Search Results - "Duivenvoorde, Leonie M."

Interleukin‐17A Inhibition Diminishes Inflammation and New Bone Formation in Experimental Spondyloarthritis by Tok, Melissa N., Duivenvoorde, Leonie M., Kramer, Ina, Ingold, Peter, Pfister, Sabina, Roth, Lukas, Blijdorp, Iris C., Sande, Marleen G. H., Taurog, Joel D., Kolbinger, Frank, Baeten, Dominique L.

“…Objective It remains unclear if and how inflammation and new bone formation in spondyloarthritis (SpA) are coupled. We undertook this study to assess the…”
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Contribution of Type H Blood Vessels to Pathologic Osteogenesis and Inflammation in an Experimental Spondyloarthritis Model by Kaaij, Merlijn H., Hamburg, Jan Piet, Rooijen, Charlotte C. N., Grüneboom, Anika, Kan, Yik Y., Pots, Desiree, Schett, Georg, Ruijven, Leo J., Duivenvoorde, Leonie M., Huitema, Leonie F. A., Baeten, Dominique L. P., Tas, Sander W.

“…Objective Spondyloarthritis (SpA) is characterized by pathologic osteogenesis, inflammation, and extensive angiogenesis in axial and peripheral tissues…”
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APRIL Induces a Novel Subset of IgA + Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1 by Fehres, Cynthia M, van Uden, Nathalie O, Yeremenko, Nataliya G, Fernandez, Leticia, Franco Salinas, Gabriela, van Duivenvoorde, Leonie M, Huard, Bertrand, Morel, Jacques, Spits, Hergen, Hahne, Michael, Baeten, Dominique L P

“…Regulatory B cells (Bregs) are immunosuppressive cells that modulate immune responses through multiple mechanisms. The signals required for the differentiation…”
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The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling by van Tok, Melissa N, Na, Songqing, Lao, Christopher R, Alvi, Marina, Pots, Desirée, van de Sande, Marleen G H, Taurog, Joel D, Sedgwick, Jonathon D, Baeten, Dominique L, van Duivenvoorde, Leonie M

“…IL-17A is a central driver of spondyloarthritis (SpA), its production was originally proposed to be IL-23 dependent. Emerging preclinical and clinical evidence…”
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Dual Blockade of TNF and IL-17A Inhibits Inflammation and Structural Damage in a Rat Model of Spondyloarthritis by Hammoura, Ihsan, Fiechter, Renee H, Bryant, Shaughn H, Westmoreland, Susan, Kingsbury, Gillian, Waegell, Wendy, Tas, Sander W, Baeten, Dominique L, van de Sande, Marleen G H, van Tok, Melissa N, van Duivenvoorde, Leonie M

“…The tumor necrosis factor (TNF) and IL-23/IL-17 axes are the main therapeutic targets in spondyloarthritis. Despite the clinical efficacy of blocking either…”
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Impact of the B Cell Growth Factor APRIL on the Qualitative and Immunological Characteristics of Atherosclerotic Plaques by Bernelot Moens, Sophie J, van Leuven, Sander I, Zheng, Kang H, Havik, Stefan R, Versloot, Miranda V, van Duivenvoorde, Leonie M, Hahne, Michael, Stroes, Erik S G, Baeten, Dominique L, Hamers, Anouk A J

“…Studies on the role of B lymphocytes in atherosclerosis development, have yielded contradictory results. Whereas B lymphocyte-deficiency aggravates…”
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mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone Formation in vitro and in vivo by Chen, Sijia, van Tok, Melissa N, Knaup, Véronique L, Kraal, Lianne, Pots, Désiree, Bartels, Lina, Gravallese, Ellen M, Taurog, Joel D, van de Sande, Marleen, van Duivenvoorde, Leonie M, Baeten, Dominique L

“…Spondyloarthritis (SpA) is characterized by inflammation, articular bone erosions and pathologic new bone formation. Targeting TNFα or IL-17A with current…”
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Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats by Taurog, Joel D., Rival, Claudia, van Duivenvoorde, Leonie M., Satumtira, Nimman, Dorris, Martha L., Sun, Margaret, Shelton, John M., Richardson, James A., Hamra, F. Kent, Hammer, Robert E., Tung, Kenneth S. K.

“…Objective Male rats transgenic for HLA–B27 and human β2‐microglobulin (hβ2m) spontaneously develop epididymoorchitis (EO) preceding the development of…”
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Paradoxical Augmentation of Experimental Spondyloarthritis by RORC Inhibition in HLA-B27 Transgenic Rats by van Tok, Melissa N, Mandour, Mohamed, Wahle, Joseph, Labadia, Mark E, van de Sande, Marleen G H, Nabozny, Gerald, Baeten, Dominique L, van Duivenvoorde, Leonie M

“…IL-17A plays a major role in the pathogenesis of spondyloarthritis (SpA). Here we assessed the impact of inhibition of RAR related orphan receptor-γ (RORC),…”
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Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats by van Tok, Melissa N, Satumtira, Nimman, Dorris, Martha, Pots, Desirée, Slobodin, Gleb, van de Sande, Marleen G, Taurog, Joel D, Baeten, Dominique L, van Duivenvoorde, Leonie M

