Search Results - "Duman, Catharine H"

Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior by Wohleb, Eric S., Terwilliger, Rosemarie, Duman, Catharine H., Duman, Ronald S.

“…Chronic stress exposure causes neuronal atrophy and synaptic deficits in the medial prefrontal cortex (PFC), contributing to development of anxiety- and…”
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N-Methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effects by Fogaça, Manoela V, Fukumoto, Kenichi, Franklin, Tina, Liu, Rong-Jian, Duman, Catharine H, Vitolo, Ottavio V, Duman, Ronald S

“…Currently available antidepressants have a delayed onset and limited efficacy, highlighting the need for new, rapid and more efficacious agents. Ketamine, an…”
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Ketamine rapidly reverses stress-induced impairments in GABAergic transmission in the prefrontal cortex in male rodents by Ghosal, Sriparna, Duman, Catharine H., Liu, Rong-Jian, Wu, Min, Terwilliger, Rosemarie, Girgenti, Matthew J., Wohleb, Eric, Fogaca, Manoela V., Teichman, Emily M., Hare, Brendan, Duman, Ronald S.

“…Dysfunction of medial prefrontal cortex (mPFC) in association with imbalance of inhibitory and excitatory neurotransmission has been implicated in depression…”
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Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT1A receptor stimulation by Fukumoto Kenichi, Fogaça Manoela V, Rong-Jian, Liu, Duman, Catharine H, Xiao-Yuan, Li, Chaki Shigeyuki, Duman, Ronald S

“…We previously reported that the serotonergic system is important for the antidepressant-like effects of ketamine, a non-competitive N-methyl-D-aspartate…”
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A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment by Duman, Catharine H, Schlesinger, Lee, Kodama, Masafumi, Russell, David S, Duman, Ronald S

“…Background Brain-derived neurotrophic factor (BDNF) is upregulated in the hippocampus by antidepressant treatments, and centrally administered BDNF can produce…”
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Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise by Duman, Catharine H., Schlesinger, Lee, Terwilliger, Rosemarie, Russell, David S., Newton, Samuel S., Duman, Ronald S.

“…Growth factors in the brain are important to depression and it's treatment and we assessed the ability of peripherally administered insulin-like growth…”
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Erythropoietin Induction by Electroconvulsive Seizure, Gene Regulation, and Antidepressant-Like Behavioral Effects by Girgenti, Matthew J, Hunsberger, Joshua, Duman, Catharine H, Sathyanesan, Monica, Terwilliger, Rose, Newton, Samuel S

“…Background The neuroprotective and trophic actions of erythropoietin (EPO) have been tested in several animal models of insult, injury, and neurodegeneration…”
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Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation by Kato, Taro, Pothula, Santosh, Liu, Rong-Jian, Duman, Catharine H., Terwilliger, Rosemarie, Vlasuk, George P., Saiah, Eddine, Hahm, Seung, Duman, Ronald S.

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GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions by Gerhard, Danielle M, Pothula, Santosh, Liu, Rong-Jian, Wu, Min, Li, Xiao-Yuan, Girgenti, Matthew J, Taylor, Seth R, Duman, Catharine H, Delpire, Eric, Picciotto, Marina, Wohleb, Eric S, Duman, Ronald S

“…A single subanesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces rapid and sustained antidepressant actions in depressed patients,…”
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Models of Depression by Duman, Catharine H.

“…The incidence of depressive illness is high in the United States and worldwide, and the inadequacy of currently available drug treatments contributes to the…”
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Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation by Kato, Taro, Pothula, Santosh, Liu, Rong-Jian, Duman, Catharine H, Terwilliger, Rosemarie, Vlasuk, George P, Saiah, Eddine, Hahm, Seung, Duman, Ronald S

“…Preclinical studies demonstrate that rapid acting antidepressants, including ketamine require stimulation of mTORC1 signaling. This pathway is regulated by…”
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Spine synapse remodeling in the pathophysiology and treatment of depression by Duman, Catharine H., Duman, Ronald S.

“…Clinical brain imaging and postmortem studies provide evidence of structural and functional abnormalities of key limbic and cortical structures in depressed…”
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Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice by Duman, Catharine H, Schlesinger, Lee, Russell, David S, Duman, Ronald S

“…Abstract Reports of beneficial effects of exercise on psychological health in humans are increasingly supported by basic research studies. Exercise is…”
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Antidepressant actions of the exercise-regulated gene VGF by Duman, Ronald S, Hunsberger, Joshua G, Newton, Samuel S, Bennett, Alicia H, Duman, Catharine H, Russell, David S, Salton, Stephen R

“…Exercise has many health benefits, including antidepressant actions in depressed human subjects, but the mechanisms underlying these effects have not been…”
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TNFα Signaling in Depression and Anxiety: Behavioral Consequences of Individual Receptor Targeting by Simen, Birgitte B., Duman, Catharine H., Simen, Arthur A., Duman, Ronald S.

“…Increased serum levels of TNF α and other pro-inflammatory cytokines have been found in patients with major depression and several other psychiatric…”
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Stress-induced neuronal CSF1 provokes microglia-mediated neuronal remodeling and depressive-like behavior by Wohleb, Eric S, Terwilliger, Rosemarie, Duman, Catharine H, Duman, Ronald S

“…Abstract Background Chronic stress exposure causes neuronal atrophy and synaptic deficits in the medial prefrontal cortex (PFC), contributing to development of…”
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Evaluating effects of EPO in rodent behavioral assays related to depression by Duman, Catharine H, Newton, Samuel S

“…The cytokine erythropoietin (EPO) is an important regulator of hematopoesis and has well-known tissue protective properties. Neurotrophic action is implicated…”
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Fear conditioning and latent inhibition in mice lacking the high affinity subclass of nicotinic acetylcholine receptors in the brain by Caldarone, Barbara J, Duman, Catharine H, Picciotto, Marina R

“…Nicotine can enhance performance in several tests of cognition but the specific nicotinic receptor subtypes mediating these effects are largely unknown. Knock…”
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Corrigendum to “Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice” [Brain Res. 1199 (2008) 148–158] by Duman, Catharine H, Schlesinger, Lee, Russell, David S, Duman, Ronald S

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Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORCI activation by Kato, Taro, Pothula, Santosh, Liu, Rong-Jian, Duman, Catharine H, Terwilliger, Rosemarie, Vlasuk, George P, Saiah, Eddine, Hahm, Seung, Duman, Ronald S

“…Preclinical studies demonstrate that rapid-acting antidepressants, including ketamine, require stimulation of mTORC1 signaling. This pathway is regulated by…”
Get full text