Search Results - "Duggan, Michael"

Microglia and modifiable life factors: Potential contributions to cognitive resilience in aging by Duggan, Michael R., Parikh, Vinay

“…Given the increasing prevalence of age-related cognitive decline, it is relevant to consider the factors and mechanisms that might facilitate an individual’s…”
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Organ-specific aging in the plasma proteome predicts disease by Duggan, Michael R., Walker, Keenan A.

“…In their recent Nature paper, Oh et al. use 4979 plasma proteins collected across multiple cohorts, publicly available gene expression data, and machine…”
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An injectable shear-thinning biomaterial for endovascular embolization by Avery, Reginald K, Albadawi, Hassan, Akbari, Mohsen, Zhang, Yu Shrike, Duggan, Michael J, Sahani, Dushyant V, Olsen, Bradley D, Khademhosseini, Ali, Oklu, Rahmi

“…Improved endovascular embolization of vascular conditions can generate better patient outcomes and minimize the need for repeat procedures. However, many…”
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PAM (PIK3/AKT/mTOR) signaling in glia: potential contributions to brain tumors in aging by Duggan, Michael R, Weaver, Michael, Khalili, Kamel

“…Despite a growing proportion of aged individuals at risk for developing cancer in the brain, the prognosis for these conditions remains abnormally poor due to…”
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Emerging Role of Nef in the Development of HIV Associated Neurological Disorders by Yarandi, Shadan S, Duggan, Michael R, Sariyer, Ilker K

“…Despite adherence to treatment, individuals living with HIV have an increased risk for developing cognitive impairments, referred to as HIV-associated…”
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Cognitive trajectories in longitudinally trained 3xTg-AD mice by Duggan, Michael R, Steinberg, Zoe, Peterson, Tara, Francois, Tara-Jade, Parikh, Vinay

“…Preclinical studies in Alzheimer's disease (AD) often rely on cognitively naïve animal models in cross-sectional designs that can fail to reflect the cognitive…”
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Herpes Viruses in the Baltimore Longitudinal Study of Aging: Associations With Brain Volumes, Cognitive Performance, and Plasma Biomarkers by Duggan, Michael R., Peng, Zhongsheng, An, Yang, Kitner Triolo, Melissa H., Shafer, Andrea T., Davatzikos, Christos, Erus, Guray, Karikkineth, Ajoy, Lewis, Alexandria, Moghekar, Abhay, Walker, Keenan A.

“…Although an infectious etiology of Alzheimer disease (AD) has received renewed attention with a particular focus on herpes viruses, the longitudinal effects of…”
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Navigational Mapping Practices: Contexts, Politics, Data by Duggan, Michael

“…Maps communicate meaning to the practices and experiences of navigation in everyday life. This is ever more the case in a world where GPS, geo-spatial and…”
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Plasma proteins related to inflammatory diet predict future cognitive impairment by Duggan, Michael R., Butler, Lauren, Peng, Zhongsheng, Daya, Gulzar N., Moghekar, Abhay, An, Yang, Rapp, Stephen R., Hayden, Kathleen M., Shadyab, Aladdin H., Natale, Ginny, Liu, Longjian, Snetselaar, Linda, Moaddel, Ruin, Rebholz, Casey M., Sullivan, Kevin, Ballantyne, Christie M., Resnick, Susan M., Ferrucci, Luigi, Walker, Keenan A.

“…Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which…”
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Plasma biomarkers for Alzheimer’s and related dementias: A review and outlook for clinical neuropsychology by Dark, Heather E, Duggan, Michael R, Walker, Keenan A

“…Abstract Recent technological advances have improved the sensitivity and specificity of blood-based biomarkers for Alzheimer’s disease and related dementias…”
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Tolerance, Intolerance, and Recognition in Early Christianity and Early Judaism ed. by Outi Lehtipuu and Michael Labahn (review) by Duggan, Michael W

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The role of peripheral inflammatory insults in Alzheimer's disease: a review and research roadmap by Walker, Keenan A, Le Page, Lydia M, Terrando, Niccolò, Duggan, Michael R, Heneka, Michael T, Bettcher, Brianne M

“…Peripheral inflammation, defined as inflammation that occurs outside the central nervous system, is an age-related phenomenon that has been identified as a…”
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Treatment of a urethral stricture by image‐guided placement of a custom‐made absorbable stent in a standing, sedated horse by Baltrimaite, Milda, Kearney, Clodagh, O'Brien, Anne, Duggan, Michael, Cuq, Benoît

“…A 10‐year‐old Irish Sport Horse gelding developed complications from a general anesthesia resulting in sling support and recurrent urinary catheterization. The…”
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Association of liver disease with brain volume loss, cognitive decline, and plasma neurodegenerative disease biomarkers by Peng, Zhongsheng, Duggan, Michael R., Dark, Heather E., Daya, Gulzar N., An, Yang, Davatzikos, Christos, Erus, Guray, Lewis, Alexandria, Moghekar, Abhay R., Walker, Keenan A.

