Search Results - "Dumas, Jacques"

Deep Learning-Based Extreme Heatwave Forecast by Jacques-Dumas, Valérian, Ragone, Francesco, Borgnat, Pierre, Abry, Patrice, Bouchet, Freddy

“…Because of the impact of extreme heat waves and heat domes on society and biodiversity, their study is a key challenge. We specifically study long-lasting…”
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Data-driven methods to estimate the committor function in conceptual ocean models by Jacques-Dumas, Valérian, van Westen, René M, Bouchet, Freddy, Dijkstra, Henk A

“…In recent years, several climate subsystems have been identified that may undergo a relatively rapid transition compared to the changes in their forcing. Such…”
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Discovery and development of sorafenib: a multikinase inhibitor for treating cancer by Wilhelm, Scott, Carter, Christopher, Lynch, Mark, Lowinger, Timothy, Dumas, Jacques, Smith, Roger A, Schwartz, Brian, Simantov, Ronit, Kelley, Susan

“…Since the molecular revolution of the 1980s, knowledge of the aetiology of cancer has increased considerably, which has led to the discovery and development of…”
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Crystal structure of penicillin-binding protein 3 (PBP3) from Escherichia coli by Sauvage, Eric, Derouaux, Adeline, Fraipont, Claudine, Joris, Marine, Herman, Raphaël, Rocaboy, Mathieu, Schloesser, Marie, Dumas, Jacques, Kerff, Frédéric, Nguyen-Distèche, Martine, Charlier, Paulette

“…In Escherichia coli, penicillin-binding protein 3 (PBP3), also known as FtsI, is a central component of the divisome, catalyzing cross-linking of the cell wall…”
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The impact of proline isomerization on antigen binding and the analytical profile of a trispecific anti-HIV antibody by Masiero, Alessandro, Nelly, Lechat, Marianne, Gentric, Christophe, Sourrouille, Florian, Laville, Ronan, Crépin, Claire, Borel, Cornelia, Ziegler, Grégoire, Bisch, Eric, Leclerc, Ludovic, Laurent, Dominique, Brault, Sylvie, Alexandre, Marie, Gagnaire, Francis, Duffieux, Fabienne, Soubrier, Cécile, Capdevila, Isabelle, Arnould, Jacques, Dumas, Jérôme, Dabin, Bruno, Genet, Katarina, Radošević, Jean-Michel, Menet, Catherine, Prades

“…Proline conformational isomerization is a mechanism that affects different types of protein functions and behaviors. Using analytical characterization,…”
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Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-c]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone by Vallée, François, Carrez, Chantal, Pilorge, Fabienne, Dupuy, Alain, Parent, Annick, Bertin, Luc, Thompson, Fabienne, Ferrari, Paul, Fassy, Florence, Lamberton, Annabelle, Thomas, Anne, Arrebola, Rosalia, Guerif, Stéphane, Rohaut, Alexandre, Certal, Victor, Ruxer, Jean-Marie, Delorme, Cécile, Jouanen, Alain, Dumas, Jacques, Grépin, Claudine, Combeau, Cécile, Goulaouic, Hélène, Dereu, Norbert, Mikol, Vincent, Mailliet, Patrick, Minoux, Hervé

“…A novel class of heat shock protein 90 (Hsp90) inhibitors was developed after a low throughput screen (LTS) of a focused library containing approximately 21K…”
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Cell division in cocci: localization and properties of the Streptococcus pneumoniae FtsA protein by Lara, Beatriz, Rico, Ana Isabel, Petruzzelli, Sabrina, Santona, Antonella, Dumas, Jacques, Biton, Jacques, Vicente, Miguel, Mingorance, Jesús, Massidda, Orietta

“…Summary We studied the cytological and biochemical properties of the FtsA protein of Streptococcus pneumoniae. FtsA is a widespread bacterial cell division…”
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Design and discovery of small molecules targeting raf-1 kinase by Lowinger, Timothy B, Riedl, Bernd, Dumas, Jacques, Smith, Roger A

“…Raf kinase, an enzyme which acts downstream in the Ras signaling pathway, is involved in cancerous cell proliferation. Thus, small molecule inhibitors of Raf…”
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Recent advances in the research and development of RAF kinase inhibitors by Smith, Roger A, Dumas, Jacques, Adnane, Lila, Wilhelm, Scott M

“…The RAS-RAF-MEK-ERK signaling pathway (ERK pathway) plays a key role in tumorigenesis and cancer progression. Mutations of RAS or B-RAF lead to a constitutive…”
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Contribution of small mountainous rivers to particulate organic carbon input in the Bay of Biscay by Coynel, A, Etcheber, H, Abril, G, Maneux, E, Dumas, J, Hurtrez, J.E

“…The Nivelle River, a typical Pyrenean mountainous watershed reaching the Bay of Biscay (Atlantic Ocean), was sampled with high resolution during 1996. The…”
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A Scaleable Synthesis of BAY 43-9006:  A Potent Raf Kinase Inhibitor for the Treatment of Cancer by Bankston, Donald, Dumas, Jacques, Natero, Reina, Riedl, Bernd, Monahan, Mary-Katherine, Sibley, Robert

