Search Results - "Duke, Charles B."

Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer by Ponnusamy, Suriyan, Coss, Christopher C, Thiyagarajan, Thirumagal, Watts, Kate, Hwang, Dong-Jin, He, Yali, Selth, Luke A, McEwan, Iain J, Duke, Charles B, Pagadala, Jayaprakash, Singh, Geetika, Wake, Robert W, Ledbetter, Christopher, Tilley, Wayne D, Moldoveanu, Tudor, Dalton, James T, Miller, Duane D, Narayanan, Ramesh

“…Androgen receptor (AR) mediates the growth of prostate cancer throughout its course of development, including in abnormal splice variants (AR-SV)-driven…”
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Micellar Delivery of Bicalutamide and Embelin for Treating Prostate Cancer by Danquah, Michael, Li, Feng, Duke, Charles B. III, Miller, Duane D, Mahato, Ram I

“…Purpose To examine the effect of bicalutamide and embelin on the growth of prostate cancer cells in vitro and in vivo Methods Cell viability was determined by…”
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Combination Therapy of Antiandrogen and XIAP Inhibitor for Treating Advanced Prostate Cancer by Danquah, Michael, Duke, Charles B., Patil, Renukadevi, Miller, Duane D., Mahato, Ram I.

“…ABSTRACT Purpose Overexpression of the androgen receptor (AR) and anti-apoptotic genes including X-linked inhibitor of apoptosis protein (XIAP) provide tumors…”
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Semiconductor Surface Reconstruction:  The Structural Chemistry of Two-Dimensional Surface Compounds by Duke, Charles B

“…Duke provides an overview of the surface structures of the clean surfaces of tetrahedrally coordinated semiconductors. Five principles govern the formation and…”
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novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer by Ahn, Sunjoo, Hwang, Dong Jin, Barrett, Christina M, Yang, Jun, Duke, Charles B. III, Miller, Duane D, Dalton, James T

“…Purpose Microtubules are one of the most useful subcellular targets in chemotherapy. We identified a novel indole,…”
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Development of Ultrafast Photochromic Organometallics and Photoinduced Linkage Isomerization of Arene Chromium Carbonyl Derivatives by To, Tung T, Heilweil, Edwin J, Duke, Charles B, Ruddick, Kristie R, Webster, Charles Edwin, Burkey, Theodore J

“…We review recent studies of processes relevant to photoinduced linkage isomerization of organometallic systems with the goal of preparing organometallics with…”
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Nonsteroidal selective androgen receptor modulators enhance female sexual motivation by Jones, Amanda, Hwang, Dong Jin, Duke, 3rd, Charles B, He, Yali, Siddam, Anjaiah, Miller, Duane D, Dalton, James T

“…Women experience a decline in estrogen and androgen levels after natural or surgically induced menopause, effects that are associated with a loss of sexual…”
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I-387, a novel antimitotic indole, displays a potent in vitro and in vivo antitumor activity with less neurotoxicity by Ahn, Sunjoo, Duke, 3rd, Charles B, Barrett, Christina M, Hwang, Dong Jin, Li, Chien-Ming, Miller, Duane D, Dalton, James T

“…(3-(1H-indol-2-yl)phenyl)(3,4,5-trimethoxyphenyl)methanone (I-387) is a novel synthetic compound that inhibits tubulin action and exhibits potent antitumor…”
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Androgen receptor antagonists: a patent review (2008-2011) by Mohler, Michael L, Coss, Christopher C, Duke, 3rd, Charles B, Patil, Shivaputra A, Miller, Duane D, Dalton, James T

“…Androgen receptor (AR) antagonists are predominantly used as chemical castration to treat prostate cancer (i.e., in conjunction with androgen deprivation…”
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Biotransformation of a Novel Antimitotic Agent, I-387, by Mouse, Rat, Dog, Monkey, and Human Liver Microsomes and In Vivo Pharmacokinetics in Mice by AHN, Sunjoo, KEARBEY, Jeffrey D, LI, Chien-Ming, DUKE, Charles B, MILLER, Duane D, DALTON, James T

