Search Results - "Duggan, Ryan"

Nitric oxide production by monocytes in children with OSA and endothelial dysfunction by Kheirandish-Gozal, Leila, Wang, Yang, Duggan, Ryan C, Harshan Vardhan, Sindhuja, Tan, Hui-Leng, Molero Ramirez, Helena, Khalyfa, Abdelnaby, Bhattacharjee, Rakesh, Bandla, Hari P R, Gozal, David

“…OSA (obstructive sleep apnoea) is associated with a higher risk for alterations in post-occlusive hyperaemia, an eNOS (endothelial NO synthase)-dependent…”
Get more information

Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes by Sundaravel, Sriram, Duggan, Ryan, Bhagat, Tushar, Ebenezer, David L, Liu, Hui, Yu, Yiting, Bartenstein, Matthias, Unnikrishnan, Madhu, Karmakar, Subhradip, Liu, Ting-Chun, Torregroza, Ingrid, Quenon, Thomas, Anastasi, John, McGraw, Kathy L, Pellagatti, Andrea, Boultwood, Jacqueline, Yajnik, Vijay, Artz, Andrew, Le Beau, Michelle M, Steidl, Ulrich, List, Alan F, Evans, Todd, Verma, Amit, Wickrema, Amittha

“…Anemia is the predominant clinical manifestation of myelodysplastic syndromes (MDS). Loss or deletion of chromosome 7 is commonly seen in MDS and leads to a…”
Get full text

Navitoclax safety, tolerability, and effect on biomarkers of senescence and neurodegeneration in aged nonhuman primates by Greenberg, Edward F., Voorbach, Martin J., Smith, Alexandra, Reuter, David R., Zhuang, Yuchuan, Wang, Ji-Quan, Wooten, Dustin W., Asque, Elizabeth, Hu, Min, Hoft, Carolin, Duggan, Ryan, Townsend, Matthew, Orsi, Karin, Dalecki, Karen, Amberg, Willi, Duggan, Lori, Knight, Heather, Spina, Joseph S., He, Yupeng, Marsh, Kennan, Zhao, Vivian, Ybarra, Suzanne, Mollon, Jennifer, Fang, Yuni, Vasanthakumar, Aparna, Westmoreland, Susan, Droescher, Mathias, Finnema, Sjoerd J., Florian, Hana

“…Alzheimer's disease (AD) is the most common global dementia and is universally fatal. Most late-stage AD disease-modifying therapies are intravenous and target…”
Get full text

Flow Cytometric Analysis of Phosphorylated Histone H2AX Following Exposure to Ionizing Radiation in Human Microvascular Endothelial Cells by Kataoka, Yasushi, Bindokas, Vytautas P, Duggan, Ryan C, Murley, Jeffrey S, Grdina, David J

“…We applied a flow cytometric method to quantify IR-induced histone H2AX phosphorylation at serine 139 (γH2AX) and compared those values to those obtained using…”
Get full text

1403-A PTPN2/N1 inhibitor ABBV-CLS-484 unleashes potent anti-tumor immunity by Ebrahimi-Nik, Hakimeh, Baumgartner, Christina K, Iracheta-Vellve, Arvin, Hamel, Keith M, Olander, Kira, Davis, Thomas GR, McGuire, Kathleen A, Halvorsen, Geoff T, Avila, Omar I, Patel, Chirag, Kim, Sarah, Kammula, Ashwin V, Muscato, Audrey J, Halliwill, Kyle, Geda, Prasanthi, Klinge, Kelly, Xiong, Zhaoming, Duggan, Ryan, Mu, Liang, Yeary, Mitchell D, Patti, James C, Balon, Tyler M, Mathew, Rebecca, Backus, Carey, Kennedy, Domenick, Chen, Angeline, Longenecker, Kenton, Klahn, Joseph, Hrusch, Cara, Krishnan, Navasona, Hutchins, Charles W, Aguado, Jacqueline, Bulic, Marinka, Tiwari, Payal, Colvin, Kayla J, Chuong, Cun Lan, Kohnle, Ian C, Rees, Matthew G, Boghossian, Andrew, Ronan, Melissa, Roth, Jennifer A, Wu, Meng-Ju, Sen, Debattama R, Griffin, Gabriel K, El-Bardeesy, Nabeel, Trusk, Patricia, Sun, Meng, Liu, Yue, Decker, Joshua H, Yang, Yi, Fossey, Stacey, Qiu, Wei, Sun, Qi, Paddock, Marcia N, Farney, Elliot P, Beauregard, Clay, Frost, Jennifer M, Yates, Kathleen B, Kym, Philip R, Manguso, Robert T

“…BackgroundImmune checkpoint blockade is effective for a subset of patients across many cancers, but most patients are refractory to current immunotherapies and…”
Get full text

DNA-Directed Assembly of Antibody-Fluorophore Conjugates for Quantitative Multiparametric Flow Cytometry by Flor, Amy C., Williams, Jimmy H., Blaine, Kelly M., Duggan, Ryan C., Sperling, Anne I., Schwartz, David A., Kron, Stephen J.

