Search Results - "Dukanya, Dukanya"

Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase by Vishwanath, Divakar, Girimanchanaika, Swamy S, Dukanya, Dukanya, Rangappa, Shobith, Yang, Ji-Rui, Pandey, Vijay, Lobie, Peter E, Basappa, Basappa

“…Novel PARP inhibitors with selective mode-of-action have been approved for clinical use. Herein, oxadiazole based ligands that are predicted to target PARP-1…”
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Investigation of NPB Analogs That Target Phosphorylation of BAD-Ser99 in Human Mammary Carcinoma Cells by Girimanchanaika, Swamy Savvemala, Dukanya, Dukanya, Swamynayaka, Ananda, Govindachar, Divya Maldepalli, Madegowda, Mahendra, Periyasamy, Ganga, Rangappa, Kanchugarakoppal Subbegowda, Pandey, Vijay, Lobie, Peter E, Basappa, Basappa

“…The design and development of a small molecule named NPB [3-{(4(2,3-dichlorophenyl)piperazin-1-yl}{2-hydroxyphenyl)methyl}-N-cyclopentylbenzamide], which…”
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Oxazine drug-seed induces paraptosis and apoptosis through reactive oxygen species/JNK pathway in human breast cancer cells by Kim, Na Young, Dukanya, Dukanya, Sethi, Gautam, Girimanchanaika, Swamy S, Yang, Jirui, Nagaraja, Omantheswara, Swamynayaka, Ananda, Vishwanath, Divakar, Venkantesha, Keerthikumara, Basappa, Shreeja, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Madegowda, Mahendra, Sukhorukov, Alexey, Pandey, Vijay, Lobie, Peter E., Basappa, Basappa, Ahn, Kwang Seok

“…•To overcome drug-resistant breast cancer, it is essential to develop compounds that induce apoptosis and paraptosis.•BSO-07 triggered G1 phase arrest, cleaved…”
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Development of an Environment-Friendly and Electrochemical Method for the Synthesis of an Oxadiazole Drug-Scaffold That Targets Poly(ADP-Ribose)Polymerase in Human Breast Cancer Cells by Sindhu M. Parameshwaraiah, Zhang Xi, Akshay Ravish, Arunkumar Mohan, Vanishree Shankarnaik, Dukanya Dukanya, Shreeja Basappa, Habbanakuppe D. Preetham, Ganga Periyasamy, Santhosh L. Gaonkar, Peter E. Lobie, Vijay Pandey, Basappa Basappa

“…The development of environment-friendly new Poly-adenosine diphosphate (ADP)-ribose Polymerase (PARP) inhibitors are highly essential because of their…”
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Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer by Tan, Yan Qin, Chiou, Yi-Shiou, Guo, Hui, Zhang, Shuwei, Huang, Xiaoming, Dukanya, Dukanya, Kumar, Arun M., Basappa, Shreeja, Liu, Suling, Zhu, Tao, Basappa, Basappa, Pandey, Vijay, Lobie, Peter E.

“…Aberrant activation of the PI3K/AKT signaling axis along with the sustained phosphorylation of downstream BAD is associated with a poor outcome of TNBC…”
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Cyclization of Activated Methylene Isocyanides with Methyl N(N),N′-Di(tri)substituted Carbamimidothioate: A Novel Entry for the Synthesis of N,1-Aryl-4-tosyl/ethoxycarbonyl-1H-imidazol-5-amines by Dukanya, Dukanya, Swaroop, Toreshettahally R., Rangappa, Shobith, Rangappa, Kanchugarakoppal S., Basappa, Basappa

“…Abstract Base-induced cyclization of active methylene isocyanides with carbamimidothioates for the synthesis of N ,1-aryl-4-tosyl/ethylcarboxy-1 H…”
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Development of Novel Indazolyl‐Acyl Hydrazones as Antioxidant and Anticancer Agents that Target VEGFR‐2 in Human Breast Cancer Cells by Parameshwaraiah, Sindhu M., Shivakumar, Rashmi, Xi, Zhang, Siddappa, Tejaswini P., Ravish, Akshay, Mohan, Arunkumar, Poonacha, Lisha K., Uppar, Pradeep M., Basappa, Shreeja, Dukanya, Dukanya, Gaonkar, Santhosh L., Kemparaju, Kempaiah, Lobie, Peter E., Pandey, Vijay, Basappa, Basappa

