Search Results - "Dugan, Haley"

Aging and influenza vaccine-induced immunity by Dugan, Haley L., Henry, Carole, Wilson, Patrick C.

“…•Vaccine effectiveness is reduced in the elderly population because of immunosenescence.•New vaccine strategies should focus on countering…”
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Proinflammatory IgG Fc structures in patients with severe COVID-19 by Chakraborty, Saborni, Gonzalez, Joseph, Edwards, Karlie, Mallajosyula, Vamsee, Buzzanco, Anthony S., Sherwood, Robert, Buffone, Cindy, Kathale, Nimish, Providenza, Susan, Xie, Markus M., Andrews, Jason R., Blish, Catherine A., Singh, Upinder, Dugan, Haley, Wilson, Patrick C., Pham, Tho D., Boyd, Scott D., Nadeau, Kari C., Pinsky, Benjamin A., Zhang, Sheng, Memoli, Matthew J., Taubenberger, Jeffery K., Morales, Tasha, Schapiro, Jeffrey M., Tan, Gene S., Jagannathan, Prasanna, Wang, Taia T.

“…Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild…”
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Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1 by Garcia-Beltran, Wilfredo F, Hölzemer, Angelique, Martrus, Gloria, Chung, Amy W, Pacheco, Yovana, Simoneau, Camille R, Rucevic, Marijana, Lamothe-Molina, Pedro A, Pertel, Thomas, Kim, Tae-Eun, Dugan, Haley, Alter, Galit, Dechanet-Merville, Julie, Jost, Stephanie, Carrington, Mary, Altfeld, Marcus

“…The activating NK cell receptor KIR3DS1 has been linked to the outcome of various human diseases, yet a ligand that would account for its biological effects…”
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Evolution of antibody immunity following Omicron BA.1 breakthrough infection by Kaku, Chengzi I., Starr, Tyler N., Zhou, Panpan, Dugan, Haley L., Khalifé, Paul, Song, Ge, Champney, Elizabeth R., Mielcarz, Daniel W., Geoghegan, James C., Burton, Dennis R., Andrabi, Raiees, Bloom, Jesse D., Walker, Laura M.

“…Understanding the longitudinal dynamics of antibody immunity following heterologous SAR-CoV-2 breakthrough infection will inform the development of…”
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Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial by Bernstein, David I, Guptill, Jeffrey, Naficy, Abdollah, Nachbagauer, Raffael, Berlanda-Scorza, Francesco, Feser, Jodi, Wilson, Patrick C, Solórzano, Alicia, Van der Wielen, Marie, Walter, Emmanuel B, Albrecht, Randy A, Buschle, Kristen N, Chen, Yao-qing, Claeys, Carine, Dickey, Michelle, Dugan, Haley L, Ermler, Megan E, Freeman, Debra, Gao, Min, Gast, Christopher, Guthmiller, Jenna J, Hai, Rong, Henry, Carole, Lan, Linda Yu-Ling, McNeal, Monica, Palm, Anna-Karin E, Shaw, Dustin G, Stamper, Christopher T, Sun, Weina, Sutton, Victoria, Tepora, Micah E, Wahid, Rahnuma, Wenzel, Heather, Wohlbold, Teddy John, Innis, Bruce L, García-Sastre, Adolfo, Palese, Peter, Krammer, Florian

“…Influenza viruses cause substantial annual morbidity and mortality globally. Current vaccines protect against influenza only when well matched to the…”
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SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike by Guthmiller, Jenna J, Stovicek, Olivia, Wang, Jiaolong, Changrob, Siriruk, Li, Lei, Halfmann, Peter, Zheng, Nai-Ying, Utset, Henry, Stamper, Christopher T, Dugan, Haley L, Miller, William D, Huang, Min, Dai, Ya-Nan, Nelson, Christopher A, Hall, Paige D, Jansen, Maud, Shanmugarajah, Kumaran, Donington, Jessica S, Krammer, Florian, Fremont, Daved H, Joachimiak, Andrzej, Kawaoka, Yoshihiro, Tesic, Vera, Madariaga, Maria Lucia, Wilson, Patrick C

