Search Results - "Duits, Flora H."

Synaptic proteins in CSF as potential novel biomarkers for prognosis in prodromal Alzheimer's disease by Duits, Flora H, Brinkmalm, Gunnar, Teunissen, Charlotte E, Brinkmalm, Ann, Scheltens, Philip, Van der Flier, Wiesje M, Zetterberg, Henrik, Blennow, Kaj

“…We investigated whether a panel of 12 potential novel biomarkers consisting of proteins involved in synapse functioning and immunity would be able to…”
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Matrix Metalloproteinases in Alzheimer's Disease and Concurrent Cerebral Microbleeds by Duits, Flora H, Hernandez-Guillamon, Mar, Montaner, Joan, Goos, Jereon D C, Montañola, Alex, Wattjes, Mike P, Barkhof, Frederik, Scheltens, Philip, Teunissen, Charlotte E, van der Flier, Wiesje M

“…Matrix metalloproteinases (MMPs) are a family of enzymes able to degrade components of the extracellular matrix, which is important for normal blood-brain…”
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Four subgroups based on tau levels in Alzheimer's disease observed in two independent cohorts by Duits, Flora H, Wesenhagen, Kirsten E J, Ekblad, Laura, Wolters, Emma, Willemse, Eline A J, Scheltens, Philip, van der Flier, Wiesje M, Teunissen, Charlotte E, Visser, Pieter Jelle, Tijms, Betty M

“…As Alzheimer's disease (AD) pathology presents decades before dementia manifests, unbiased biomarker cut-points may more closely reflect presence of pathology…”
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Nutrients required for phospholipid synthesis are lower in blood and cerebrospinal fluid in mild cognitive impairment and Alzheimer's disease dementia by van Wijk, Nick, Slot, Rosalinde E.R, Duits, Flora H, Strik, Marieke, Biesheuvel, Egbert, Sijben, John W.C, Blankenstein, Marinus A, Bierau, Jörgen, van der Flier, Wiesje M, Scheltens, Philip, Teunissen, Charlotte E

“…Abstract Introduction Synaptic membrane formation depends on nutrients that fuel metabolic pathways for the synthesis of constituent phospholipids…”
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Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease by Kvartsberg, Hlin, Duits, Flora H, Ingelsson, Martin, Andreasen, Niels, Öhrfelt, Annika, Andersson, Kerstin, Brinkmalm, Gunnar, Lannfelt, Lars, Minthon, Lennart, Hansson, Oskar, Andreasson, Ulf, Teunissen, Charlotte E, Scheltens, Philip, Van der Flier, Wiesje M, Zetterberg, Henrik, Portelius, Erik, Blennow, Kaj

“…Abstract Introduction Synaptic dysfunction is an early event in Alzheimer's disease (AD) pathogenesis and directly related to cognitive impairment…”
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Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study by Duits, Flora H, Martinez-Lage, Pablo, Paquet, Claire, Engelborghs, Sebastiaan, Lleó, Alberto, Hausner, Lucrezia, Molinuevo, José L, Stomrud, Erik, Farotti, Lucia, Ramakers, Inez H.G.B, Tsolaki, Magda, Skarsgård, Constance, Åstrand, Ragnar, Wallin, Anders, Vyhnalek, Martin, Holmber-Clausen, Marie, Forlenza, Orestes V, Ghezzi, Laura, Ingelsson, Martin, Hoff, Erik I, Roks, Gerwin, de Mendonça, Alexandre, Papma, Janne M, Izagirre, Andrea, Taga, Mariko, Struyfs, Hanne, Alcolea, Daniel A, Frölich, Lutz, Balasa, Mircea, Minthon, Lennart, Twisk, Jos W.R, Persson, Staffan, Zetterberg, Henrik, van der Flier, Wiesje M, Teunissen, Charlotte E, Scheltens, Philip, Blennow, Kaj