“…3-(1H-Indol-2-yl)phenyl)(3,4,5-trimethoxyphenyl)methanone (I-387) is a novel indole compound with antitubulin action and potent antitumor activity in various…”
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Linkage Isomerization as a Mechanism for Photochromic Materials: Cyclopentadienylmanganese Tricarbonyl Derivatives with Chelatable Functional Groups by To, Tung T, Duke III, Charles B, Junker, Christopher S, O’Brien, Casey M, Ross II, Charles R, Barnes, Craig E, Webster, Charles Edwin, Burkey, Theodore J

“…Two, bifunctional side-chain cyclopentadienylmanganese tricarbonyl complexes, 7 (pyridine and ketone side chain) and 14 (thioamide and pyridine side chain),…”
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Solvent and Structural Effects on Ultrafast Chelation Dynamics of Arene Chromium Tricarbonyl Sulfide Derivatives by To, Tung T., Heilweil, Edwin J., Duke, Charles B., Burkey, Theodore J.

“…The chelation dynamics of three new [Cr{η6-C6H5C(O)R}(CO)3] complexes, 1 [R = CH2(SCH3)], 2 [R = CH(SCH3)2], and 3 [R = C(SCH3)3], has been investigated on the…”
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Unexpected Binding Orientation of Bulky-B-Ring Anti-Androgens and Implications for Future Drug Targets by Duke, Charles B, Jones, Amanda, Bohl, Casey E, Dalton, James T, Miller, Duane D

“…Several new androgen receptor antagonists were synthesized and found to have varying activities across typically anti-androgen resistant mutants (Thr877 → Ala…”
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Hypertension and Acute Mountain Sickness in Himalayan Trekkers in Nepal: An Observational Cohort Study by Duke, Charles B., Sallade, T. Douglas, Starling, Jennifer, Pant, Sushil, Sheets, Alison, McElwee, Matthew K., Young, David S., Taylor, Richard Andrew, Keyes, Linda E.

“…A history of preexisting hypertension is common in people participating in mountain activities; however, the relationship between blood pressure (BP),…”
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Degenerate Pathways for Metallacycle Ring Inversions: A Common Phenomenon Consistent with the Principle of Microscopic Reversibility by Letterman, Roger G, Duke, Charles B, To, Tung T, Burkey, Theodore J, Webster, Charles Edwin

“…Competing degenerate pathways for ring inversion in organometallic complexes are proposed to be ubiquitous examples that adhere to the principle of microscopic…”
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Photochemistry of Chromium Arene Tricarbonyl Complexes with Tethered Pyridinyl and Propenyl Groups: Investigations of the Effect of Ring Size on Chelate Formation, Structure, and Linkage Isomerization by Duke, Charles B, Letterman, Roger G, Johnson, Jermaine O, Barr, James W, Hu, Songnan, Ross, Charles R, Webster, Charles Edwin, Burkey, Theodore J

“…Chromium arene tricarbonyl complexes with tethered pyridinyl groups [Cr{η6-C6H5(CH2) n (2-Py)}(CO)3] (4–6) (2-Py = 2-pyridinyl, n = 1–3, respectively) were…”
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The surface science of xerography by Duke, Charles B., Noolandi, Jaan, Thieret, Tracy

“…Over the past four decades xerography, the dry ink marking process developed by the photocopy industry, has grown from nothing into a $170 billion industry…”
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Tricarbonyl(2-methyl-2-η 6 -phenyl-1,3-dioxolane)chromium(0) by Duke, Charles B., Ross, Charles R., Burkey, Theodore J.

“…The structure of the title compound, [Cr(C10H12O2)(CO)3], is presented. The distorted piano-stool geometry features an off-center Cr(CO)3 fragment which…”
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LDP Lean Document Production--O.R.-Enhanced Productivity Improvements for the Printing Industry by Rai, Sudhendu, Duke, Charles B, Lowe, Vaughn, Quan-Trotter, Cyndi, Scheermesser, Thomas

“…Xerox has invented, tested, and implemented a novel class of operations-research-based productivity-improvement offerings, trademarked LDP Lean Document…”
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Abstract 4548: Identify novel molecular structures targeting X-Linked Inhibitor of Apoptosis Protein by ligand-based virtual screening by Wang, Jin, Duke, Charles B., Li, Wei

“…Abstract Resistance to apoptosis is believed as one of the mechanism underlying a number of human malignancies notorious resistances to current…”
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