Search Results - "Duikeren, Suzanne"

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin by Qiao, Xiaohang, van der Zanden, Sabina Y., Wander, Dennis P. A., Borràs, Daniel M., Song, Ji-Ying, Li, Xiaoyang, van Duikeren, Suzanne, van Gils, Noortje, Rutten, Arjo, van Herwaarden, Tessa, van Tellingen, Olaf, Giacomelli, Elisa, Bellin, Milena, Orlova, Valeria, Tertoolen, Leon G. J., Gerhardt, Sophie, Akkermans, Jimmy J., Bakker, Jeroen M., Zuur, Charlotte L., Pang, Baoxu, Smits, Anke M., Mummery, Christine L., Smith, Linda, Arens, Ramon, Li, Junmin, Overkleeft, Hermen S., Neefjes, Jacques

“…The anthracycline doxorubicin (Doxo) and its analogs daunorubicin (Daun), epirubicin (Epi), and idarubicin (Ida) have been cornerstones of anticancer therapy…”
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Interleukin‐6‐mediated resistance to immunotherapy is linked to impaired myeloid cell function by Beyranvand Nejad, Elham, Labrie, Camilla, Sluis, Tetje C., Duikeren, Suzanne, Franken, Kees L. M. C., Roosenhoff, Rueshandra, Arens, Ramon, Hall, Thorbald, Burg, Sjoerd H.

“…High serum levels of interleukin‐6 (IL‐6) correlate with poor prognosis and chemotherapy resistance in several cancers. The underlying mechanisms and its…”
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The Breadth of Synthetic Long Peptide Vaccine-Induced CD8+ T Cell Responses Determines the Efficacy against Mouse Cytomegalovirus Infection by Panagioti, Eleni, Redeker, Anke, van Duikeren, Suzanne, Franken, Kees Lmc, Drijfhout, Jan Wouter, van der Burg, Sjoerd H, Arens, Ramon

“…There is an ultimate need for efficacious vaccines against human cytomegalovirus (HCMV), which causes severe morbidity and mortality among neonates and…”
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OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum by van der Sluis, Tetje C., Beyrend, Guillaume, van der Gracht, Esmé T.I., Abdelaal, Tamim, Jochems, Simon P., Belderbos, Robert A., Wesselink, Thomas H., van Duikeren, Suzanne, van Haften, Floortje J., Redeker, Anke, Ouboter, Laura F., Beyranvand Nejad, Elham, Camps, Marcel, Franken, Kees L.M.C., Linssen, Margot M., Hohenstein, Peter, de Miranda, Noel F.C.C., Mei, Hailiang, Bins, Adriaan D., Haanen, John B.A.G., Aerts, Joachim G., Ossendorp, Ferry, Arens, Ramon

“…Immune checkpoint therapy (ICT) has the power to eradicate cancer, but the mechanisms that determine effective therapy-induced immune responses are not fully…”
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A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control by Tondini, Elena, Arakelian, Tsolere, Oosterhuis, Koen, Camps, Marcel, van Duikeren, Suzanne, Han, Wanda, Arens, Ramon, Zondag, Gerben, van Bergen, Jeroen, Ossendorp, Ferry

“…The combination of immune-stimulating strategies has the potency to improve immunotherapy of cancer. Vaccination against neoepitopes derived from patient tumor…”
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Dominant Antiviral CD8 + T Cell Responses Empower Prophylactic Antibody-Eliciting Vaccines Against Cytomegalovirus by Pardieck, Iris N, van Duikeren, Suzanne, Veerkamp, Dominique M B, Brasem, Dena J, Redeker, Anke, van Bergen, Jeroen, Han, Wanda, Ossendorp, Ferry, Zondag, Gerben, Arens, Ramon

“…Human cytomegalovirus (HCMV) is an ubiquitous herpesvirus that can cause serious morbidity and mortality in immunocompromised or immune-immature individuals. A…”
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PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors by Beyrend, Guillaume, van der Gracht, Esmé, Yilmaz, Ayse, van Duikeren, Suzanne, Camps, Marcel, Höllt, Thomas, Vilanova, Anna, van Unen, Vincent, Koning, Frits, de Miranda, Noel F C C, Arens, Ramon, Ossendorp, Ferry

