Search Results - "Dulken, Ben"

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging by Leeman, Dena S, Hebestreit, Katja, Ruetz, Tyson, Webb, Ashley E, McKay, Andrew, Pollina, Elizabeth A, Dulken, Ben W, Zhao, Xiaoai, Yeo, Robin W, Ho, Theodore T, Mahmoudi, Salah, Devarajan, Keerthana, Passegué, Emmanuelle, Rando, Thomas A, Frydman, Judith, Brunet, Anne

“…In the adult brain, the neural stem cell (NSC) pool comprises quiescent and activated populations with distinct roles. Transcriptomic analysis revealed that…”
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Single-Cell Transcriptomic Analysis Defines Heterogeneity and Transcriptional Dynamics in the Adult Neural Stem Cell Lineage by Dulken, Ben W., Leeman, Dena S., Boutet, Stéphane C., Hebestreit, Katja, Brunet, Anne

“…Neural stem cells (NSCs) in the adult mammalian brain serve as a reservoir for the generation of new neurons, oligodendrocytes, and astrocytes. Here, we use…”
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Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses by Benayoun, Bérénice A, Pollina, Elizabeth A, Singh, Param Priya, Mahmoudi, Salah, Harel, Itamar, Casey, Kerriann M, Dulken, Ben W, Kundaje, Anshul, Brunet, Anne

“…Aging is accompanied by the functional decline of tissues. However, a systematic study of epigenomic and transcriptomic changes across tissues during aging is…”
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PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity by Gordon, Sydney R., Maute, Roy L., Dulken, Ben W., Hutter, Gregor, George, Benson M., McCracken, Melissa N., Gupta, Rohit, Tsai, Jonathan M., Sinha, Rahul, Corey, Daniel, Ring, Aaron M., Connolly, Andrew J., Weissman, Irving L.

“…Mouse and human tumour-associated macrophages express PD-1, which increases with cancer stage and induces decreased phagocytosis by macrophages; by contrast,…”
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Single-cell analysis reveals T cell infiltration in old neurogenic niches by Dulken, Ben W., Buckley, Matthew T., Navarro Negredo, Paloma, Saligrama, Naresha, Cayrol, Romain, Leeman, Dena S., George, Benson M., Boutet, Stéphane C., Hebestreit, Katja, Pluvinage, John V., Wyss-Coray, Tony, Weissman, Irving L., Vogel, Hannes, Davis, Mark M., Brunet, Anne

“…The mammalian brain contains neurogenic niches that comprise neural stem cells and other cell types. Neurogenic niches become less functional with age, but how…”
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Crystalline Hepatopathy Associated With Bietti Crystalline Dystrophy: A Striking Manifestation of Disordered Fatty Acid Metabolism by Dulken, Ben W, Bahceci, Dorukhan, Leung, Loh-Shan, Mahajan, Vinit B, Choi, Won-Tak, Tan, Serena Y

“…Bietti crystalline dystrophy (BCD) is a rare heritable retinal disease characterized by crystal deposition primarily in the retina. It is associated with…”
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CHRNA6 RNA In Situ Hybridization Is a Useful Tool for the Diagnosis of Extraskeletal Myxoid Chondrosarcoma by Dulken, Ben W., Kingsley, Leandra, Zdravkovic, Sabrina, Cespedes, Oscar, Qian, Xiaohua, Suster, David I., Charville, Gregory W.

“…Extraskeletal myxoid chondrosarcoma (EMC) is an uncommon mesenchymal neoplasm characteristically composed of uniform-appearing round to spindle-shaped cells…”
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Same path, different beginnings by Dulken, Ben W., Brunet, Anne

“…An extensive single-cell transcriptomic collection of over 30,000 cells of the developing hippocampus shows that adult hippocampal neurogenesis follows the…”
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S100 Protein Expression in Primary and Metastatic Neuroendocrine Neoplasms: A Specific Marker of Pancreatic Origin by Pepper, Michael A., Dulken, Ben W., Wang, Yiwen, Zemek, Allison J., Martin, Brock A., Charu, Vivek, Longacre, Teri A.

“…Neuroendocrine neoplasms can arise in a wide variety of anatomic sites including the gastrointestinal tract, pancreas, and lung, among others. Here, we report…”
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Mesenchymal stem cell-derived extracellular vesicles for the treatment of acute rejection in pediatric and adult bowel transplant by Levitte, Steven, Zhang, Ke-You, Guevara-Tique, Alix A., Ganguly, Abantika, Dulken, Ben W., Nilkant, Riya, Rigmaiden, Martina, Kumari, Radhika, Khlifi, Khalil, Thakor, Avnesh S., Bonham, Clark A.

