DUMENCO, L. L, DONOVAN, C

“…Human bone marrow (BM) cells contain low levels of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase, which may explain their susceptibility to…”
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Specificity of bischloroethylnitrosourea-induced mutation in a Chinese hamster ovary cell line transformed to express human O6-alkylguanine-DNA alkyltransferase by MINNICK, D. T, GERSON, S. L, DUMENCO, L. L, VEIGL, M. L, SEDWICK, W. D

“…The human O6-alkylguanine-DNA alkyltransferase complementary DNA was transfected into the alkyltransferase-deficient Chinese hamster ovary cell line, D422, in…”
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The immature thymocyte is protected from N-methylnitrosourea-induced lymphoma by the human MGMT-CD2 transgene by Zaidi, N H, Allay, E, Ayi, T C, Li, B F, Dumenco, L L, Sy, M S, Gerson, S L

“…N-methylnitrosourea (MNU) induces thymic lymphoma in a high proportion of susceptible C57BL/6xSJL (C57/SJL) mice. Expression of the human DNA repair gene, MGMT…”
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Increase in nitrosourea resistance in mammalian cells by retrovirally mediated gene transfer of bacterial O6-alkylguanine-DNA alkyltransferase by Dumenco, L L, Warman, B, Hatzoglou, M, Lim, I K, Abboud, S L, Gerson, S L

“…Maloney murine leukemia virus-based, replication-defective retroviral vectors containing the neomycin resistance gene (neo) were developed to transfer the…”
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Fetal liver hematopoietic stem cells as a target for in utero retroviral gene transfer by Clapp, DW, Dumenco, LL, Hatzoglou, M, Gerson, SL

“…Retroviral-mediated gene transfer into hematopoietic precursors often results in only short-term gene transduction in vivo. Loss of the transduced genetic…”
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Enhanced repair of O6-methylguanine DNA adducts in the liver of transgenic mice expressing the ada gene by DUMENCO, L. L, ARCE, C, NORTON, K, JEUNG YUN, WAGNER, T, GERSON, S. L

“…The capacity to repair O6-methylguanine-DNA adducts was measured in the liver of transgenic mice expressing a chimeric gene consisting of the inducible…”
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Alkyltransferase transgenic mice: probes of chemical carcinogenesis by Gerson, S L, Zaidi, N H, Dumenco, L L, Allay, E, Fan, C Y, Liu, L, O'Connor, P J

“…Transgenic mice expressing DNA-repair genes are an instructive model with which to study the protective role of DNA-repair pathways in both spontaneous and…”
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Inhibition of the activation of Hageman factor (factor XII) and of platelet aggregation by extracts of Brugia malayi microfilariae by Foster, C B, Flanigan, T P, Kazura, J W, Dumenco, L L, Ratnoff, O D

“…In human filariasis, large numbers of blood-borne microfilariae circulate unimpeded through the blood stream. How intravascular filarial parasites avoid…”
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Inhibition of the activation of Hageman factor (factor XII) by extracts of Schistosoma mansoni by Foster, C B, Flanigan, T P, DeStigter, K K, Blanton, R, Dumenco, L L, Gallagher, C, Ratnoff, O D

“…How intravascular helminth parasites evade host hemostatic defense mechanisms and survive within the circulating blood has not been adequately explained…”
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Inhibition of the activation of Hageman factor (factor XII) by platelet factor 4 by Dumenco, L L, Everson, B, Culp, L A, Ratnoff, O D

“…Platelet factor 4 is a polypeptide constituent of platelet alpha granules that is released during platelet aggregation and inhibits heparin-mediated reactions…”
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