Search Results - "Duley, J A"

Deep sequencing of the 16S ribosomal RNA of the neonatal oral microbiome: a comparison of breast-fed and formula-fed infants by Al-Shehri, S. S., Sweeney, E. L., Cowley, D. M., Liley, H. G., Ranasinghe, P. D., Charles, B. G., Shaw, P. N., Vagenas, D., Duley, J. A., Knox, C. L.

“…In utero and upon delivery, neonates are exposed to a wide array of microorganisms from various sources, including maternal bacteria. Prior studies have…”
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Low‐dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease by ANSARI, A., PATEL, N., SANDERSON, J., O’DONOHUE, J., DULEY, J. A., FLORIN, T. H. J.

“…Aliment Pharmacol Ther 31, 640–647 Summary Background  The thiopurine drugs, azathioprine and mercaptopurine (MP), are established treatments for IBD. However,…”
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Collection and determination of nucleotide metabolites in neonatal and adult saliva by high performance liquid chromatography with tandem mass spectrometry by Al-Shehri, S., Henman, M., Charles, B.G., Cowley, D., Shaw, P.N., Liley, H., Tomarchio, A., Punyadeera, C., Duley, J.A.

“…Saliva contains a number of biochemical components which may be useful for diagnosis/monitoring of metabolic disorders, and as markers of cancer or heart…”
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Erythrocyte thiopurine methyl transferase assessment prior to azathioprine use in the UK by Holme, S.A., Duley, J.A., Sanderson, J., Routledge, P.A., Anstey, A.V.

“…Background: Individuals with low activity of a key metabolic enzyme, thiopurine methyl transferase (TPMT), are more susceptible to azathioprine‐induced…”
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Observations on the use of allopurinol in combination with azathioprine or mercaptopurine by Duley, J. A., Chocair, P. R., Florin, T. H. J.

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Colonic microbiota can promote rapid local improvement of murine colitis by thioguanine independently of T lymphocytes and host metabolism by Oancea, I, Movva, R, Das, I, Aguirre de Cárcer, D, Schreiber, V, Yang, Y, Purdon, A, Harrington, B, Proctor, M, Wang, R, Sheng, Y, Lobb, M, Lourie, R, Ó Cuív, P, Duley, J A, Begun, J, Florin, T H J

“…Mercaptopurine (MP) and pro-drug azathioprine are 'first-line' oral therapies for maintaining remission in IBD. It is believed that their pharmacodynamic…”
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The effect of breastmilk and saliva combinations on the in vitro growth of oral pathogenic and commensal microorganisms by Sweeney, E. L., Al-Shehri, S. S., Cowley, D. M., Liley, H. G., Bansal, N., Charles, B. G., Shaw, P. N., Duley, J. A., Knox, C. L.

“…Neonates are exposed to microbes in utero and at birth, thereby establishing their microbiota (healthy microbial colonisers). Previously, we reported…”
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Do ITPA and TPMT genotypes predict the development of side effects to AZA? by Duley, J A, Marinaki, A M, Arenas, M, Florin, T H J

“…[...]we found an undigested band in this PCR which involved restriction endonuclease digestion that relies on creation of an Acc1 recognition site with an…”
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Mutation in the ITPA Gene Predicts Intolerance to Azathioprine by Marinaki, A. M., Duley, J. A., Arenas, M., Ansari, A., Sumi, S., Lewis, C. M., Shobowale-Bakre, M., Fairbanks, L. D., Sanderson, J.

“…Inosine triphosphate pyrophosphatase (ITPase) deficiency occurs with polymorphic frequencies in Caucasians and results in the benign accumulation of the…”
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Deoxyuridine accumulation in urine in thymidine phosphorylase deficiency (MNGIE) by Fairbanks, L. D., Marinaki, A. M., Carrey, E. A., Hammans, S. R., Duley, J. A.

“…We report the presence of the unusual nucleoside deoxyuridine in the urine of a patient with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) (MIM…”
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Pitfalls in the determination of mutant alleles of the thiopurine methyltransferase gene by Brouwer, C, Marinaki, A M, Lambooy, L H, Duley, J A, Shobowale-Bakre, M, De Abreu, R A

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When to investigate for purine and pyrimidine disorders. Introduction and review of clinical and laboratory indications by Simmonds, H. A., Duley, J. A., Fairbanks, L. D., McBride, M. B.

“…When to suspect and thus investigate for inborn errors of purine and pyrimidine metabolism is a dilemma for even the most observant investigator. Often parents…”
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Abnormalities in cellular adhesion of neuroblastoma and fibroblast models of Lesch Nyhan syndrome by Stacey, N.C, Ma, M.H.Y, Duley, J.A, Connolly, G.P

“…Lesch Nyhan syndrome is a neurological paediatric condition characterized by mental retardation, choreathotosis and self-mutilation. Biochemically, this…”
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The allopurinol load test lacks specificity for primary urea cycle defects but may indicate unrecognized mitochondrial disease by Bonham, J. R., Guthrie, P., Downing, M., Allen, J. C., Tanner, M. S., Sharrard, M., Rittey, C., Land, J. M., Fensom, A., O'Neill, D., Duley, J. A., Fairbanks, L. D.

“…Thirty‐three children ranging from 2 weeks to 12 years of age were selected for allopurinol loading, 16 on the basis of an increased urinary orotate excretion…”
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The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients by Chocair, P R, Duley, J A, Simmonds, H A, Cameron, J S

“…The immunosuppressive efficacy of azathioprine is related to its rapid metabolism in vivo to 6-mercaptopurine (6MP), with subsequent conversion to thioguanine…”
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Allele Frequency of Inosine Triphosphate Pyrophosphatase Gene Polymorphisms in a Japanese Population by Marinaki, A. M., Sumi, S., Arenas, M., Fairbanks, L., Harihara, S., Shimizu, K., Ueta, A., Duley, J. A.

“…The enzyme inosine triphosphate pyrophosphatase (ITPase) catalyses the pyrophosphohydrolysis of ITP to IMP. ITPase deficiency is a clinically benign autosomal…”
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Demonstration of induction of erythrocyte inosine monophosphate dehydrogenase activity in Ribavirin-treated patients using a high performance liquid chromatography linked method by Montero, C., Duley, J.A., Fairbanks, L.D., McBride, M.B., Micheli, V., Cant, A.J., Morgan, G.

“…The activity of inosine monophosphate dehydrogenase (IMPDH: EC 1.2.1.14) was measured in erythrocyte lysates using a non-radiolabelled method linked to…”
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Genetic Determinants of the Pre- and Post-Azathioprine Therapy Thiopurine Methyltransferase Activity Phenotype by Arenas, M., Duley, J. A., Ansari, A., Shobowale-Bakre, E. A., Fairbanks, L., Soon, S. Y., Sanderson, J., Marinaki, A. M.

“…Thiopurine drug therapy has been reported to lead to a variable increase in red cell TPMT activity that may alter effective dose and therapeutic outcome. The…”
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Pilot performance and preference for short cycles of automation in adaptive function allocation by Scallen, S.F., Hancock, P.A., Duley, J.A.

“…The present experiment examined pilot response to the rapid cycling of automation. The experiment was conducted using a multi-task simulation environment…”
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Ecto-nucleotidase of cultured rat superior cervical ganglia: dipyridamole is a novel inhibitor by Connolly, Gerald P, Duley, John A

“…Based on studies of agonist potencies on intact rat superior cervical ganglia, it has been suggested that this ganglion possesses distinct receptors for purine…”
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