Search Results - "Dugué, Laurence"

First-in-class allosteric inhibitors of bacterial IMPDHs by Alexandre, Thomas, Lupan, Alexandru, Helynck, Olivier, Vichier-Guerre, Sophie, Dugué, Laurence, Gelin, Muriel, Haouz, Ahmed, Labesse, Gilles, Munier-Lehmann, Hélène

“…Inosine-5‘-monophosphate dehydrogenase (IMPDH) is an essential enzyme in many bacterial pathogens and is considered as a potential drug target for the…”
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Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4 by Reolon, Lidia Watanabe, Vichier-Guerre, Sophie, de Matos, Bruno Moisés, Dugué, Laurence, Assunção, Tatiana Reichert da Silva, Zanchin, Nilson Ivo Tonin, Pochet, Sylvie, Guimarães, Beatriz Gomes

“…Association of the initiation factor eIF4E with the mRNA cap structure is a key step for translation. Trypanosomatids present six eIF4E homologues, showing a…”
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Structural analysis of the Trypanosoma brucei EIF4E6/EIF4G5 complex reveals details of the interaction between unusual eIF4F subunits by Penteado, Renato Ferras, da Silva, Renata Santana, Moura, Danielle Maria Nascimento, de Lima, Gustavo Barbosa, Malvezzi, Amaranta Muniz, Monteiro, Tallyta Tâmara da Silva, Xavier, Camila Cavalcanti, Vichier-Guerre, Sophie, Dugué, Laurence, Pochet, Sylvie, Zanchin, Nilson Ivo Tonin, Reis, Christian Robson de Souza, de Melo Neto, Osvaldo Pompílio, Guimarães, Beatriz Gomes

“…Recognition of the mRNA 5′ end is a critical step needed for translation initiation. This step is performed by the cap binding protein eIF4E, which joins the…”
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From Substrate to Fragments to Inhibitor Active In Vivo against Staphylococcus aureus by Gelin, Muriel, Paoletti, Julie, Nahori, Marie-Anne, Huteau, Valérie, Leseigneur, Clarisse, Jouvion, Grégory, Dugué, Laurence, Clément, David, Pons, Jean-Luc, Assairi, Liliane, Pochet, Sylvie, Labesse, Gilles, Dussurget, Olivier

“…Antibiotic resistance is a worldwide threat due to the decreasing supply of new antimicrobials. Novel targets and innovative strategies are urgently needed to…”
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A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki–Miyaura cross-coupling reaction by Vichier-Guerre, Sophie, Dugué, Laurence, Pochet, Sylvie

“…[Display omitted] A simple and rapid access to a variety of 4(5)-arylated imidazoles via palladium-catalyzed Suzuki–Miyaura cross-coupling reaction is…”
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In Vivo Reshaping the Catalytic Site of Nucleoside 2′-Deoxyribosyltransferase for Dideoxy- and Didehydronucleosides via a Single Amino Acid Substitution by Kaminski, Pierre Alexandre, Dacher, Priscilla, Dugué, Laurence, Pochet, Sylvie

“…Nucleoside 2′-deoxyribosyltransferases catalyze the transfer of 2-deoxyribose between bases and have been widely used as biocatalysts to synthesize a variety…”
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Screening and In Situ Synthesis Using Crystals of a NAD Kinase Lead to a Potent Antistaphylococcal Compound by Gelin, Muriel, Poncet-Montange, Guillaume, Assairi, Liliane, Morellato, Laurence, Huteau, Valérie, Dugué, Laurence, Dussurget, Olivier, Pochet, Sylvie, Labesse, Gilles

“…Making new ligands for a given protein by in situ ligation of building blocks (or fragments) is an attractive method. However, it suffers from inherent…”
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Substrate specificity of vaccinia virus thymidylate kinase by Topalis, Dimitri, Collinet, Bruno, Gasse, Cécile, Dugué, Laurence, Balzarini, Jan, Pochet, Sylvie, Deville‐Bonne, Dominique

“…Anti‐poxvirus therapies are currently limited to cidofovir [(S)‐1‐(3‐hydroxy‐2‐phosphonylmethoxypropyl)cytosine], but drug‐resistant strains have already been…”
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Nucleotide binding to human UMP‐CMP kinase using fluorescent derivatives − a screening based on affinity for the UMP‐CMP binding site by Topalis, Dimitri, Kumamoto, Hiroki, Amaya Velasco, Maria‐Fernanda, Dugué, Laurence, Haouz, Ahmed, Alexandre, Julie Anne C., Gallois‐Montbrun, Sarah, Alzari, Pedro Maria, Pochet, Sylvie, Agrofoglio, Luigi André, Deville‐Bonne, Dominique

“…Methylanthraniloyl derivatives of ATP and CDP were used in vitro as fluorescent probes for the donor‐binding and acceptor‐binding sites of human UMP‐CMP…”
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Probing the Substrate Recognition Mechanism of the Human MTH1 Protein by Nucleotide Analogs by Kamiya, Hiroyuki, Yakushiji, Hiroyuki, Dugué, Laurence, Tanimoto, Mitsuhide, Pochet, Sylvie, Nakabeppu, Yusaku, Harashima, Hideyoshi