“…The clinical benefit of immunotherapeutic approaches against cancer has been well established although complete responses are only observed in a minority of…”
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Enhanced cross-presentation and improved CD8+ T cell responses after mannosylation of synthetic long peptides in mice by Rauen, Judith, Kreer, Christoph, Paillard, Arlette, van Duikeren, Suzanne, Benckhuijsen, Willemien E, Camps, Marcel G, Valentijn, A Rob P M, Ossendorp, Ferry, Drijfhout, Jan W, Arens, Ramon, Burgdorf, Sven

“…The use of synthetic long peptides (SLP) has been proven to be a promising approach to induce adaptive immune responses in vaccination strategies. Here, we…”
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Delayed vaccine-induced CD8+ T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication by van der Sluis, Tetje C, van Haften, Floortje J, van Duikeren, Suzanne, Pardieck, Iris N, de Graaf, J Fréderique, Vleeshouwers, Ward, van der Maaden, Koen, Melief, Cornelis J M, van der Burg, Sjoerd H, Arens, Ramon

“…BackgroundThe survival of patients with cervical cancer who are treated with cisplatin in conjunction with the topoisomerase I inhibitor topotecan is enhanced…”
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Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy by Beyranvand Nejad, Elham, Labrie, Camilla, Abdulrahman, Ziena, van Elsas, Marit J, Rademaker, Eva, Kleinovink, Jan Willem, van der Sluis, Tetje C, van Duikeren, Suzanne, Teunisse, Amina F A.S, Jochemsen, Aart G, Oosting, Jan, de Miranda, Noel F C C, Van Hall, Thorbald, Arens, Ramon, van der Burg, Sjoerd H

“…BackgroundImmunotherapy of cancer is successful but tumor regression often is incomplete and followed by escape. Understanding the mechanisms underlying this…”
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Adenoviral vaccines promote protective tissue-resident memory T cell populations against cancer by van der Gracht, Esmé TI, Schoonderwoerd, Mark JA, van Duikeren, Suzanne, Yilmaz, Ayse N, Behr, Felix M, Colston, Julia M, Lee, Lian N, Yagita, Hideo, van Gisbergen, Klaas PJM, Hawinkels, Lukas JAC, Koning, Frits, Klenerman, Paul, Arens, Ramon

“…BackgroundAdenoviral vectors emerged as important platforms for cancer immunotherapy. Vaccination with adenoviral vectors is promising in this respect,…”
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Memory CD8+ T cell heterogeneity is primarily driven by pathogen-specific cues and additionally shaped by the tissue environment by van der Gracht, Esmé T.I., Beyrend, Guillaume, Abdelaal, Tamim, Pardieck, Iris N., Wesselink, Thomas H., van Haften, Floortje J., van Duikeren, Suzanne, Koning, Frits, Arens, Ramon

“…Factors that govern the complex formation of memory T cells are not completely understood. A better understanding of the development of memory T cell…”
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CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses by Rosalia, Rodney A, Cruz, Luis J, van Duikeren, Suzanne, Tromp, Angelino T, Silva, Ana L, Jiskoot, Wim, de Gruijl, Tanja, Löwik, Clemens, Oostendorp, Jaap, van der Burg, Sjoerd H, Ossendorp, Ferry

“…Abstract Dendritic cells (DC) play a prominent role in the priming of CD8+ T cells. Vaccination is a promising treatment to boost tumor-specific CD8+ T cells…”
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Tumor Eradication by Cisplatin Is Sustained by CD80/86-Mediated Costimulation of CD8+ T Cells by Beyranvand Nejad, Elham, van der Sluis, Tetje C, van Duikeren, Suzanne, Yagita, Hideo, Janssen, George M, van Veelen, Peter A, Melief, Cornelis J M, van der Burg, Sjoerd H, Arens, Ramon

“…Certain cytotoxic chemotherapeutic drugs are immunogenic, stimulating tumor immunity through mechanisms that are not completely understood. Here we show how…”
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Vaccination during myeloid cell depletion by cancer chemotherapy fosters robust T cell responses by Welters, Marij J, van der Sluis, Tetje C, van Meir, Hélène, Loof, Nikki M, van Ham, Vanessa J, van Duikeren, Suzanne, Santegoets, Saskia J, Arens, Ramon, de Kam, Marieke L, Cohen, Adam F, van Poelgeest, Mariette I, Kenter, Gemma G, Kroep, Judith R, Burggraaf, Jacobus, Melief, Cornelis J, van der Burg, Sjoerd H

