Search Results - "Dumble, M"

The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells by Nishida, Y, Maeda, A, Kim, M J, Cao, L, Kubota, Y, Ishizawa, J, AlRawi, A, Kato, Y, Iwama, A, Fujisawa, M, Matsue, K, Weetall, M, Dumble, M, Andreeff, M, Davis, T W, Branstrom, A, Kimura, S, Kojima, K

“…Disease recurrence is the major problem in the treatment of acute myeloid leukemia (AML). Relapse is driven by leukemia stem cells, a chemoresistant…”
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511 Identification of a Small Molecule (PTC596) That Preferentially Depletes Tumor Stem Cells by Reducing Levels of Functional BMI1 Protein by Davis, T.W, Lee, S, Dumble, M, Sydorenko, N, Baiazitov, R, Jung, S, Sheedy, J, Weetall, M, Moon, Y.C, Cao, L.X

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Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma by Dumble, Melissa L., Croager, Emma J., Yeoh, George C.T., Quail, Elizabeth A

“…Oval cells are bipotential liver stem cells able to differentiate into hepatocytes and bile duct epithelia. In normal adult liver oval cells are quiescent,…”
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A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver by Akhurst, Barbara, Croager, Emma J., Farley-Roche, Caroline A., Ong, Jin Kar, Dumble, Melissa L., Knight, Belinda, Yeoh, George C.

“…Several reliable and reproducible methods are available to induce oval cells in rat liver. Effective methods often involve inhibiting proliferation in…”
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357 (PB345): Discovery and development of IMP1734 (EIK1003), a potent and selective PARP1 inhibitor by Cai, S.X., Ma, N., Wang, X., Zhao, Y., Zhou, R., Jiang, Y., Chen, M., Tian, Y.E., Krishnan, S., Dumble, M.

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53 Down regulation of beta-catenin by a locked nucleic acid oligonucleotide antagonist inhibits tumor growth in experimental models of human cancer by Dumble, M, Zhang, Y, Zhu, P, Kim, S, Qu, Z, Shi, V, Kearney, J, Greenberger, L.M, Horak, I.D

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218 Down-modulation of the androgen receptor (AR) with EZN-4176 inhibits the growth of prostate tumor and potentiates the inhibitory effect of MDV-3100, a novel anti-androgen by Zhang, Y, Castaneda, S, Kim, S, Qu, Z, Kraft, P, Wang, M, Dumble, M, Zhao, H, Greenberger, L, Horak, I

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131 (PB119): Novel Androgen Receptor Antagonists with Improved Activity Against Common LBD Variants Associated with Therapeutic Resistance by Malik, R., Li, Y., Kirkeby, E., Tummala, P., Pino, N., Rasper, D., Chang, X., Pacifici, N., Scott, M., Zheng, L., Allegretti, P., Song, L., Murnock, D., Tabatabaei, A., Cleary, L., Tang, Y., Dumble, M., Kumar, P., Piotrowski, D., Therien, A.

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Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice by Nannenga, Bonnie, Lu, Xiongbin, Dumble, Melissa, Van Maanen, Marc, Nguyen, Thuy-Ai, Sutton, Richard, Kumar, T. Rajendra, Donehower, Lawrence A.

“…The p53‐induced serine/threonine phosphatase, protein phosphatase 1D magnesium‐dependent, delta isoform (PPM1D) (or wild‐type p53‐induced phosphatase 1…”
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Insights into Aging Obtained from p53 Mutant Mouse Models by DUMBLE, MELISSA, GATZA, CATHERINE, TYNER, STUART, VENKATACHALAM, SUNDARESAN, DONEHOWER, LAWRENCE A.

“…: Cancer suppression is an integral component of longevity in organisms with renewable tissues. A number of genes in the mammalian genome function in cancer…”
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Hepatoblast-like cells populate the adult p53 knockout mouse liver : Evidence for a hyperproliferative, maturation-arrested stem cell compartment by DUMBLE, Melissa L, KNIGHT, Belinda, QUAIL, Elizabeth A, YEOH, George C. T

“…Although p53 regulates the cell cycle and apoptosis, gross embryonic development is normal in the p53 knockout (-/-) mouse. In this study, we comprehensively…”
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