Search Results - "Dugan, L"

Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model by Naviaux, Robert K, Zolkipli, Zarazuela, Wang, Lin, Nakayama, Tomohiro, Naviaux, Jane C, Le, Thuy P, Schuchbauer, Michael A, Rogac, Mihael, Tang, Qingbo, Dugan, Laura L, Powell, Susan B

“…Autism spectrum disorders (ASDs) are caused by both genetic and environmental factors. Mitochondria act to connect genes and environment by regulating…”
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The Social Mediatization of Lifestyle Sport: Continuity and Novelty in the Online Skate Subculture by Nichols, L. Dugan

“…Based on mediatization theory, this article tracks how skateboarders experience and negotiate the entry of social media into their subculture. Building on…”
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Interleukin-6 Mediates the Increase in NADPH-Oxidase in the Ketamine Model of Schizophrenia by Behrens, M. Margarita, Ali, Sameh S, Dugan, Laura L

“…Adult exposure to NMDA receptor antagonists, such as ketamine, produces psychosis in humans, and exacerbates symptoms in schizophrenic patients. We recently…”
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Ketamine-Induced Loss of Phenotype of Fast-Spiking Interneurons Is Mediated by NADPH-Oxidase by Behrens, M. Margarita, Ali, Sameh S, Dao, Diep N, Lucero, Jacinta, Shekhtman, Grigoriy, Quick, Kevin L, Dugan, Laura L

“…Abuse of the dissociative anesthetic ketamine can lead to a syndrome indistinguishable from schizophrenia. In animals, repetitive exposure to this…”
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Evolution of antibody immunity following Omicron BA.1 breakthrough infection by Kaku, Chengzi I., Starr, Tyler N., Zhou, Panpan, Dugan, Haley L., Khalifé, Paul, Song, Ge, Champney, Elizabeth R., Mielcarz, Daniel W., Geoghegan, James C., Burton, Dennis R., Andrabi, Raiees, Bloom, Jesse D., Walker, Laura M.

“…Understanding the longitudinal dynamics of antibody immunity following heterologous SAR-CoV-2 breakthrough infection will inform the development of…”
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SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike by Guthmiller, Jenna J, Stovicek, Olivia, Wang, Jiaolong, Changrob, Siriruk, Li, Lei, Halfmann, Peter, Zheng, Nai-Ying, Utset, Henry, Stamper, Christopher T, Dugan, Haley L, Miller, William D, Huang, Min, Dai, Ya-Nan, Nelson, Christopher A, Hall, Paige D, Jansen, Maud, Shanmugarajah, Kumaran, Donington, Jessica S, Krammer, Florian, Fremont, Daved H, Joachimiak, Andrzej, Kawaoka, Yoshihiro, Tesic, Vera, Madariaga, Maria Lucia, Wilson, Patrick C

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently causing a global pandemic. The antigen specificity of the antibody response mounted…”
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The Functional Movement Screen: a reliability study by Teyhen, Deydre S, Shaffer, Scott W, Lorenson, Chelsea L, Halfpap, Joshua P, Donofry, Dustin F, Walker, Michael J, Dugan, Jessica L, Childs, John D

“…Reliability study. To determine intrarater test-retest and interrater reliability of the Functional Movement Screen (FMS) among novice raters. The FMS is used…”
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IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase by Dugan, Laura L, Ali, Sameh S, Shekhtman, Grigoriy, Roberts, Amanda J, Lucero, Jacinta, Quick, Kevin L, Behrens, M Margarita

“…Multiple studies have shown that plasma levels of the pro-inflammatory cytokine interleukin-6 (IL-6) are elevated in patients with important and prevalent…”
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Vaccination of SARS-CoV-2-infected individuals expands a broad range of clonally diverse affinity-matured B cell lineages by Chernyshev, Mark, Sakharkar, Mrunal, Connor, Ruth I., Dugan, Haley L., Sheward, Daniel J., Rappazzo, C. G., Stålmarck, Aron, Forsell, Mattias N. E., Wright, Peter F., Corcoran, Martin, Murrell, Ben, Walker, Laura M., Karlsson Hedestam, Gunilla B.

