Search Results - "Dulla, Chris G"

Glutamate Clearance Is Locally Modulated by Presynaptic Neuronal Activity in the Cerebral Cortex by Armbruster, Moritz, Hanson, Elizabeth, Dulla, Chris G

“…Excitatory amino acid transporters (EAATs) are abundantly expressed by astrocytes, rapidly remove glutamate from the extracellular environment, and restrict…”
Get full text

Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control by Cantu, David, Walker, Kendall, Andresen, Lauren, Taylor-Weiner, Amaro, Hampton, David, Tesco, Giuseppina, Dulla, Chris G

“…Traumatic brain injury (TBI) is a major risk factor for developing pharmaco-resistant epilepsy. Although disruptions in brain circuitry are associated with…”
Get full text

A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release by Tani, Hiroaki, Dulla, Chris G, Farzampour, Zoya, Taylor-Weiner, Amaro, Huguenard, John R, Reimer, Richard J

“…Biochemical studies suggest that excitatory neurons are metabolically coupled with astrocytes to generate glutamate for release. However, the extent to which…”
Get full text

Effects of fluorescent glutamate indicators on neurotransmitter diffusion and uptake by Armbruster, Moritz, Dulla, Chris G, Diamond, Jeffrey S

“…Genetically encoded fluorescent glutamate indicators (iGluSnFRs) enable neurotransmitter release and diffusion to be visualized in intact tissue. Synaptic…”
Get full text

Dysregulated Glucose Metabolism as a Therapeutic Target to Reduce Post-traumatic Epilepsy by Koenig, Jenny B, Dulla, Chris G

“…Traumatic brain injury (TBI) is a significant cause of disability worldwide and can lead to post-traumatic epilepsy. Multiple molecular, cellular, and network…”
Get full text

Neuronal Loss of the Glutamate Transporter GLT-1 Promotes Excitotoxic Injury in the Hippocampus by Rimmele, Theresa S, Li, Shaomin, Andersen, Jens Velde, Westi, Emil W, Rotenberg, Alexander, Wang, Jianlin, Aldana, Blanca Irene, Selkoe, Dennis J, Aoki, Chiye J, Dulla, Chris G, Rosenberg, Paul Allen

“…GLT-1, the major glutamate transporter in the mammalian central nervous system, is expressed in presynaptic terminals that use glutamate as a neurotransmitter,…”
Get full text

APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures by Pirone, Antonella, Alexander, Jon, Lau, Lauren A, Hampton, David, Zayachkivsky, Andrew, Yee, Amy, Yee, Audrey, Jacob, Michele H, Dulla, Chris G

“…Abstract Infantile spasms (IS) are a catastrophic childhood epilepsy syndrome characterized by flexion-extension spasms during infancy that progress to chronic…”
Get full text

Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK1‐WG4 report of the AES/ILAE Translational Task Force of the ILAE by Raimondo, Joseph V., Heinemann, Uwe, Curtis, Marco, Goodkin, Howard P., Dulla, Chris G., Janigro, Damir, Ikeda, Akio, Lin, Chou‐Ching K., Jiruska, Premysl, Galanopoulou, Aristea S., Bernard, Christophe

“…Summary In vitro preparations are a powerful tool to explore the mechanisms and processes underlying epileptogenesis and ictogenesis. In this review, we…”
Get full text

Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation by Andresen, Lauren, Hampton, David, Taylor-Weiner, Amaro, Morel, Lydie, Yang, Yongjie, Maguire, Jamie, Dulla, Chris G

“…Abstract Developmental cortical malformations are associated with a high incidence of drug-resistant epilepsy. The underlying epileptogenic mechanisms,…”
Get full text

Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust by Hanson, Elizabeth, Danbolt, Niels Christian, Dulla, Chris G

“…Abstract Developmental cortical malformations (DCMs) are linked with severe epilepsy and are caused by both genetic and environmental insults. DCMs include…”
Get full text

Kir4.1 channels contribute to astrocyte CO2/H+-sensitivity and the drive to breathe by Cleary, Colin M., Browning, Jack L., Armbruster, Moritz, Sobrinho, Cleyton R., Strain, Monica L., Jahanbani, Sarvin, Soto-Perez, Jaseph, Hawkins, Virginia E., Dulla, Chris G., Olsen, Michelle L., Mulkey, Daniel K.