“…Although liver dysfunction has been implicated in Alzheimer's disease (AD), it remains unknown how liver disease may influence the trajectory of brain and…”
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Chemogenetic inhibition of prefrontal projection neurons constrains top–down control of attention in young but not aged rats by Duggan, Michael R., Joshi, Surbhi, Strupp, Jacob, Parikh, Vinay

“…The prefrontal cortex (PFC) governs top–down control of attention and is known to be vulnerable in aging. Cortical reorganization with increased PFC…”
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Self-expanding foam versus preperitoneal packing for exsanguinating pelvic hemorrhage by King, David Richard, Hwabejire, John O, Pham, Quynh P, Elsharkawy, Ahmed E, Eid, Ahmed I, Duggan, Michael J, Gelsinger, Shawn, Fornaciari, Michael, Sharma, Upma

“…Mortality for pelvic fracture patients presenting with hemorrhagic shock ranges from 21% to 57%. The objective of this study was to develop a lethal and…”
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Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life by Walker, Keenan A, Chen, Jingsha, Shi, Liu, Yang, Yunju, Fornage, Myriam, Zhou, Linda, Schlosser, Pascal, Surapaneni, Aditya, Grams, Morgan E, Duggan, Michael R, Peng, Zhongsheng, Gomez, Gabriela T, Tin, Adrienne, Hoogeveen, Ron C, Sullivan, Kevin J, Ganz, Peter, Lindbohm, Joni V, Kivimaki, Mika, Nevado-Holgado, Alejo J, Buckley, Noel, Gottesman, Rebecca F, Mosley, Thomas H, Boerwinkle, Eric, Ballantyne, Christie M, Coresh, Josef

“…A diverse set of biological processes have been implicated in the pathophysiology of Alzheimer's disease (AD) and related dementias. However, there is limited…”
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Identification of Clinically Relevant Brain Endothelial Cell Biomarkers in Plasma by Cordon, Jenifer, Duggan, Michael R, Gomez, Gabriela T, Pucha, Krishna A, Peng, Zhongsheng, Dark, Heather E, Davatzikos, Christos, Erus, Guray, Lewis, Alexandria, Moghekar, Abhay, Candia, Julián, Ferrucci, Luigi, Kapogiannis, Dimitrios, Walker, Keenan A

“…Proteins expressed by brain endothelial cells (BECs), the primary cell type of the blood-brain barrier, may serve as sensitive plasma biomarkers for…”
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Stress Regulation of Sustained Attention and the Cholinergic Attention System by Eck, Samantha R., Xu, Song-Jun, Telenson, Alexander, Duggan, Michael R., Cole, Robert, Wicks, Brittany, Bergmann, Joy, Lefebo, Hanna, Shore, Marni, Shepard, Katherine A., Akins, Michael R., Parikh, Vinay, Heller, Elizabeth A., Bangasser, Debra A.

“…Stress exacerbates symptoms of schizophrenia and attention-deficit/hyperactivity disorder, which are characterized by impairments in sustained attention. Yet…”
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Proteomic Indicators of Health Predict Alzheimer's Disease Biomarker Levels and Dementia Risk by Dark, Heather E., Paterson, Clare, Daya, Gulzar N., Peng, Zhongsheng, Duggan, Michael R., Bilgel, Murat, An, Yang, Moghekar, Abhay, Davatzikos, Christos, Resnick, Susan M., Loupy, Kelsey, Simpson, Missy, Candia, Julián, Mosley, Thomas, Coresh, Josef, Palta, Priya, Ferrucci, Luigi, Shapiro, Allison, Williams, Stephen A., Walker, Keenan A.

“…Objective Few studies have comprehensively examined how health and disease risk influence Alzheimer's disease (AD) biomarkers. The present study examined the…”
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