“…Therapeutic vaccination with human papillomavirus type 16 synthetic long peptides (HPV16-SLPs) results in T cell-mediated regression of HPV16-induced…”
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Synergy of therapeutic vaccination against HPV16 oncogenic proteins and standard chemotherapeutics by Melief, Cornelis J, Welters, Marij JP, van der Sluis, Tetje, van Meir, Helene, van Duikeren, Suzanne, Huppelschoten, Suzanna, Jordanova, Ekaterina S, Kroep, Judith, Kenter, Gemma, Smit, Vincent, Ossendorp, Ferry, van de Water, Bob, van Poelgeest, Mariette, Burggraaf, Jacobus, Arens, Ramon, van der Burg, Sjoerd H

“…We previously developed a synthetic long peptide (SLP) vaccine against HPV16 oncoproteins that induced lesion regression in patients with HPV16+ high-grade…”
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Inhibiting the NADase CD38 improves cytomegalovirus-specific [CD8.sup.+] T cell functionality and metabolism by Mulling, Nils, Behr, Felix M, Heieis, Graham A, Boss, Kristina, van Duikeren, Suzanne, van Haften, Floortje J, Pardieck, Iris N, van der Gracht, Esme T.I, Vleeshouwers, Ward, van der Sluis, Tetje C, de Graaf, J. Frederique, Veerkamp, Dominique M.B, Franken, Kees L.M.C, Lei, Xin, van de Sand, Lukas, van der Burg, Sjoerd H, Welters, Marij J.P, Heidt, Sebastiaan, Huisman, Wesley, Jochems, Simon P, Giera, Martin, Witzke, Oliver, de Vries, Aiko P.J, Kribben, Andreas, Everts, Bart, Wilde, Benjamin, Arens, Ramon

“…Cytomegalovirus (CMV) is one of the most common and relevant opportunistic pathogens in people who are immunocompromised, such as kidney transplant recipients…”
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Vaccine-induced effector-memory CD8+ T cell responses predict therapeutic efficacy against tumors by van Duikeren, Suzanne, Fransen, Marieke F, Redeker, Anke, Wieles, Brigitte, Platenburg, Gerard, Krebber, Willem-Jan, Ossendorp, Ferry, Melief, Cornelis J M, Arens, Ramon

“…CD8(+) T cells have the potential to attack and eradicate cancer cells. The efficacy of therapeutic vaccines against cancer, however, lacks defined immune…”
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Enhanced HPV16 E6/E7+ tumor eradication via induction of tumor-specific T cells by therapeutic vaccination with virosomes presenting synthetic long peptides by Stegmann, Toon, Wiekmeijer, Anna-Sophia, Kwappenberg, Kitty, van Duikeren, Suzanne, Bhoelan, Farien, Bemelman, Denzel, Beenakker, Thomas J. M., Krebber, Willem-Jan, Arens, Ramon, Melief, Cornelis J. M.

“…Therapeutic cancer vaccines trigger CD4 + and CD8 + T cell responses capable of established tumor eradication. Current platforms include DNA, mRNA and…”
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Inhibiting the NADase CD38 improves cytomegalovirus-specific CD8+ T cell functionality and metabolism by Mülling, Nils, Behr, Felix M, Heieis, Graham A, Boss, Kristina, Van duikeren, Suzanne, Van haften, Floortje J, Pardieck, Iris N, van der Gracht, Esmé T I, Vleeshouwers, Ward, van der Sluis, Tetje C, de Graaf, J Fréderique, Veerkamp, Dominique M B, Franken, Kees L M C, Lei, Xin, van de Sand, Lukas, van der burg, Sjoerd H, Welters, Marij J P, Heidt, Sebastiaan, Huisman, Wesley, Jochems, Simon P, Giera, Martin, Witzke, Oliver, de Vries, Aiko P J, Kribben, Andreas, Everts, Bart, Wilde, Benjamin, Arens, Ramon

“…Cytomegalovirus (CMV) is one of the most common and relevant opportunistic pathogens in people who are immunocompromised, such as kidney transplant recipients…”
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