“…Abstract Introduction Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors…”
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The cerebrospinal fluid “Alzheimer profile”: Easily said, but what does it mean? by Duits, Flora H, Teunissen, Charlotte E, Bouwman, Femke H, Visser, Pieter-Jelle, Mattsson, Niklas, Zetterberg, Henrik, Blennow, Kaj, Hansson, Oskar, Minthon, Lennart, Andreasen, Niels, Marcusson, Jan, Wallin, Anders, Rikkert, Marcel Olde, Tsolaki, Magda, Parnetti, Lucilla, Herukka, Sanna-Kaisa, Hampel, Harald, De Leon, Mony J, Schröder, Johannes, Aarsland, Dag, Blankenstein, Marinus A, Scheltens, Philip, van der Flier, Wiesje M

“…Abstract Background We aimed to identify the most useful definition of the “cerebrospinal fluid Alzheimer profile,” based on amyloid-ß1-42 (Aβ42 ), total tau,…”
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Trajectories of behavior and social cognition in behavioral variant frontotemporal dementia and primary psychiatric disorders: A call for better operationalization of socioemotional changes by Fieldhouse, Jay L. P., Engelen, Marie‐Paule E., Handgraaf, Dédé, Boer, Sterre C. M., van ’t Hooft, Jochum J., Schouws, Sigfried N. T. M., Grootheest, Daniël, Kerssens, Cora, Duits, Flora H., Harten, Argonde C., Oudega, Mardien L., Vijverberg, Everard G. B., Pijnenburg, Yolande A. L.

“…Background and purpose Behavioral variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPD), such as mood, psychotic, and autism spectrum…”
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Diagnostic impact of CSF biomarkers for Alzheimer's disease in a tertiary memory clinic by Duits, Flora H, Prins, Niels D, Lemstra, Afina W, Pijnenburg, Yolande A.L, Bouwman, Femke H, Teunissen, Charlotte E, Scheltens, Philip, van der Flier, Wiesje M

“…Abstract Background We aimed to assess the impact of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease on decision making and patient management in…”
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Decreased emotion recognition and reduced focus on facial hallmarks in behavioral variant frontotemporal dementia compared to primary psychiatric disorders and controls by Fieldhouse, Jay L. P., Singleton, Ellen H., Engelen, Marie‐Paule E., Hooft, Jochum J., Boer, Sterre C. M., Froeling, Violet E., Braun, Michelle, Oudega, Mardien L., Grootheest, Daniël, Kerssens, Cora, Duits, Flora H., Harten, Argonde C., Vijverberg, Everard G. B., Pijnenburg, Yolande A. L.

“…Background and purpose Early diagnosis of behavioral variant frontotemporal dementia (bvFTD) is challenging due to symptomatic overlap with primary psychiatric…”
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Correcting for the Absence of a Gold Standard Improves Diagnostic Accuracy of Biomarkers in Alzheimer's Disease by Coart, Els, Barrado, Leandro García, Duits, Flora H, Scheltens, Philip, van der Flier, Wiesje M, Teunissen, Charlotte E, van der Vies, Saskia M, Burzykowski, Tomasz

“…Studies investigating the diagnostic accuracy of biomarkers for Alzheimer's disease (AD) are typically performed using the clinical diagnosis or amyloid-β…”
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Increase in cerebrospinal fluid F2-isoprostanes is related to cognitive decline in APOE ε4 carriers by Duits, Flora H, Kester, Maartje I, Scheffer, Peter G, Blankenstein, Marinus A, Scheltens, Philip, Teunissen, Charlotte E, van der Flier, Wiesje M

“…In this longitudinal study we investigated the effect of apolipoprotein E (APOE) genotype on the relation between cognitive decline and cerebrospinal fluid…”
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CEREBROSPINAL FLUID NEUROGRANIN AS A PROGNOSTIC MARKER IN MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE by Duits, Flora H, Johansson-Schmidt, Hlin, Portelius, Erik, Andersson, Kerstin, Andreasson, Ulf, Teunissen, Charlotte, Scheltens, Philip, van der Flier, Wiesje M, Zetterberg, Henrik, Blennow, Kaj

