Search Results - "Duker, Nahum J"

Enzymic removal of 5-methylcytosine from DNA by a human DNA-glycosylase by Vairapandi, Mariappan, Duker, Nahum J.

“…DNA 5-methylcytosine is a major factor in the silencing of mammalian genes; it is involved in gene expression, differentiation, embryogenesis and neoplastic…”
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Identification of the cis-thymine glycol moiety in oxidized deoxyribonucleic acid by Frenkel, Krystyna, Goldstein, Mindy S, Duker, Nahum J, Teebor, George W

“…5,6-Dihydroxy-5,6-dihydrothymine (thymine glycol) is formed in DNA by reaction with oxidizing agents and as a result of ionizing and near-ultraviolet…”
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amyloid protein induces the formation of purine dimers in cellular DNA by Duker, Nahum J., Sperling, Joseph, Soprano, Kenneth J., Druin, Donald P., Davis, Andrea, Ashworth, Ren

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Chromosome breakage syndromes and cancer by Duker, Nahum J.

“…There exist numerous genetic disorders, marked by chromosome instability, that are strikingly associated with various cancers. Both the chromosomal…”
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Ultraviolet-induced thymine hydrates in DNA are excised by bacterial and human DNA glycosylase activities by Ganguly, Tapan, Weems, Kim M, Duker, Nahum J

“…Ultraviolet irradiation of DNA results in various pyrimidine modifications. We studied the excision of an ultraviolet thymine photoproduct by Escherichia coli…”
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Purine photoproducts by Duker, N J, Gallagher, P E

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Cytosine photoproduct-DNA glycosylase in Escherichia coli and cultured human cells by Weiss, Randi B, Gallagher, Patricia E, Brent, Thomas P, Duker, Nahum J

“…Ultraviolet irradiation of DNA produces a variety of pyrimidine base damages. The activities of Escherichia coli endonuclease III and a human lymphoblast…”
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Inhibition of enzymic incision of thymine dimers by covalently bound 2-[N-[(deoxyguanosin-8-yl)acetyl]amino]fluorene in deoxyribonucleic acid by Duker, Nahum J, Merkel, George W

“…The effects of DNA adducts of the carcinogen 2-[N-(acetoxyacetyl)amino]fluorene on enzymic incision of thymine dimers was investigated. Escherichia coli DNA…”
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Human endonuclease activity for DNA apurinic sites by TEEBOR, GEORGE W, DUKER, NAHUM J

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Perturbations of enzymic uracil excision due to guanine modifications in DNA by DUKER, N. J, HART, D. M

“…Phage PBS2 DNA, which contains uracil in place of thymine, was used as substrate for purified Bacillus subtilis uracil:DNA glycosylase. Incubation of this DNA…”
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Enzymic detection of uracil in a cloned and sequenced deoxyribonucleic acid segment by Weiss, Randi B, Mineura, Katsuyoshi, Henderson, Earl E, Duker, Nahum J, DeRiel, Jon Kimball

“…Uracil can occur in DNA either as a result of utilization of dUTP by DNA polymerases or from in situ deamination of cytosine. The latter results in transition…”
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Different ultraviolet DNA endonuclease activity in human cells by DUKER, NAHUM J, TEEBOR, GEORGE W

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Human DNA-demethylating activity: A glycosylase associated with RNA and PCNA by Vairapandi, Mariappan, Liebermann, Dan A., Hoffman, Barbara, Duker, Nahum J.

“…We have partially purified and characterized the 5‐methylcytosine removing activity (5‐meC‐DNA Glycosylase) from HeLa cells with 700‐fold enrichment. This…”
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β-amyloid protein induces the formation of purine dimers in cellular DNA by Duker, Nahum J., Sperling, Joseph, Soprano, Kenneth J., Druin, Donald P., Davis, Andrea, Ashworth, René

“…Experimental evidence implicates oxidative free radical reactions as central in the processes of neurodegenerative diseases. In particular, cellular…”
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Partial purification and characterization of human 5-methylcytosine-DNA glycosylase by Vairapandi, M, Duker, N J

“…The molecular mechanisms by which DNA 5-methylcytosine content is modulated are incompletely understood. Reduction of DNA 5-methylcytosine content has been…”
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Gaza by Gerber, Roger A, Reggev, Avner, Hornik, P. David, Zweibon, Herbert, Duker, Nahum J, Kaufman, Jerome S, Greenblatt, Matis, Streiter, Aaron, Gulko, David, Halkin, Hillel

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Stability of DNA thymine hydrates by GANGULY, T, DUKER, N. J

“…Pyrimidine hydrates are products of ultraviolet irradiation of DNA. We have already demonstrated the formation of both cis-thymine hydrate and trans-thymine…”
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Formation of purine photoproducts in a defined human DNA sequence by Gallagher, P E, Duker, N J

“…The formation of DNA base damages by broad spectrum ultraviolet irradiation (250-400 nm) was investigated using a defined sequence of human DNA. The…”
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Rates of heat-induced pyrimidine alterations in synthetic polydeoxyribonucleotides by Duker, N J

“…Hydrolytic damages to DNA can occur at physiological conditions. The possible role of DNA conformation on the distribution of such alterations of pyrimidines…”
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Endonucleolytic incision of UVB-irradiated DNA by Weiss, R B, Duker, N J

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