Search Results - "Dumènil, Dominique"

Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-β signaling at the bipotent erythro-megakaryocytic progenitor stage by Randrianarison-Huetz, Voahangy, Laurent, Benoit, Bardet, Valérie, Blobe, Gerard C., Huetz, François, Duménil, Dominique

“…Growth factor independence-1B (Gfi-1B) is a transcriptional repressor essential for erythropoiesis and megakaryopoiesis. Targeted gene disruption of GFI1B in…”
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A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain by Laurent, Benoît, Randrianarison-Huetz, Voahangy, Frisan, Emilie, Andrieu-Soler, Charlotte, Soler, Eric, Fontenay, Michaela, Dusanter-Fourt, Isabelle, Duménil, Dominique

“…Gfi-1B is a transcriptional repressor essential for the regulation of erythropoiesis and megakaryopoiesis. Here we identify Gfi-1B p32, a Gfi-1B isoform, as…”
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High-mobility group protein HMGB2 regulates human erythroid differentiation through trans-activation of GFI1B transcription by Laurent, Benoît, Randrianarison-Huetz, Voahangy, Maréchal, Vincent, Mayeux, Patrick, Dusanter-Fourt, Isabella, Duménil, Dominique

“…Gfi-1B is a transcriptional repressor that is crucial for erythroid differentiation: inactivation of the GFI1B gene in mice leads to embryonic death due to…”
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The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation by Capron, Claude, Lécluse, Yann, Kaushik, Anna Lila, Foudi, Adlen, Lacout, Catherine, Sekkai, Dalila, Godin, Isabelle, Albagli, Olivier, Poullion, Isabelle, Svinartchouk, Fedor, Schanze, Elisabeth, Vainchenker, William, Sablitzky, Fred, Bennaceur-Griscelli, Annelise, Duménil, Dominique

“…Hematopoietic stem cells (HSCs) arise, self-renew, or give rise to all hematopoietic lineages through the effects of transcription factors activated by…”
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Protein Kinase C Mediates the Mitogenic Action of Thrombopoietin in c-Mpl–Expressing UT-7 Cells by Hong, Ying, Dumènil, Dominique, van der Loo, Bernd, Goncalves, Frédérique, Vainchenker, William, Erusalimsky, Jorge D.

“…Protein kinase C (PKC) has been implicated in signal transduction events elicited by several hematopoietic growth factors. Thrombopoietin (TPO) is the major…”
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β-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferation by Meyer, Laure, Deau, Bénédicte, Forejtníková, Hana, Duménil, Dominique, Margottin-Goguet, Florence, Lacombe, Catherine, Mayeux, Patrick, Verdier, Frédérique

“…Control of intensity and duration of erythropoietin (Epo) signaling is necessary to tightly regulate red blood cell production. We have recently shown that the…”
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Protein Kinase C Mediates the Mitogenic Action of Thrombopoietin in c-Mpl–Expressing UT-7 Cells by Hong, Ying, Dumènil, Dominique, van der Loo, Bernd, Goncalves, Frédérique, Vainchenker, William, Erusalimsky, Jorge D.

“…Protein kinase C (PKC) has been implicated in signal transduction events elicited by several hematopoietic growth factors. Thrombopoietin (TPO) is the major…”
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A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome by Lacout, Catherine, Haddad, Elie, Sabri, Siham, Svinarchouk, Fedor, Garçon, Loic, Capron, Claude, Foudi, Adlen, Mzali, Rym, Snapper, Scott B., Louache, Fawzia, Vainchenker, William, Duménil, Dominique

“…A defect in cell trafficking and chemotaxis plays an important role in the immune deficiency observed in Wiskott-Aldrich syndrome (WAS). In this report, we…”
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Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells by Garçon, Loïc, Lacout, Catherine, Svinartchouk, Fédor, Le Couédic, Jean-Pierre, Villeval, Jean-Luc, Vainchenker, William, Duménil, Dominique

“…Growth factor independence-1B (Gfi-1B) is a transcription factor with a highly conserved transcriptional repressor snail–Gfi-1 (SNAG) domain and 6 zinc-finger…”
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Gfi‐1B Promoter Remains Associated with Active Chromatin Marks Throughout Erythroid Differentiation of Human Primary Progenitor Cells by Laurent, Benoît, Randrianarison‐Huetz, Voahangy, Kadri, Zahra, Roméo, Paul‐Henri, Porteu, Françoise, Duménil, Dominique

