Search Results - "Duluc, Lucie"

Rho GTPases in the regulation of pulmonary vascular barrier function by Duluc, Lucie, Wojciak-Stothard, Beata

“…Pulmonary endothelial permeability is an important determinant of vascular adaptation to changes in oxygen tension, blood pressure, levels of growth factors or…”
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Microparticles from patients with metabolic syndrome induce vascular hypo-reactivity via Fas/Fas-ligand pathway in mice by Agouni, Abdelali, Ducluzeau, Pierre-Henri, Benameur, Tarek, Faure, Sébastien, Sladkova, Martina, Duluc, Lucie, Leftheriotis, Georges, Pechanova, Olga, Delibegovic, Mirela, Martinez, Maria Carmen, Andriantsitohaina, Ramaroson

“…Microparticles are membrane vesicles with pro-inflammatory properties. Circulating levels of microparticles have previously been found to be elevated in…”
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Propionyl-L-carnitine corrects metabolic and cardiovascular alterations in diet-induced obese mice and improves liver respiratory chain activity by Mingorance, Carmen, Duluc, Lucie, Chalopin, Matthieu, Simard, Gilles, Ducluzeau, Pierre-Henri, Herrera, Maria Dolores, Alvarez de Sotomayor, Maria, Andriantsitohaina, Ramaroson

“…Obesity is a primary contributor to acquired insulin resistance leading to the development of type 2 diabetes and cardiovascular alterations. The carnitine…”
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Extract Enriched in Flavan-3-ols and Mainly Procyanidin Dimers Improves Metabolic Alterations in a Mouse Model of Obesity-Related Disorders Partially via Estrogen Receptor Alpha by Leonetti, Daniela, Soleti, Raffaella, Clere, Nicolas, Vergori, Luisa, Jacques, Caroline, Duluc, Lucie, Dourguia, Catherine, Martínez, Maria C, Andriantsitohaina, Ramaroson

“…Red wine polyphenol extracts improve cardiovascular and metabolic disorders linked to obesity. Their vascular protection is mediated by the activation of the…”
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Biopterin metabolism and eNOS expression during hypoxic pulmonary hypertension in mice by Dubois, Mathilde, Delannoy, Estelle, Duluc, Lucie, Closs, Ellen, Li, Huige, Toussaint, Christian, Gadeau, Alain-Pierre, Gödecke, Axel, Freund-Michel, Véronique, Courtois, Arnaud, Marthan, Roger, Savineau, Jean-Pierre, Muller, Bernard

“…Tetrahydrobiopterin (BH4), which fosters the formation of and stabilizes endothelial NO synthase (eNOS) as an active dimer, tightly regulates eNOS coupling /…”
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Neutrophil Extracellular Traps Promote Angiogenesis: Evidence From Vascular Pathology in Pulmonary Hypertension by Aldabbous, Lulwah, Abdul-Salam, Vahitha, McKinnon, Tom, Duluc, Lucie, Pepke-Zaba, Joanna, Southwood, Mark, Ainscough, Alexander J, Hadinnapola, Charaka, Wilkins, Martin R, Toshner, Mark, Wojciak-Stothard, Beata

“…OBJECTIVE—Inflammation and dysregulated angiogenesis are features of endothelial dysfunction in pulmonary hypertension. Neutrophil extracellular traps (NETs),…”
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Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation by Dowsett, Laura, Duluc, Lucie, Higgins, Erin, Alghamdi, Fatmah, Fast, Walter, Salt, Ian P., Leiper, James

“…Asymmetric dimethylarginine (ADMA) is generated through the irreversible methylation of arginine residues. It is an independent risk factor for cardiovascular…”
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Delphinidin inhibits VEGF induced-mitochondrial biogenesis and Akt activation in endothelial cells by Duluc, Lucie, Jacques, Caroline, Soleti, Raffaella, Andriantsitohaina, Ramaroson, Simard, Gilles

“…Delphinidin, an anthocyanin present in red wine, has been reported to exert vasculoprotective properties on endothelial cells, including vasorelaxing and…”
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Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis by Perdomo, Liliana, Vidal-Gómez, Xavier, Soleti, Raffaella, Vergori, Luisa, Duluc, Lucie, Chwastyniak, Maggy, Bisserier, Malik, Le Lay, Soazig, Villard, Alexandre, Simard, Gilles, Meilhac, Olivier, Lezoualc’h, Frank, Khantalin, Ilya, Veerapen, Reuben, Dubois, Séverine, Boursier, Jérôme, Henni, Samir, Gagnadoux, Frédéric, Pinet, Florence, Andriantsitohaina, Ramaroson, Martínez, M. Carmen

“…RATIONALE:Metabolic syndrome (MetS) is a cluster of interrelated risk factors for cardiovascular diseases and atherosclerosis. Circulating levels of large…”
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miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia by Iannone, Lucio, Zhao, Lan, Dubois, Olivier, Duluc, Lucie, Rhodes, Christopher J, Wharton, John, Wilkins, Martin R, Leiper, James, Wojciak-Stothard, Beata

