Interrelationship between the chain length of poly-L-lysine and the degree of protection of polyribonucleotide interferon inducers from human blood nucleases

Interrelationship between the chain length of poly-L-lysine and the degree of protection of polyribonucleotide interferon inducers from human blood nucleases

The action of the human total blood serum on polynucleotide interferon inducers, larifan and ridostin (natural double-stranded RNAs) and poly(I).poly(C) (a double-stranded complex of synthetic polyribonucleotides) used both in the free state and in the state shielded with poly-L-lysine was studied....

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Bibliographic Details
Published in:Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 38; no. 7; p. 21
Main Authors: Surzhik, M A, Duks, A E, Diatlova, N G, Glazunov, E A, Feldmane, G Ia, Timkovskiĭ, A L
Format: Journal Article
Language:Russian
Published: Russia (Federation) 01-07-1993
Subjects:
Humans
Interferon Inducers - chemistry
Interferon Inducers - pharmacology
Kinetics
Molecular Weight
Organic Chemicals
Polylysine - chemistry
Ribonucleases - blood
RNA, Double-Stranded - chemistry
RNA, Double-Stranded - pharmacology
RNA, Fungal - chemistry
RNA, Fungal - pharmacology
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Summary:The action of the human total blood serum on polynucleotide interferon inducers, larifan and ridostin (natural double-stranded RNAs) and poly(I).poly(C) (a double-stranded complex of synthetic polyribonucleotides) used both in the free state and in the state shielded with poly-L-lysine was studied. The rate of the accumulation of the acid soluble products was compared with the residual interferon-inducing activity in mice. All the unshielded inducers were shown to completely loose their activity after a 4-hour contact with the serum. The protective activity of poly-L-lysine increased in parallel with the increase of its molecular weight and was maximal for the preparation with the molecular weight of 12300 +/- 1000 Da. Differences in the structure of the inducers and the mechanism of their biosynthesis and degradation must be taken into account.
ISSN:0235-2990