“…Growth Factor Independent‐1B (Gfi‐1B) is a transcriptional repressor that plays critical roles in the control of erythropoiesis and megakaryopoiesis. Gfi‐1B…”
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LYL-1 deficiency induces a stress erythropoiesis by Capron, Claude, Lacout, Catherine, Lécluse, Yann, Wagner-Ballon, Orianne, Kaushik, Anna-Lila, Cramer-Bordé, Elisabeth, Sablitzky, Fred, Duménil, Dominique, Vainchenker, William

“…Objective LYL-1 is a transcription factor containing a basic helix-loop-helix motif closely related to SCL/TAL-1, a regulator of erythroid differentiation…”
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ETO2 coordinates cellular proliferation and differentiation during erythropoiesis by Goardon, Nicolas, Lambert, Julie A, Rodriguez, Patrick, Nissaire, Philippe, Herblot, Sabine, Thibault, Pierre, Dumenil, Dominique, Strouboulis, John, Romeo, Paul-Henri, Hoang, Trang

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Impaired Erythropoiesis in LYL-1 Deficient Mice by Capron, Claude, Lacout, Catherine, Lecluse, Yann, Wagner-Ballon, Orianne, Kaushik, Anna Lila, Bordé, Elisabeth Cramer, Sablitzky, Fred, Duménil, Dominique, Vainchenker, William

“…LYL-1 is a basic Helix-Loop-Helix (bHLH) transcription factor closely related to TAL. Both LYL-1 and TAL were originally identified through their implication…”
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Distinct effects of thrombopoietin depending on a threshold level of activated Mpl in BaF-3 cells by Millot, Gaël A, Vainchenker, William, Duménil, Dominique, Svinarchuk, Fédor

“…Thrombopoietin (TPO) plays a critical role in megakaryopoiesis through binding to its receptor Mpl. This involves activation of various intracellular signaling…”
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lyl-1 and tal-1/ scl, two genes encoding closely related bHLH transcription factors, display highly overlapping expression patterns during cardiovascular and hematopoietic ontogeny by Giroux, Sébastien, Kaushik, Anna-Lila, Capron, Claude, Jalil, Ali, Kelaidi, Charikleia, Sablitzky, Fred, Dumenil, Dominique, Albagli, Olivier, Godin, Isabelle

“…The TAL-1/ SCL and LYL-1 genes encode two closely related basic helix–loop–helix transcription factors involved in child T-acute lymphoblastic leukemia through…”
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Thrombopoietin does not induce lineage-restricted commitment of Mpl-R expressing pluripotent progenitors but permits their complete erythroid and megakaryocytic differentiation by GONCALVES, F, LACOUT, C, VILLEVAL, J.-L, WENDLING, F, VAINCHENKER, W, DUMENIL, D

“…In this study, we examined the in vitro and in vivo effects of forced expression of Mpl-R (the thrombopoietin receptor) on the progeny of murine hematopoietic…”
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La famille des répresseurs transcriptionnels Gfi-1 dans la régulation de l'hématopoïèse by LAURENT, Benoit, RANDRIANARISON, Voahangy, DUMENIL, Dominique

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Ectopic expression of the erythropoietin receptor in a murine interleukin-6-dependent plasmacytoma cell line (TEPC-2027) confers proliferative responsiveness to erythropoietin by FEGER, F, DUBART, A, LACOUT, C, DUSANTER-FOURT, I, MAYEUX, P, VAINCHENKER, W, DUMENIL, D

“…To compare the signal transduction pathways used by erythropoietin (Epo) and interleukin-6 (IL-6), the cDNA for the murine Epo receptor (Epo-R) was introduced…”
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ETO2 coordinates cellular proliferation and differentiation during erythropoiesis by Goardon, Nicolas, Lambert, Julie A, Rodriguez, Patrick, Nissaire, Philippe, Herblot, Sabine, Thibault, Pierre, Dumenil, Dominique, Strouboulis, John, Romeo, Paul‐Henri, Hoang, Trang

“…The passage from proliferation to terminal differentiation is critical for normal development and is often perturbed in malignancies. To define the molecular…”
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High-mobility group protein HMGB2 regulates human erythroid differentiation through trans-activation of GFIIB transcription by LAURENT, Benoit, RANDRIANARISON-HUETZ, Voahangy, MAREHAL, Vincent, MAYEUX, Patrick, DUSANTER-FOURT, Isabella, DUMENIL, Dominique

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