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Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lp feasibility study by Duits, Flora H, Martinez-Lage, Pablo, Paquet, Claire, Engelborghs, Sebastiaan, Lleó, Alberto, Hausner, Lucrezia, Molinuevo, José L, Stomrud, Erik, Farotti, Lucia, Ramakers, Inez H.G.B, Tsolaki, Magda, Skarsgard, Constance, Astrand, Ragnar, Wallin, Anders, Vyhnalek, Martin, Holmber-Clausen, Marie, Forlenza, Orestes Vicente, Ingelsson, Martin, Hoff, Erik, Roks, Gerwin, de Mendonça, Alexandre, Papma, Janne, Izagirre, Andrea, Taga, Mariko, Struyfs, Hanne, Alcolea, Daniel Andres, Frölich, Lutz, Balasa, Mircea, Minthon, Lennart, Twisk, Jos W.R, Persson, Staffan, Zetterberg, Henrik, van der Flier, Wiesje M, Teunissen, Charlotte E, Scheltens, Philip, Blennow, Kaj

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Proteins involved in synapse organization are associated with longitudinal loss in gray matter network connectivity in prodromal AD by de Leeuw, Diederick Martijn, Duits, Flora H., Vromen, Eleonora M., Dicks, Ellen, Barkhof, Frederik, Visser, Pieter Jelle, Tijms, Betty M.

“…Background Lower gray matter connectivity measures are related to faster cognitive decline in prodromal Alzheimer’s Disease (AD). We investigated the…”
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Measuring synaptic loss in early AD stages: Trajectories of SNAP25 and SYT1 using serial CSF sampling by Duits, Flora H., Brinkmalm, Ann, Scheltens, Philip, Blennow, Kaj, Zetterberg, Henrik, van der Flier, Wiesje M., Teunissen, Charlotte E.

“…Background It is increasingly recognized that synaptic dysfunction plays an important role in Alzheimer pathology, already in an early phase. In this study we…”
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Synaptic dysfunction reflected in CSF: serial CSF sampling reveals trajectories of potential synaptic biomarkers in early AD stages by Duits, Flora H., Nilsson, Johanna, Teunissen, Charlotte E., Zetterberg, Henrik, Blennow, Kaj, Scheltens, Philip, van der Flier, Wiesje M., Brinkmalm, Ann

“…Background Synaptic dysfunction plays an important role in Alzheimer’s disease (AD) and cognitive decline. Using serial CSF sampling we investigated…”
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Consensus guidelines for lumbar puncture in patients with neurological diseases by Engelborghs, Sebastiaan, Niemantsverdriet, Ellis, Struyfs, Hanne, Blennow, Kaj, Brouns, Raf, Comabella, Manuel, Dujmovic, Irena, van der Flier, Wiesje, Frölich, Lutz, Galimberti, Daniela, Gnanapavan, Sharmilee, Hemmer, Bernhard, Hoff, Erik, Hort, Jakub, Iacobaeus, Ellen, Ingelsson, Martin, Jan de Jong, Frank, Jonsson, Michael, Khalil, Michael, Kuhle, Jens, Lleó, Alberto, de Mendonça, Alexandre, Molinuevo, José Luis, Nagels, Guy, Paquet, Claire, Parnetti, Lucilla, Roks, Gerwin, Rosa-Neto, Pedro, Scheltens, Philip, Skårsgard, Constance, Stomrud, Erik, Tumani, Hayrettin, Visser, Pieter Jelle, Wallin, Anders, Winblad, Bengt, Zetterberg, Henrik, Duits, Flora, Teunissen, Charlotte E

“…Abstract Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases…”
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P3‐264: UNBIASED METHOD TO DETERMINE CUT‐POINTS FOR CSF TOTAL TAU LEVELS REVEALS PRESENCE OF BIOLOGICAL SUBTYPES IN A LARGE ALZHEIMER'S DISEASE POPULATION by Duits, Flora H., Willemse, Eline A.J., Visser, Pieter Jelle, Barkhof, Frederik, Scheltens, Philip, Teunissen, Charlotte E., Flier, Wiesje M., Tijms, Betty M.

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UNBIASED METHOD TO DETERMINE CUT-POINTS FOR CSF TOTAL TAU LEVELS REVEALS PRESENCE OF BIOLOGICAL SUBTYPES IN A LARGE ALZHEIMER’S DISEASE POPULATION by Duits, Flora H., Willemse, Eline A.J., Visser, Pieter Jelle, Barkhof, Frederik, Scheltens, Philip, Teunissen, Charlotte E., Van der Flier, Wiesje M., Tijms, Betty M.

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