Search Results - "Duignan, D B"

Understanding the clinical pharmacokinetics of a GABAA partial agonist by application of in vitro tools by Sawant, A.D., Miller, E.L., Duignan, D.B., Brodfuehrer, J., Winter, S.M., Nelson, F.R., Kamel, A., Obach, R.S., Vaz, A.D.N.

“…4-Oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (4-methylaminomethyl-phenyl)-amide (1), developed for general anxiety disorder, was discontinued from…”
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Selective inactivation by chloramphenicol of the major phenobarbital-inducible isozyme of dog liver cytochrome P-450 by Ciaccio, P J, Duignan, D B, Halpert, J R

“…Chloramphenicol (CAP) is a potent and effective mechanism-based inactivator of the major phenobarbital (PB)-inducible isozyme of dog liver cytochrome P-450…”
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Purification and characterization of the dog hepatic cytochrome P-450 isozyme responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl by Duignan, D B, Sipes, I G, Leonard, T B, Halpert, J R

“…The biochemical basis for the marked difference in the rate of the hepatic metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl (245-HCB) by Beagle dogs and…”
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The metabolism of xenobiotics and endogenous compounds by the constitutive dog liver cytochrome P450 PBD-2 by Duignan, D B, Sipes, I G, Ciaccio, P J, Halpert, J R

“…We have investigated the metabolism of polychlorinated biphenyls and endogenous steroids by the major phenobarbital (PB)-inducible hepatic cytochromes P450 in…”
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Synthesis, sar and pharmacology of CP-293,019 : A potent, selective dopamine D4 receptor antagonist by SANNER, M. A, CHAPPIE, T. A, MAJCHRZAK, M. J, FARACI, W. S, COLLINS, J. L, DUIGNAN, D. B, DI PRETE, C. C, LEE, J. S, TROZZI, A, DUNAISKIS, A. R, FLIRI, A. F, DESAI, K. A, ZORN, S. H, JACKSON, E. R, JOHNSON, C. G, MORRONE, J. M, SEYMOUR, P. A

“…A series of novel, potent and selective pyrido[1,2-a]pyrazine dopamine D4 receptor antagonists are reported including CP-293,019 (D4 Ki = 3.4 nM, D2 Ki > 3,310…”
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Expression and Characterization of Canine Cytochrome P450 2D15 by Roussel, Fabienne, Duignan, David B., Lawton, Michael P., Obach, R.Scott, Strick, Christine A., Tweedie, Donald J.

“…CYP2D15 is the canine ortholog of human CYP2D6, the human CYP2D isoform involved in the metabolism of drugs such as antiarhythmics, adrenoceptor antagonists,…”
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Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats by Harris, Christopher M, Mittelstadt, Scott, Banfor, Patricia, Bousquet, Peter, Duignan, David B, Gintant, Gary, Hart, Michelle, Kim, Youngjae, Segreti, Jason

“…Inhibition of the sphingosine-1-phosphate (S1P)-catabolizing enzyme S1P lyase (S1PL) elevates the native ligand of S1P receptors and provides an alternative…”
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Understanding the clinical pharmacokinetics of a GABA A partial agonist by application of in vitro tools by Sawant, A.D., Miller, E.L., Duignan, D.B., Brodfuehrer, J., Winter, S.M., Nelson, F.R., Kamel, A., Obach, R.S., Vaz, A.D.N.

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A 96-Well Efflux Assay To Identify ABCG2 Substrates Using a Stably Transfected MDCK II Cell Line by Xiao, Yongling, Davidson, Ralph, Smith, Arthur, Pereira, Dennis, Zhao, Sabrina, Soglia, John, Gebhard, David, de Morais, Sonia, Duignan, David B

“…Human ABCG2 (breast cancer resistance protein, BCRP) is an important efflux transporter which exhibits broad substrate specificity and which is found in many…”
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Synthesis, sar and pharmacology of CP-293,019: A potent, selective dopamine D 4 receptor antagonist by Sanner, Mark A., Chappie, Thomas A., Dunaiskis, Audrey R., Fliri, Anton F., Desai, Kishor A., Zorn, Stevin H., Jackson, Elisa R., Johnson, Celeste G., Morrone, Jean M., Seymour, Patricia A., Majchrzak, Mark J., Stephen Faraci, W., Collins, Judith L., Duignan, David B., Di Prete, Cecilia C., Lee, Jae S., Trozzi, Angela

“…A series of novel, potent and selective pyrido[1,2- a]pyrazine dopamine D 4 receptor antagonists are reported including CP-293,019 (D 4 K i = 3.4 nM, D 2 K i >…”
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