Search Results - "Dukes, Meghan W"

Modulation of Hedgehog Signaling for the Treatment of Basal Cell Carcinoma and the Development of Preclinical Models by Dukes, Meghan W, Meade, Thomas J

“…Basal Cell Carcinoma (BCC) is the most commonly diagnosed cancer worldwide. While the survivability of BCC is high, many patients are excluded from clinically…”
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Steering CAR T cell epigenetic programs by tweaking manufacturing protocol by Dukes, Meghan W., Krenciute, Giedre

“…CAR T cell persistence remains a significant roadblock to effective clinical translation of CAR T cells for solid and brain tumors. Jung et al.1 demonstrate…”
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Functional Disruption of Gli1‐DNA Recognition via a Cobalt(III) Complex by Brue, Christopher R., Dukes, Meghan W., Masotti, Meghan, Holmgren, Robert, Meade, Thomas J.

“…The aberrant activation of the Gli family of zinc finger transcription factors (ZFTFs) is associated with several types of human cancer, including…”
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Delivery of Targeted Co(III)–DNA Inhibitors of Gli Proteins to Disrupt Hedgehog Signaling by Dukes, Meghan W, Bajema, Elizabeth A, Whittemore, Tyler J, Holmgren, Robert A, Meade, Thomas J

“…The Hedgehog (Hh) signaling pathway is integral for embryonic development and normal cell maintenance. However, aberrant expression of the Hh pathway is…”
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Diquinol Functionality Boosts the Superoxide Dismutase Mimicry of a Zn(II) Complex with a Redox-Active Ligand while Maintaining Catalyst Stability and Enhanced Activity in Phosphate Solution by Moore, Jamonica L., Oppelt, Julian, Senft, Laura, Franke, Alicja, Scheitler, Andreas, Dukes, Meghan W., Alix, Haley B., Saunders, Alexander C., Karbalaei, Sana, Schwartz, Dean D., Ivanović-Burmazović, Ivana, Goldsmith, Christian R.

“…In the current work, we demonstrate ligand design concepts that significantly improve the superoxide dismutase (SOD) activity of a zinc complex; the catalysis…”
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289 Defining the T cell functional attributes of effective CAR T cell donors by Meehl, Michaela, Dukes, Meghan W, Krenciute, Giedre

“…BackgroundChimeric antigen receptor (CAR) T cell therapies have been used to effectively treat several hematological malignancies, resulting in six FDA…”
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Development of Delivery Vehicles and 3-Dimensional Cancer Models to Investigate Gli Inhibition in Basal Cell Carcinoma by Dukes, Meghan W

“…The worldwide community of patients affected by Basal Cell Carcinoma of the skin (BCC) is larger than that of any other cancer. While BCC is rarely lethal,…”
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250 Manipulating T cell epigenetic programs to improve persistence against group 3 pediatric medulloblastoma by Dukes, Meghan W, Senaoui, Linda, Houke, Haley, Zindy, Frederique, Youngblood, Benjamin, Roussel, Martine, Krenciute, Giedre

“…BackgroundSafe, effective therapies are desperately needed to improve survival and long-term quality of life for patients with medulloblastoma (MB), a…”
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