“…Multiparametric flow cytometry offers a powerful approach to single‐cell analysis with broad applications in research and diagnostics. Despite advances in…”
Get full text

The Burden of False-Positive Results in Analog and Digital Screening Mammography: Experience of the Nova Scotia Breast Screening Program by Payne, Jennifer I., PhD, Martin, Tetyana, BSc, MD, FRCP, Caines, Judy S., MD, FRCP, Duggan, Ryan, BHSc, RTR, MHI

“…Abstract Purpose The Canadian Task Force on Preventive Health Care released recommendations for breast cancer screening, in part, based on harms associated…”
Get full text

Research: The Perspective of a Recent MRT Graduate by Duggan, Ryan, BHSc, RTR, MHI(c)

Get full text

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors by Woo, Seng-Ryong, Fuertes, Mercedes B., Corrales, Leticia, Spranger, Stefani, Furdyna, Michael J., Leung, Michael Y.K., Duggan, Ryan, Wang, Ying, Barber, Glen N., Fitzgerald, Katherine A., Alegre, Maria-Luisa, Gajewski, Thomas F.

“…Spontaneous T cell responses against tumors occur frequently and have prognostic value in patients. The mechanism of innate immune sensing of immunogenic…”
Get full text

ChatGPT performance on radiation technologist and therapist entry to practice exams by Duggan, Ryan, Tsuruda, Kaitlyn M.

“…The aim of this study was to describe the proficiency of ChatGPT (GPT-4) on certification style exams from the Canadian Association of Medical Radiation…”
Get full text

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity by Baumgartner, Christina K., Ebrahimi-Nik, Hakimeh, Iracheta-Vellve, Arvin, Hamel, Keith M., Olander, Kira E., Davis, Thomas G. R., McGuire, Kathleen A., Halvorsen, Geoff T., Avila, Omar I., Patel, Chirag H., Kim, Sarah Y., Kammula, Ashwin V., Muscato, Audrey J., Halliwill, Kyle, Geda, Prasanthi, Klinge, Kelly L., Xiong, Zhaoming, Duggan, Ryan, Mu, Liang, Yeary, Mitchell D., Patti, James C., Balon, Tyler M., Mathew, Rebecca, Backus, Carey, Kennedy, Domenick E., Chen, Angeline, Longenecker, Kenton, Klahn, Joseph T., Hrusch, Cara L., Krishnan, Navasona, Hutchins, Charles W., Dunning, Jax P., Bulic, Marinka, Tiwari, Payal, Colvin, Kayla J., Chuong, Cun Lan, Kohnle, Ian C., Rees, Matthew G., Boghossian, Andrew, Ronan, Melissa, Roth, Jennifer A., Wu, Meng-Ju, Suermondt, Juliette S. M. T., Knudsen, Nelson H., Cheruiyot, Collins K., Sen, Debattama R., Griffin, Gabriel K., Golub, Todd R., El-Bardeesy, Nabeel, Decker, Joshua H., Yang, Yi, Guffroy, Magali, Fossey, Stacey, Trusk, Patricia, Sun, Im-Meng, Liu, Yue, Qiu, Wei, Sun, Qi, Paddock, Marcia N., Farney, Elliot P., Matulenko, Mark A., Beauregard, Clay, Frost, Jennifer M., Yates, Kathleen B., Kym, Philip R., Manguso, Robert T.

“…Immune checkpoint blockade is effective for some patients with cancer, but most are refractory to current immunotherapies and new approaches are needed to…”
Get full text

IL-23 induces regulatory T cell plasticity with implications for inflammatory skin diseases by Kannan, Arun K., Su, Zhi, Gauvin, Donna M., Paulsboe, Stephanie E., Duggan, Ryan, Lasko, Loren M., Honore, Prisca, Kort, Michael E., McGaraughty, Steve P., Scott, Victoria E., Gauld, Stephen B.

“…Foxp3 + regulatory T cells (Tregs) represent a major fraction of skin resident T cells. Although normally protective, Tregs have been shown to produce…”
Get full text

Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth by Girard, Romuald, Zeineddine, Hussein A, Koskimäki, Janne, Fam, Maged D, Cao, Ying, Shi, Changbin, Moore, Thomas, Lightle, Rhonda, Stadnik, Agnieszka, Chaudagar, Kiranj, Polster, Sean, Shenkar, Robert, Duggan, Ryan, Leclerc, David, Whitehead, Kevin J, Li, Dean Y, Awad, Issam A

“…RATIONALE:The clinical course of cerebral cavernous malformations is highly unpredictable, with few cross-sectional studies correlating proinflammatory…”
Get full text

Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report by Tighe, Robert M, Redente, Elizabeth F, Yu, Yen-Rei, Herold, Susanne, Sperling, Anne I, Curtis, Jeffrey L, Duggan, Ryan, Swaminathan, Suchitra, Nakano, Hideki, Zacharias, William J, Janssen, William J, Freeman, Christine M, Brinkman, Ryan R, Singer, Benjamin D, Jakubzick, Claudia V, Misharin, Alexander V

“…Defining responses of the structural and immune cells in biologic systems is critically important to understanding disease states and responses to injury. This…”
Get full text

ABBV-319: a CD19-targeting glucocorticoid receptor modulator antibody-drug conjugate therapy for B-cell malignancies by Chang, Chewei Anderson, Emberley, Ethan, D'Souza, Aloma L., Zhao, Weilong, Cosgrove, Cormac, Parrish, Karen, Mitra, Diya, Payson, Elmer, Oleksijew, Anatol, Ellis, Paul, Rodriguez, Luis, Duggan, Ryan, Hrusch, Cara, Lasko, Loren, Assaily, Wissam, Zheng, Pingping, Liu, Wei, Hernandez, Axel, McCarthy, Kimberley, Zhang, Zhaomei, Rha, Geunbae, Cao, Zhensheng, Li, Yingchun, Perng, Olivia, Campbell, Jos, Zhang, Gloria, Curran, Tyler, Bruncko, Milan, Marvin, Christopher C., Hobson, Adrian, McPherson, Michael, Uziel, Tamar, Pysz, Marybeth A., Zhao, Xi, Bankovich, Alex, Hayflick, Joel, McDevitt, Michael, Freise, Kevin J., Morgan-Lappe, Susan, Purcell, James W.

“…•ABBV-319 has 3 mechanisms of action that contributed to significant antitumor activity across preclinical models of B-cell malignancy.•ABBV-319 delivers a…”
Get full text

Pregnancy loss in individuals with von Willebrand disease and unspecified mucocutaneous bleeding disorders: A multicentre cohort study by Skeith, Leslie, James, Paula, Kouides, Peter, Uminski, Kelsey, Duffett, Lisa, Jackson, Shannon, Sholzberg, Michelle, Ragni, Margaret V, Cuker, Adam, O'Beirne, Maeve, Hews-Girard, Julia, Rydz, Natalia, Goodyear, Dawn M, Baxter, Jill, James, Andra, Garcia, David, Vesely, Sara K, Poon, Man-Chiu

“…While bleeding around pregnancy is well described in von Willebrand disease (VWD), risk of pregnancy loss is less certain. We aimed to describe the frequency…”
Get full text

The Head Injury Symptoms Checklist (HISC) as a Potential Screening Tool for PPCS in TBI (P3.320) by Creque, Chava, Duggan, Ryan, Adams, Christopher, Asiedu, Nana, Tseretopoulos, Irene, Ghajar, Jamshid

“…Abstract only…”
Get full text

The BCL-2-Selective Inhibitor Venetoclax Spares Activated T-Cells during Anti-Tumor Immunity by Mathew, Rebecca, Haribhai, Dipica, Kohlhapp, Fred, Duggan, Ryan, Ellis, Paul, Riehm, Jacob J, Robinson, Valerie A, Shi, Yan Y, Bhathena, Anahita, Leverson, Joel D., Pappano, William N, Donawho, Cherrie K, Uziel, Tamar

“…Introduction and objectives: During an adaptive immune response antigen-specific T cells rapidly proliferate and differentiate into cytotoxic T lymphocytes…”
Get full text

Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations by Girard, Romuald, Zeineddine, Hussein A., Fam, Maged D., Mayampurath, Anoop, Cao, Ying, Shi, Changbin, Shenkar, Robert, Polster, Sean P., Jesselson, Michael, Duggan, Ryan, Mikati, Abdul-Ghani, Christoforidis, Gregory, Andrade, Jorge, Whitehead, Kevin J., Li, Dean Y., Awad, Issam A.

“…The clinical course of cerebral cavernous malformations (CCMs) is highly variable. Based on recent discoveries implicating angiogenic and inflammatory…”
Get full text

Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses by Slivka, Peter F, Hsieh, Chen-Lin, Lipovsky, Alex, Pratt, Steven D, Locklear, John, Namovic, Marian T, McDonald, Heath A, Wetter, Joseph, Edelmayer, Rebecca, Hu, Min, Murphy, Erin, Domanus, Marc, Lu, Charles, Duggan, Ryan, King, Jacob, Scott, Victoria E, Donnelly-Roberts, Diana, Slavin, Anthony, Gopalakrishnan, Sujatha, Chung, Namjin, Goedken, Eric R

“…Interleukin-17A (IL17A) plays a critical role in the development of numerous autoimmune diseases, including psoriasis. The clinical success of IL17A…”
Get full text