“…To examine the substrate recognition mechanism of the human MTH1 protein, which hydrolyzes 2-hydroxy-dATP, 8-hydroxy-dATP, and 8-hydroxy-dGTP, ten nucleotide…”
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Nucleoside Analogues as Inhibitors of Thymidylate Kinases: Possible Therapeutic Applications by Pochet, Sylvie, Dugue, Laurence, Douguet, Dominique, Labesse, Gilles, Munier-Lehmann, Hélène

“…Membrane‐permeable nonphosphorylated thymidine analogues (see structure) are active as competitive inhibitors of M. tuberculosis thymidylate kinase (TMPK) as…”
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Synthesis and recognition by DNA polymerases of a reactive nucleoside, 1-(2-deoxy-β-d-erythro-pentofuranosyl)-imidazole-4-hydrazide by Strobel, Heike, Dugué, Laurence, Marlière, Philippe, Pochet, Sylvie

“…We report the synthesis of a new nucleoside, 1‐(2‐deoxy-β-d-erythro-pentofuranosyl)-imidazole-4-hydrazide (dYNH2) as a reactive monomer for DNA…”
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Looking for New Pyrimidine Acyclic Nucleotide Analogues Designed for Phosphorylation by Human Ump-Cmp Kinase by Topalis, Dimitri, Kumamoto, Hiroki, Alexandre, Julie A. C., Dugué, Laurence, Pochet, Sylvie, Berteina-Raboin, Sabine, Agrofoglio, Luigi A., Deville-Bonne, Dominique

“…Human UMP-CMP kinase is involved in the phosphorylation of nucleic acid precursors and also in the activation of antiviral analogues including cidofovir, an…”
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Corrigendum to “A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki–Miyaura cross-coupling reaction” [Tetrahedron Lett. 55 (2014) 6347–6350] by Vichier-Guerre, Sophie, Dugué, Laurence, Pochet, Sylvie

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3‘-C-Branched-Chain-Substituted Nucleosides and Nucleotides as Potent Inhibitors of Mycobacterium tuberculosis Thymidine Monophosphate Kinase by VANHEUSDEN, Veerle, MUNIER-LEHMANN, Hélène, FROEYEN, Matheus, DUGUé, Laurence, HEYERICK, Arne, DE KEUKELEIRE, Denis, POCHET, Sylvie, BUSSON, Roger, HERDEWIJN, Piet, VAN CALENBERGH, Serge

“…Thymidine monophosphate kinase (TMPK) of Mycobacterium tuberculosis (TMPKmt) represents an attractive target for blocking the bacterial DNA synthesis. In an…”
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Recognition of Nucleotide Analogs Containing the 7,8-Dihydro-8-oxo Structure by the Human MTH1 Protein by Kamiya, Hiroyuki, Cadena-Amaro, Claudio, Dugué, Laurence, Yakushiji, Hiroyuki, Minakawa, Noriaki, Matsuda, Akira, Pochet, Sylvie, Nakabeppu, Yusaku, Harashima, Hideyoshi

“…The MTH1 protein catalyzes hydrolysis of oxidatively damaged purine nucleotides including 8-hydroxy-dGTP to the monophosphates. The MTH1 protein seems to act…”
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Expedient and generic synthesis of imidazole nucleosides by enzymatic transglycosylation by Vichier-Guerre, S, Dugué, L, Bonhomme, F, Pochet, S

“…A straightforward route to original imidazole-based nucleosides that makes use of an enzymatic N-transglycosylation step is reported in both the ribo- and…”
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Comparative Study of Purine and Pyrimidine Nucleoside Analogues Acting on the Thymidylate Kinases of Mycobacterium tuberculosis and of Humans by Pochet, Sylvie, Dugué, Laurence, Labesse, Gilles, Delepierre, Muriel, Munier-Lehmann, Hélène

“…Thymidine monophosphate kinase (TMPK) from Mycobacterium tuberculosis (TMPKmt) is an attractive target for the design of specific inhibitors. This fact is the…”
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Substrate recognition by the human MTH1 protein by Kamiya, Hiroyuki, Dugué, Laurence, Yakushiji, Hiroyuki, Pochet, Sylvie, Nakabeppu, Yusaku, Harashima, Hideyoshi

“…A nucleotide pool sanitizing enzyme, the human MTH1 protein, hydrolyzes 2-hydroxy-dATP, 8-hydroxy-dATP, and 8-hydroxyd-GTP. To examine the substrate…”
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3‘-C-Branched-Chain-Substituted Nucleosides and Nucleotides as Potent Inhibitors of Mycobacterium t uberculosis Thymidine Monophosphate Kinase by Vanheusden, Veerle, Munier-Lehmann, Hélène, Froeyen, Matheus, Dugué, Laurence, Heyerick, Arne, De Keukeleire, Denis, Pochet, Sylvie, Busson, Roger, Herdewijn, Piet, Van Calenbergh, Serge

“…Thymidine monophosphate kinase (TMPK) of Mycobacterium tuberculosis (TMPKmt) represents an attractive target for blocking the bacterial DNA synthesis. In an…”
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