“…Urea 3 (BAY 43 - 9006), a potent Raf kinase inhibitor, was prepared in four steps with an overall yield of 63%. Significant process research enabled isolation…”
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Comparison of non-parametric and parametric water temperature models on the Nivelle River, France by BENYAHYA, LOUBNA, ST-HILAIRE, ANDRÉ, OUARDA, TAHA B. M. J., BOBÉE, BERNARD, DUMAS, JACQUES

“…Water temperature is an important abiotic variable in aquatic habitat studies and may be one of the factors limiting the potential fish habitat (e.g…”
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Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors by Dumas, Jacques, Brittelli, David, Chen, Jinshan, Dixon, Brian, Hatoum-Mokdad, Holia, König, Gerhard, Sibley, Robert, Witowsky, James, Wong, Stephen

“…Cathepsin D, a lysosomal aspartyl protease, has been implicated in the pathology of Alzheimer's disease as well as breast and ovarian cancer. A weakly active…”
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SAR of a novel ‘Anthranilamide Like’ series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer by Wickens, Philip, Kluender, Harold, Dixon, Julie, Brennan, Catherine, Achebe, Furahi, Bacchiocchi, Antonella, Bankston, Don, Bierer, Donald, Brands, Michael, Braun, Debbie, Brown, Melissa S., Chuang, Chih-Yuan, Dumas, Jacques, Enyedy, Istvan, Hofilena, Gloria, Hong, Zhenqiu, Housley, Tim, Jones, Benjamin, Khire, Uday, Kreiman, Charles, Kumarasinghe, Ellalahewage, Lowinger, Timothy, Ott-Morgan, Ronda, Perkins, Louise, Phillips, Barton, Schoenleber, Robert, Scott, William J., Sheeler, Ryan, Redman, Anikó, Sun, Xiuying, Taylor, Ian, Wang, Lei, Wilhelm, Scott, Zhang, Xiaomei, Zhang, Mingbao, Sullivan, Elizabeth, Carter, Christopher, Miglarese, Mark, Levy, Joan

“…Novel series of anthranilamide type molecules that are active as inhibitors of B-RAF, c-KIT, and VEGFR-2 were identified. Novel anthranilamides were…”
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Regorafenib (BAY 73‐4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity by Wilhelm, Scott M., Dumas, Jacques, Adnane, Lila, Lynch, Mark, Carter, Christopher A., Schütz, Gunnar, Thierauch, Karl‐Heinz, Zopf, Dieter

“…Angiogenesis, a critical driver of tumor development, is controlled by interconnected signaling pathways. Vascular endothelial growth factor receptor (VEGFR) 2…”
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Preparation of 5-Substituted 3-Aminofuran-2-carboxylate Esters by Redman, Anikó M, Dumas, Jacques, Scott, William J

“…An efficient method for the preparation of 3-aminofuran-2-carboxylate esters has been developed. This method is based on the reaction of an α-cyanoketone with…”
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A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients by Cassotta, Antonino, Mikol, Vincent, Bertrand, Thomas, Pouzieux, Stéphanie, Le Parc, Josiane, Ferrari, Paul, Dumas, Jacques, Auer, Michael, Deisenhammer, Florian, Gastaldi, Matteo, Franciotta, Diego, Silacci-Fregni, Chiara, Fernandez Rodriguez, Blanca, Giacchetto-Sasselli, Isabella, Foglierini, Mathilde, Jarrossay, David, Geiger, Roger, Sallusto, Federica, Lanzavecchia, Antonio, Piccoli, Luca

“…Natalizumab (NZM), a humanized monoclonal IgG4 antibody to α4 integrins, is used to treat patients with relapsing-remitting multiple sclerosis (MS) 1 , 2 , but…”
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Eravacycline Is Active against Bacterial Isolates Expressing the Polymyxin Resistance Gene mcr-1 by Fyfe, Corey, LeBlanc, Gabrielle, Close, Brianna, Nordmann, Patrice, Dumas, Jacques, Grossman, Trudy H

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Developability assessment by Dumas, Jacques, Huille, Sylvain, Prades, Catherine

“…The therapeutic antibodies and their by-products (antibody fragments, conjugated, etc.) establish one of the most dynamic biopharmaceutical market segments…”
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Albumin binding Nanofitins, a new scaffold to extend half-life of biologics – a case study with exenatide peptide by Michot, Nadine, Guyochin, Aurélia, Cinier, Mathieu, Savignard, Chloé, Kitten, Olivier, Pascual, Marie-Hélène, Pouzieux, Stéphanie, Ozoux, Marie-Laure, Verdier, Patrick, Vicat, Pascale, Dumas, Jacques

“…A new strategy of peptide half-life extension has been evaluated. We investigated libraries of a small and very stable protein scaffold called Nanofitin,…”
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