“…The increased expression of VEGFR‐2 in a variety of cancer cells promotes a cascade of cellular responses that improve cell survival, growth, and…”
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Monomerization of Homodimeric Trefoil Factor 3 (TFF3) by an Aminonitrile Compound Inhibits TFF3-Dependent Cancer Cell Survival by Pandey, Vijay, Zhang, Xi, Poh, Han-Ming, Wang, Baocheng, Dukanya, Dukanya, Ma, Lan, Yin, Zhinan, Bender, Andreas, Periyasamy, Ganga, Zhu, Tao, Rangappa, Kanchugarakoppal S., Basappa, Basappa, Lobie, Peter E.

“…Trefoil factor 3 (TFF3) is a secreted protein with an established oncogenic function and a highly significant association with clinical progression of various…”
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Exploring the newer oxadiazoles as real inhibitors of human SIRT2 in hepatocellular cancer cells by Dukanya, Shanmugam, Muthu K., Rangappa, Shobith, Metri, Prashant K., Mohan, Surender, Basappa, Rangappa, Kanchugarakoppal S.

“…[Display omitted] A novel series of indazole tethered oxadiazoles (OTDs) derivatives were synthesized, characterized and screened for their anti-proliferative…”
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Synthesis and biological evaluation of theophylline acetohydrazide hydrazone derivatives as antituberculosis agents by Gopinatha, Vindya K., Dukanya, Mantelingu, Kempegowda, Rangappa, Kanchugarakoppal S.

“…A series of small molecules, theophylline acetohydrazide hydrazone derivatives were obtained via condensation of theophylline‐7‐acetohydrazide with different…”
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N-Substituted Pyrido-1,4-Oxazin-3-Ones Induce Apoptosis of Hepatocellular Carcinoma Cells by Targeting NF-κB Signaling Pathway by Mohan, Chakrabhavi Dhananjaya, Bharathkumar, Hanumantharayappa, Dukanya, Rangappa, Shobith, Shanmugam, Muthu K, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Alahmadi, Tahani Awad, Bhattacharjee, Atanu, Lobie, Peter E, Deivasigamani, Amudha, Hui, Kam Man, Sethi, Gautam, Basappa, Rangappa, Kanchugarakoppal S, Kumar, Alan Prem

“…Hepatocellular carcinoma (HCC) is a fatal disease and ranked fifth in cancer related mortality. Persistent activation of NF-κB is responsible for the…”
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Novel 1,3,4-oxadiazole Targets STAT3 Signaling to Induce Antitumor Effect in Lung Cancer by Malojirao, Vikas H, Girimanchanaika, Swamy S, Shanmugam, Muthu K, Sherapura, Ankith, Dukanya, Metri, Prashant K, Vigneshwaran, Vellingiri, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Rangappa, Shobith, Mohan, Chakrabhavi Dhananjaya, Basappa, Prabhakar, Bettadathunga T, Rangappa, Kanchugarakoppal S

“…Lung cancer is the leading type of malignancy in terms of occurrence and mortality in the global context. STAT3 is an oncogenic transcription factor that is…”
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Identification of a novel 1,2 oxazine that can induce apoptosis by targeting NF-κB in hepatocellular carcinoma cells by Somu, Chaithanya, Mohan, Chakrabhavi Dhananjaya, Ambekar, Sachin, Dukanya, Rangappa, Shobith, Baburajeev, CP, Sukhorukov, Alexey, Mishra, Srishti, Shanmugam, Muthu K, Chinnathambi, Arunachalam, Awad Alahmadi, Tahani, Alharbi, Sulaiman Ali, Basappa, Rangappa, Kanchugarakoppal S.

“…•10 new 1,2-Oxazines were synthesized and evaluated for their anticancer activity.•3i is lead cytotoxic agent which increased SubG1 cell population of HCC…”
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Anti-proliferative activity and characterization data on oxadiazole derivatives by Dukanya, Shanmugam, Muthu K, Rangappa, Shobith, Metri, Prashant K, Mohan, Surender, Basappa, Rangappa, Kanchugarakoppal S

“…This data in brief article explains the anti-cancer activity and characterization of oxadiazoles [1]. The main objective of this article was to provide general…”
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