“…Astrocytes in the retrotrapezoid nucleus (RTN) stimulate breathing in response to CO 2 /H + , however, it is not clear how these cells detect changes in CO 2…”
Get full text

Social Stimulus Causes Aberrant Activation of the Medial Prefrontal Cortex in a Mouse Model With Autism-Like Behaviors by Pirone, Antonella, Alexander, Jonathan M, Koenig, Jenny B, Cook-Snyder, Denise R, Palnati, Medha, Wickham, Robert J, Eden, Lillian, Shrestha, Neha, Reijmers, Leon, Biederer, Thomas, Miczek, Klaus A, Dulla, Chris G, Jacob, Michele H

“…Autism spectrum disorder (ASD) is a highly prevalent and genetically heterogeneous brain disorder. Developing effective therapeutic interventions requires…”
Get full text

Novel Approaches to Prevent Epileptogenesis After Traumatic Brain Injury by Dulla, Chris G., Pitkänen, Asla

“…Traumatic brain injury (TBI) is defined as an alteration in brain function or other evidence of brain pathology caused by an external force. When epilepsy…”
Get full text

How do we use in vitro models to understand epileptiform and ictal activity? A report of the TASK1-WG4 group of the ILAE/AES Joint Translational Task Force by Dulla, Chris G, Janigro, Damir, Jiruska, Premysl, Raimondo, Joseph V, Ikeda, Akio, Lin, Chou-Ching K, Goodkin, Howard P, Galanopoulou, Aristea S, Bernard, Christophe, de Curtis, Marco

“…In vitro brain tissue preparations allow the convenient and affordable study of brain networks and have allowed us to garner molecular, cellular, and…”
Get full text

Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis by Ameroso, Dominique, Meng, Alice, Chen, Stella, Felsted, Jennifer, Dulla, Chris G., Rios, Maribel

“…Brain-derived neurotrophic factor (BDNF) is essential for maintaining energy and glucose balance within the central nervous system. Because the study of its…”
Get full text

The THIK and Thin of Microglia Dynamics by Shih, Jennifer, Dulla, Chris G.

“…Madry et al. (2018) show that the two-pore potassium channel THIK-1 is tonically active in microglia and promotes microglial ramification and surveillance of…”
Get full text

Tonic Activation of GluN2C/GluN2D-Containing NMDA Receptors by Ambient Glutamate Facilitates Cortical Interneuron Maturation by Hanson, Elizabeth, Armbruster, Moritz, Lau, Lauren A, Sommer, Mary E, Klaft, Zin-Juan, Swanger, Sharon A, Traynelis, Stephen F, Moss, Stephen J, Noubary, Farzad, Chadchankar, Jayashree, Dulla, Chris G

“…Developing cortical GABAergic interneurons rely on genetic programs, neuronal activity, and environmental cues to construct inhibitory circuits during early…”
Get full text

Neuronal activity drives pathway-specific depolarization of peripheral astrocyte processes by Armbruster, Moritz, Naskar, Saptarnab, Garcia, Jacqueline P., Sommer, Mary, Kim, Elliot, Adam, Yoav, Haydon, Philip G., Boyden, Edward S., Cohen, Adam E., Dulla, Chris G.

“…Astrocytes are glial cells that interact with neuronal synapses via their distal processes, where they remove glutamate and potassium (K + ) from the…”
Get full text

The adenosine A1 receptor agonist WAG 994 suppresses acute kainic acid-induced status epilepticus in vivo by Klaft, Zin-Juan, Duerrwald, Lina M., Gerevich, Zoltan, Dulla, Chris G.

“…Status epilepticus (SE) is a neurological emergency characterized by continuous seizure activity lasting longer than 5 min, often with no recovery between…”
Get full text

Utilizing Animal Models of Infantile Spasms by Dulla, Chris G.

“…Infantile spasms are a devastating epileptic encephalopathy characterized by early life spasms and later seizures. Clinical outcomes of infantile spasms are…”
Get full text