“…The NOS (nitric oxide synthase) inhibitor ADMA (asymmetric dimethylarginine) contributes to the pathogenesis of pulmonary hypertension. Reduced levels of the…”
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Modulation of mitochondrial capacity and angiogenesis by red wine polyphenols via estrogen receptor, NADPH oxidase and nitric oxide synthase pathways by Duluc, Lucie, Jacques, Caroline, Soleti, Raffaella, Iacobazzi, Francesco, Simard, Gilles, Andriantsitohaina, Ramaroson

“…Red wine polyphenolic compounds (RWPC) are reported to exert vasculoprotective properties on endothelial cells, involving nitric oxide (NO) release via a…”
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Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis by Lange, Clemens, Mowat, Freya, Sayed, Haroon, Mehad, Manjit, Duluc, Lucie, Piper, Sophie, Luhmann, Ulrich, Nandi, Manasi, Kelly, Peter, Smith, Alexander, Ali, Robin, Leiper, James, Bainbridge, James

“…Ischemia-induced angiogenesis is critical for tissue repair, but aberrant neovascularization in the retina causes severe sight impairment. Nitric oxide (NO)…”
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Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction by Agouni, Abdelali, Tual-Chalot, Simon, Chalopin, Matthieu, Duluc, Lucie, Mody, Nimesh, Martinez, M. Carmen, Andriantsitohaina, Ramaroson, Delibegović, Mirela

“…Growing evidence suggests that hepatic-insulin resistance is sufficient to promote progression to cardiovascular disease. We have shown previously that…”
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Tipifarnib prevents development of hypoxia-induced pulmonary hypertension by Duluc, Lucie, Ahmetaj-Shala, Blerina, Mitchell, Jane, Abdul-Salam, Vahitha B, Mahomed, Abdul S, Aldabbous, Lulwah, Oliver, Eduardo, Iannone, Lucio, Dubois, Olivier D, Storck, Elisabeth M, Tate, Edward W, Zhao, Lan, Wilkins, Martin R, Wojciak-Stothard, Beata

“…RhoB plays a key role in the pathogenesis of hypoxia-induced pulmonary hypertension. Farnesylated RhoB promotes growth responses in cancer cells and we…”
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Estrogen Receptor α Participates to the Beneficial Effect of Red Wine Polyphenols in a Mouse Model of Obesity-Related Disorders by Leonetti, Daniela, Soleti, Raffaella, Clere, Nicolas, Vergori, Luisa, Jacques, Caroline, Duluc, Lucie, Dourguia, Catherine, Martínez, Maria C, Andriantsitohaina, Ramaroson

“…Red wine polyphenol extracts (polyphenols) ameliorate cardiovascular and metabolic disorders associated with obesity. Previously, we demonstrated that the…”
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Abstract 202: The Role of Neutrophil Extracellular Traps in the Pathogenesis of Pulmonary Hypertension by Aldabbous, Lulwah, Duluc, Lucie, McKinnon, Thomas, Howard, Luke, Gibbs, Simon, Wharton, John, Morrell, Nicholas, Toshner, Mark, Southwood, Mark, Pepke-Zaba, Joanna, Abdul-Salam, Vahitha, Wilkins, Martin, Wojciak-Stothard, Beata

“…Abstract only Rationale: Inflammation contributes to vasoconstriction and remodeling in pulmonary hypertension (PH), but the mechanisms are not fully…”
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Abstract 230: Protein Farnesylation Inhibitor Tipifarnib Prevents Development of Chronic Hypoxia-induced Pulmonary Hypertension by Duluc, Lucie, Ahmetaj-Shala, Blerina, Mitchell, Jane, Abdul-Salam, Vahitha B, Edwards, Robert, Aldabbous, Lulwah, Iannone, Lucio, Dubois, Olivier D, Storck, Elisabeth M, Tate, Edward W, Zhao, Lan, Wilkins, Martin, Wojciak-Stothard, Beata

“…Abstract only Study objectives: Small GTPase RhoB contributes to pulmonary vascular remodelling in pulmonary hypertension. Farnesylation of RhoB augments cell…”
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Liver‐specific Deletion of Protein Tyrosine Phosphatase (PTP) 1B Improves Endothelial Dysfunction and Cardiovascular Alterations Associated with Obesity in mice by Agouni, Abdelali, Tual-Chalot, Simon, Duluc, Lucie, Martinez, Carmen Maria, Mody, Nimesh, Andriantsitohaina, Ramaroson, Delibegovic, Mirela

“…Abstract only Obesity is tightly associated with insulin resistance (IR) and endothelial dysfunction. It is suggested that hepatic IR is sufficient to promote…”
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Mitochondria as potential targets of flavonoids: focus on adipocytes and endothelial cells by Duluc, L, Soleti, R, Clere, N, Andriantsitohaina, R, Simard, G

“…Obesity is a major public health problem, resulting from an excess of energy storage and/or a default of energy expenditure leading to the increased occurrence…”
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Systems biology of antioxidants by Andriantsitohaina, Ramaroson, Duluc, Lucie, García-Rodríguez, Julio C, Gil-del Valle, Lizette, Guevara-Garcia, Mariela, Simard, Gilles, Soleti, Raffaella, Su, Ding-Feng, Velásquez-Pérez, Luis, Wilson, John X, Laher, Ismail

“…Understanding the role of oxidative injury will allow for therapy with agents that scavenge ROS (reactive oxygen species) and antioxidants in the management of…”
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