“…Vaccination of SARS-CoV-2 convalescent individuals generates broad and potent antibody responses. Here, we isolate 459 spike-specific monoclonal antibodies…”
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Gnarly Freelancers: Professional Skateboarders’ Labor and Social-Media Use in the Neoliberal Economy by Nichols, L. Dugan

“…The working conditions of professional skateboarders are rarely investigated in academic literature or traditional skate media (e.g., Thrasher Magazine). This…”
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Development of a PET radiotracer for non-invasive imaging of the reactive oxygen species, superoxide, in vivo by Chu, Wenhua, Chepetan, Andre, Zhou, Dong, Shoghi, Kooresh I, Xu, Jinbin, Dugan, Laura L, Gropler, Robert J, Mintun, Mark A, Mach, Robert H

“…Reactive oxygen species (ROS) have been implicated in the pathogenesis of a wide range of human disease states and drug toxicities, but development of imaging…”
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The Neurofibromatosis 1 Gene Product Neurofibromin Regulates Pituitary Adenylate Cyclase-Activating Polypeptide-Mediated Signaling in Astrocytes by Dasgupta, Biplab, Dugan, Laura L, Gutmann, David H

“…Individuals with the neurofibromatosis 1 (NF1)-inherited tumor predisposition syndrome develop low-grade astrocytomas. The NF1 tumor suppressor gene product…”
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Distinct Mechanisms Underlie Neurotoxin-Mediated Cell Death in Cultured Dopaminergic Neurons by Lotharius, Julie, Dugan, Laura L, O'Malley, Karen L

“…Oxidative stress is thought to contribute to dopaminergic cell death in Parkinson's disease (PD). The neurotoxin 6-hydroxydopamine (6-OHDA), which is easily…”
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Cross-Neutralization of Emerging SARS-CoV-2 Variants of Concern by Antibodies Targeting Distinct Epitopes on Spike by Changrob, Siriruk, Fu, Yanbin, Guthmiller, Jenna J, Halfmann, Peter J, Li, Lei, Stamper, Christopher T, Dugan, Haley L, Accola, Molly, Rehrauer, William, Zheng, Nai-Ying, Huang, Min, Wang, Jiaolong, Erickson, Steven A, Utset, Henry A, Graves, Hortencia M, Amanat, Fatima, Sather, D Noah, Krammer, Florian, Kawaoka, Yoshihiro, Wilson, Patrick C

“…Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have arisen that exhibit increased viral transmissibility and partial evasion of…”
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Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality by Badawy, Mohamed A, Yasseen, Basma A, El-Messiery, Riem M, Abdel-Rahman, Engy A, Elkhodiry, Aya A, Kamel, Azza G, El-Sayed, Hajar, Shedra, Asmaa M, Hamdy, Rehab, Zidan, Mona, Al-Raawi, Diaa, Hammad, Mahmoud, Elsharkawy, Nahla, El Ansary, Mohamed, Al-Halfawy, Ahmed, Elhadad, Alaa, Hatem, Ashraf, Abouelnaga, Sherif, Dugan, Laura L, Ali, Sameh Saad

“…Human serum albumin (HSA) is the frontline antioxidant protein in blood with established anti-inflammatory and anticoagulation functions. Here, we report that…”
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Hypoxia-adaptation involves mitochondrial metabolic depression and decreased ROS leakage by Ali, Sameh S, Hsiao, Mary, Zhao, Huiwen W, Dugan, Laura L, Haddad, Gabriel G, Zhou, Dan

“…Through long-term laboratory selection, we have generated a Drosophila melanogaster population that tolerates severe, normally lethal, level of hypoxia. This…”
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Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation by Hou, Catherine, Hsieh, Chia-Ju, Li, Shihong, Lee, Hsiaoju, Graham, Thomas J, Xu, Kuiying, Weng, Chi-Chang, Doot, Robert K, Chu, Wenhua, Chakraborty, Subhasish K, Dugan, Laura L, Mintun, Mark A, Mach, Robert H

“…Reactive oxygen species (ROS) are believed to play a major role in the proinflammatory, M1-polarized form of neuroinflammation. However, it has been difficult…”
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A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice by Quick, Kevin L, Ali, Sameh S, Arch, Robert, Xiong, Chengjie, Wozniak, David, Dugan, Laura L

“…Abstract In lower organisms, such as Caenorhabditis elegans and Drosophila , many genes identified as key regulators of aging are involved in either…”
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A Genome-Wide CRISPR/Cas9-Based Screen Identifies Heparan Sulfate Proteoglycans as Ligands of Killer-Cell Immunoglobulin-Like Receptors by Klein, Klara, Hölzemer, Angelique, Wang, Tim, Kim, Tae-Eun, Dugan, Haley L, Jost, Stephanie, Altfeld, Marcus, Garcia-Beltran, Wilfredo F

“…While human leukocyte antigen (HLA) and HLA-like proteins comprise an overwhelming majority of known ligands for NK-cell receptors, the interactions of NK-cell…”
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Metabolic Depression and Increased Reactive Oxygen Species Production by Isolated Mitochondria at Moderately Lower Temperatures by Ali, Sameh S., Marcondes, Maria-Cecilia Garibaldi, Bajova, Hilda, Dugan, Laura L., Conti, Bruno

“…Temperature (T) reduction increases lifespan, but the mechanisms are not understood. Because reactive oxygen species (ROS) contribute to aging, we hypothesized…”
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