Search Results - "Dumelie, Jason G."

Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq by Dumelie, Jason G, Jaffrey, Samie R

“…R-loops are features of chromatin consisting of a strand of DNA hybridized to RNA, as well as the expelled complementary DNA strand. R-loops are enriched at…”
Get full text

A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis by Amadei, Gianluca, Zander, Mark A, Yang, Guang, Dumelie, Jason G, Vessey, John P, Lipshitz, Howard D, Smibert, Craig A, Kaplan, David R, Miller, Freda D

“…Here, we have asked about post-transcriptional mechanisms regulating murine developmental neurogenesis, focusing upon the RNA-binding proteins Smaug2 and…”
Get full text

Biomolecular condensates create phospholipid-enriched microenvironments by Dumelie, Jason G., Chen, Qiuying, Miller, Dawson, Attarwala, Nabeel, Gross, Steven S., Jaffrey, Samie R.

“…Proteins and RNA can phase separate from the aqueous cellular environment to form subcellular compartments called condensates. This process results in a…”
Get full text

Global regulation of mRNA translation and stability in the early Drosophila embryo by the Smaug RNA-binding protein by Chen, Linan, Dumelie, Jason G, Li, Xiao, Cheng, Matthew HK, Yang, Zhiyong, Laver, John D, Siddiqui, Najeeb U, Westwood, J Timothy, Morris, Quaid, Lipshitz, Howard D, Smibert, Craig A

“…BACKGROUND: Smaug is an RNA-binding protein that induces the degradation and represses the translation of mRNAs in the early Drosophila embryo. Smaug has two…”
Get full text

Characterizing the metabolomes of phase-separated condensates

“…Cells contain compartments composed of phase-separated protein condensates. We find that these condensates have a unique chemical microenvironment that…”
Get full text

Abstract 3270: Pan-cancer analysis of 1,962 whole-genomes reveals significantly mutated CTCF/cohesin insulators by Liu, Eric Minwei, Martinez-Fundichely, Alexander, Cuykendall, Tawny, Dumelie, Jason G., MacKay, Matthew, Dhingra, Priyanka, Jaffrey, Samie R., Khurana, Ekta

“…Abstract Recent studies have shown that mutations at non-coding elements, such as the TERT promoter and ESR1 enhancer, can act as cancer drivers. However, an…”
Get full text

Global regulation of mRNA translation and stability in the early Drosophilaembryo by the Smaug RNA-binding protein by Chen, Linan, Dumelie, Jason G, Li, Xiao, Cheng, Matthew HK, Yang, Zhiyong, Laver, John D, Siddiqui, Najeeb U, Westwood, J Timothy, Morris, Quaid, Lipshitz, Howard D, Smibert, Craig A

“…Abstract Background Smaug is an RNA-binding protein that induces the degradation and represses the translation of mRNAs in the early Drosophila embryo. Smaug…”
Get full text