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently causing a global pandemic. The antigen specificity of the antibody response mounted…”
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Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans by Dugan, Haley L, Guthmiller, Jenna J, Arevalo, Philip, Huang, Min, Chen, Yao-Qing, Neu, Karlynn E, Henry, Carole, Zheng, Nai-Ying, Lan, Linda Yu-Ling, Tepora, Micah E, Stovicek, Olivia, Bitar, Dalia, Palm, Anna-Karin E, Stamper, Christopher T, Changrob, Siriruk, Utset, Henry A, Coughlan, Lynda, Krammer, Florian, Cobey, Sarah, Wilson, Patrick C

“…Humans are repeatedly exposed to variants of influenza virus throughout their lifetime. As a result, preexisting influenza-specific memory B cells can dominate…”
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First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes by Guthmiller, Jenna J, Han, Julianna, Li, Lei, Freyn, Alec W, Liu, Sean T H, Stovicek, Olivia, Stamper, Christopher T, Dugan, Haley L, Tepora, Micah E, Utset, Henry A, Bitar, Dalia J, Hamel, Natalie J, Changrob, Siriruk, Zheng, Nai-Ying, Huang, Min, Krammer, Florian, Nachbagauer, Raffael, Palese, Peter, Ward, Andrew B, Wilson, Patrick C

“…Broadly neutralizing antibodies are critical for protection against both drifted and shifted influenza viruses. Here, we reveal that first exposure to the 2009…”
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Vaccination of SARS-CoV-2-infected individuals expands a broad range of clonally diverse affinity-matured B cell lineages by Chernyshev, Mark, Sakharkar, Mrunal, Connor, Ruth I., Dugan, Haley L., Sheward, Daniel J., Rappazzo, C. G., Stålmarck, Aron, Forsell, Mattias N. E., Wright, Peter F., Corcoran, Martin, Murrell, Ben, Walker, Laura M., Karlsson Hedestam, Gunilla B.

“…Vaccination of SARS-CoV-2 convalescent individuals generates broad and potent antibody responses. Here, we isolate 459 spike-specific monoclonal antibodies…”
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Cross-Neutralization of Emerging SARS-CoV-2 Variants of Concern by Antibodies Targeting Distinct Epitopes on Spike by Changrob, Siriruk, Fu, Yanbin, Guthmiller, Jenna J, Halfmann, Peter J, Li, Lei, Stamper, Christopher T, Dugan, Haley L, Accola, Molly, Rehrauer, William, Zheng, Nai-Ying, Huang, Min, Wang, Jiaolong, Erickson, Steven A, Utset, Henry A, Graves, Hortencia M, Amanat, Fatima, Sather, D Noah, Krammer, Florian, Kawaoka, Yoshihiro, Wilson, Patrick C

“…Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have arisen that exhibit increased viral transmissibility and partial evasion of…”
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A Genome-Wide CRISPR/Cas9-Based Screen Identifies Heparan Sulfate Proteoglycans as Ligands of Killer-Cell Immunoglobulin-Like Receptors by Klein, Klara, Hölzemer, Angelique, Wang, Tim, Kim, Tae-Eun, Dugan, Haley L, Jost, Stephanie, Altfeld, Marcus, Garcia-Beltran, Wilfredo F

“…While human leukocyte antigen (HLA) and HLA-like proteins comprise an overwhelming majority of known ligands for NK-cell receptors, the interactions of NK-cell…”
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Teach ‘em young: Influenza vaccines induce broadly neutralizing antibodies in children by Dugan, Haley L., Wilson, Patrick C.