“…Spondyloarthritis (SpA) does not display the typical features of auto-immune disease. Despite the strong association with MHC class I, CD8 T cells are not…”
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Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice by Habets, Kim L.L., van Puijvelde, Gijs H.M., van Duivenvoorde, Leonie M., van Wanrooij, Eva J.A., de Vos, Paula, Tervaert, Jan-Willem Cohen, van Berkel, Theo J.C., Toes, Rene E.M., Kuiper, Johan

“…Aims Modification of lipoproteins plays an important role in the development of atherosclerosis. Oxidatively modified low-density lipoprotein (oxLDL) has a…”
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Vaccination with Plasmodium knowlesi AMA1 formulated in the novel adjuvant co-vaccine HT™ protects against blood-stage challenge in rhesus macaques by Mahdi Abdel Hamid, Muzamil, Remarque, Edmond J, van Duivenvoorde, Leonie M, van der Werff, Nicole, Walraven, Vanessa, Faber, Bart W, Kocken, Clemens H M, Thomas, Alan W

“…Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a leading blood stage vaccine candidate. Plasmodium knowlesi AMA1 (PkAMA1) was produced and…”
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Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis by van Tok, Melissa N, Yeremenko, Nataliya G, Teitsma, Christine A, Kream, Barbara E, Knaup, Véronique L, Lories, Rik J, Baeten, Dominique L, van Duivenvoorde, Leonie M

“…Insulin like growth factor (IGF)-I can act on a variety of cells involved in cartilage and bone repair, yet IGF-I has not been studied extensively in the…”
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Immunomodulatory Dendritic Cells Inhibit Th1 Responses and Arthritis via Different Mechanisms by van Duivenvoorde, Leonie M, Han, Wanda G. H, Bakker, Aleida M, Louis-Plence, Pascale, Charbonnier, Louis-Marie, Apparailly, Florence, van der Voort, Ellen I. H, Jorgensen, Christian, Huizinga, Tom W. J, Toes, Rene E. M

“…Dendritic cells (DCs) are professional APCs which have the unique ability to present both foreign and self-Ags to T cells and steer the outcome of immune…”
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Transmembrane TNF drives osteoproliferative joint inflammation reminiscent of human spondyloarthritis by Kaaij, Merlijn H, van Tok, Melissa N, Blijdorp, Iris C, Ambarus, Carmen A, Stock, Michael, Pots, Désiree, Knaup, Véronique L, Armaka, Marietta, Christodoulou-Vafeiadou, Eleni, van Melsen, Tessa K, Masdar, Huriatul, Eskes, Harry J P P, Yeremenko, Nataliya G, Kollias, George, Schett, Georg, Tas, Sander W, van Duivenvoorde, Leonie M, Baeten, Dominique L P

“…TNF plays a key role in immune-mediated inflammatory diseases including rheumatoid arthritis (RA) and spondyloarthritis (SpA). It remains incompletely…”
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Suppression of Plasmodium cynomolgi in Rhesus Macaques by Coinfection with Babesia microti by van Duivenvoorde, Leonie M, Voorberg-van der Wel, Annemarie, van der Werff, Nicole M, Braskamp, Gerco, Remarque, Edmond J, Kondova, Ivanela, Kocken, Clemens H.M, Thomas, Alan W

“…Both Plasmodium and Babesia species are intraerythrocytic protozoans that infect a wide range of hosts, including humans, and they elicit similar inflammatory…”
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Review: Animal Models as a Tool to Dissect Pivotal Pathways Driving Spondyloarthritis by Vieira‐Sousa, Elsa, van Duivenvoorde, Leonie M., Fonseca, João E., Lories, Rik J., Baeten, Dominique L.

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Overexpression of Transmembrane TNF Drives Development of Ectopic Lymphoid Structures in the Bone Marrow and B Cell Lineage Alterations in Experimental Spondyloarthritis by Kaaij, Merlijn H., Rip, Jasper, Jeucken, Kim C. M., Kan, Yik Y., van Rooijen, Charlotte C. N., Saris, Job, Pots, Desiree, Frey, Silke, Grootjans, Joep, Schett, Georg, van Duivenvoorde, Leonie M., Nolte, Martijn A., Hendriks, Rudi W., Corneth, Odilia B. J., van Hamburg, Jan Piet, Baeten, Dominique L. P., Tas, Sander W.

“…Abstract TNF is important in immune-mediated inflammatory diseases, including spondyloarthritis (SpA). Transgenic (tg) mice overexpressing transmembrane TNF…”
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The cartilage protein melanoma inhibitory activity contributes to inflammatory arthritis by Yeremenko, Nataliya, Härle, Peter, Cantaert, Tineke, van Tok, Melissa, van Duivenvoorde, Leonie M., Bosserhoff, Anja, Baeten, Dominique

“…Objective. Melanoma inhibitory activity (MIA) is a small chondrocyte-specific protein with unknown function. MIA knockout mice (MIA−/−) have a normal phenotype…”
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Immature Dendritic Cells Suppress Collagen-Induced Arthritis by In Vivo Expansion of CD49b+ Regulatory T Cells by Charbonnier, Louis-Marie, van Duivenvoorde, Leonie M, Apparailly, Florence, Cantos, Celine, Han, Wanda G. H, Noel, Daniele, Duperray, Christophe, Huizinga, Tom W. J, Toes, Rene E. M, Jorgensen, Christian, Louis-Plence, Pascale

“…Dendritic cells (DCs) are specialized APCs with an important role in the initiation and regulation of immune responses. Immature DCs (iDCs) reportedly mediate…”
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