“…Mesenchymal stem cells are under investigation as a novel therapy to treat solid organ transplant rejection. However, significant hurdles have limited their…”
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Leiomyomatosis in an Infant With a SUFU Splice Site Variant: Case Report by Rao, Rameshwar R., Dulken, Ben W., Matalon, Dena R., Borensztein, Maia, McGuinness, Molly, Cizek, Stephanie M., Bruzoni, Matias, Tan, Serena Y., Kreimer, Sara

“…Heterozygous loss-of-function variants in the suppressor of fused protein gene ( SUFU ) can result in Gorlin syndrome, which is characterized by an increased…”
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Inflamed immune phenotype predicts favorable clinical outcomes of immune checkpoint inhibitor therapy across multiple cancer types by Shen, Jeanne, Choi, Yoon-La, Lee, Taebum, Kim, Hyojin, Chae, Young Kwang, Dulken, Ben W, Bogdan, Stephanie, Huang, Maggie, Fisher, George A, Park, Sehhoon, Lee, Se-Hoon, Hwang, Jun-Eul, Chung, Jin-Haeng, Kim, Leeseul, Song, Heon, Pereira, Sergio, Shin, Seunghwan, Lim, Yoojoo, Ahn, Chang Ho, Kim, Seulki, Oum, Chiyoon, Kim, Sukjun, Park, Gahee, Song, Sanghoon, Jung, Wonkyung, Kim, Seokhwi, Bang, Yung-Jue, Mok, Tony S K, Ali, Siraj M., Ock, Chan-Young

“…BackgroundThe inflamed immune phenotype (IIP), defined by enrichment of tumor-infiltrating lymphocytes (TILs) within intratumoral areas, is a promising…”
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P161: A genetics-first approach to identify novel variants of the calcium sensing receptor associated with autosomal dominant hypocalcemia type 1 by Chang, Jeremy, Soliai, Marcus, Barnhill, Connor, Smith, Lyndsay, Mathew, Arun, Apostolov, Alexander, Dulken, Ben, Petukhov, Aleksandr, Sridhar, Ananth, Gorvin, Caroline, Lange, Christoph, Altman, Russ, Adler, Scott, Roberts, Mary Scott, Fox, Jonathan, Ji, Sun-Gou

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Sir2 deletion prevents lifespan extension in 32 long‐lived mutants by Delaney, Joe R., Sutphin, George L., Dulken, Ben, Sim, Sylvia, Kim, Jin R., Robison, Brett, Schleit, Jennifer, Murakami, Christopher J., Carr, Daniel, An, Elroy H., Choi, Eunice, Chou, Annie, Fletcher, Marissa, Jelic, Monika, Liu, Bin, Lockshon, Daniel, Moller, Richard M., Pak, Diana N., Peng, Qi, Peng, Zhao J., Pham, Kim M., Sage, Michael, Solanky, Amrita, Steffen, Kristan K., Tsuchiya, Mitsuhiro, Tsuchiyama, Scott, Johnson, Simon, Raabe, Chris, Suh, Yousin, Zhou, Zhongjun, Liu, Xinguang, Kennedy, Brian K., Kaeberlein, Matt

“…Summary Activation of Sir2 orthologs is proposed to increase lifespan downstream of dietary restriction. Here, we describe an examination of the effect of 32…”
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Stem Cell Aging and Sex: Are We Missing Something? by Dulken, Ben, Brunet, Anne

“…Longevity differs between sexes, with females being longer-lived in most mammals, including humans. One hallmark of aging is the functional decline of stem…”
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Abstract 6183: Exploring the role of microenvironment context on diagnostic accuracy in tissue microarray core selection by Woicik, Addie, McCaw, Zachary R., Dulken, Ben, Probert, Christopher

“…Abstract Background: Tissue Microarrays (TMAs) stand to significantly improve the efficiency of multiplex spatial studies by including core samples taken from…”
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Leiomyomatosis in an Infant With a SUFU Splice Site Variant: Case Report by Rao, Rameshwar R., Dulken, Ben W., Matalon, Dena R., Borensztein, Maia, McGuinness, Molly, Cizek, Stephanie M., Bruzoni, Matias, Tan, Serena Y., Kreimer, Sara

“…Heterozygous loss-of-function variants in the suppressor of fused protein gene (SUFU) can result in Gorlin syndrome, which is characterized by an increased…”
Get full text

S100 Protein Expression in Primary and Metastatic Neuroendocrine Neoplasms: A Specific Marker of Pancreatic Origin by Pepper, Michael A, Dulken, Ben W, Wang, Yiwen, Zemek, Allison J, Martin, Brock A, Charu, Vivek, Longacre, Teri A

“…Neuroendocrine neoplasms can arise in a wide variety of anatomic sites including the gastrointestinal tract, pancreas, and lung, among others. Here, we report…”
Get full text