“…Antibodies against the influenza virus hemagglutinin stalk afford broad protection against antigenically drifted viruses. In this issue of Cell Reports…”
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Epitopes recognition of SARS-CoV-2 nucleocapsid RNA binding domain by human monoclonal antibodies by Kim, Youngchang, Maltseva, Natalia, Tesar, Christine, Jedrzejczak, Robert, Endres, Michael, Ma, Heng, Dugan, Haley L., Stamper, Christopher T., Chang, Changsoo, Li, Lei, Changrob, Siriruk, Zheng, Nai-Ying, Huang, Min, Ramanathan, Arvind, Wilson, Patrick, Michalska, Karolina, Joachimiak, Andrzej

“…Coronavirus nucleocapsid protein (NP) of SARS-CoV-2 plays a central role in many functions important for virus proliferation including packaging and protecting…”
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Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity by Briquez, Priscilla S, Rouhani, Sherin J, Yu, Jovian, Pyzer, Athalia R, Trujillo, Jonathan, Dugan, Haley L, Stamper, Christopher T, Changrob, Siriruk, Sperling, Anne I, Wilson, Patrick C, Gajewski, Thomas F, Hubbell, Jeffrey A, Swartz, Melody A

“…Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can experience life-threatening respiratory distress, blood pressure…”
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Librator: a platform for the optimized analysis, design, and expression of mutable influenza viral antigens by Li, Lei, Changrob, Siriruk, Fu, Yanbin, Stovicek, Olivia, Guthmiller, Jenna J, McGrath, Joshua J C, Dugan, Haley L, Stamper, Christopher T, Zheng, Nai-Ying, Huang, Min, Wilson, Patrick C

“…Abstract Artificial mutagenesis and protein engineering have laid the foundation for antigenic characterization and universal vaccine design for influenza…”
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Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets by Dugan, Haley L., Stamper, Christopher T., Li, Lei, Changrob, Siriruk, Asby, Nicholas W., Halfmann, Peter J., Zheng, Nai-Ying, Huang, Min, Shaw, Dustin G., Cobb, Mari S., Erickson, Steven A., Guthmiller, Jenna J., Stovicek, Olivia, Wang, Jiaolong, Winkler, Emma S., Madariaga, Maria Lucia, Shanmugarajah, Kumaran, Jansen, Maud O., Amanat, Fatima, Stewart, Isabelle, Utset, Henry A., Huang, Jun, Nelson, Christopher A., Dai, Ya-Nan, Hall, Paige D., Jedrzejczak, Robert P., Joachimiak, Andrzej, Krammer, Florian, Diamond, Michael S., Fremont, Daved H., Kawaoka, Yoshihiro, Wilson, Patrick C.

“…Dissecting the evolution of memory B cells (MBCs) against SARS-CoV-2 is critical for understanding antibody recall upon secondary exposure. Here, we used…”
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Influence of Glycosylation Inhibition on the Binding of KIR3DL1 to HLA-B57:01 by Salzberger, Wilhelm, Garcia-Beltran, Wilfredo F, Dugan, Haley, Gubbala, Supreetha, Simoneau, Camille, Gressens, Simon B, Jost, Stephanie, Altfeld, Marcus

“…Viral infections can affect the glycosylation pattern of glycoproteins involved in antiviral immunity. Given the importance of protein glycosylation for immune…”
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Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses by Guthmiller, Jenna J., Lan, Linda Yu-Ling, Fernández-Quintero, Monica L., Han, Julianna, Utset, Henry A., Bitar, Dalia J., Hamel, Natalie J., Stovicek, Olivia, Li, Lei, Tepora, Micah, Henry, Carole, Neu, Karlynn E., Dugan, Haley L., Borowska, Marta T., Chen, Yao-Qing, Liu, Sean T.H., Stamper, Christopher T., Zheng, Nai-Ying, Huang, Min, Palm, Anna-Karin E., García-Sastre, Adolfo, Nachbagauer, Raffael, Palese, Peter, Coughlan, Lynda, Krammer, Florian, Ward, Andrew B., Liedl, Klaus R., Wilson, Patrick C.

“…Polyreactivity is the ability of a single antibody to bind to multiple molecularly distinct antigens and is a common feature of antibodies induced upon…”
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Improved integration of single-cell transcriptome and surface protein expression by LinQ-View by Li, Lei, Dugan, Haley L., Stamper, Christopher T., Lan, Linda Yu-Ling, Asby, Nicholas W., Knight, Matthew, Stovicek, Olivia, Zheng, Nai-Ying, Madariaga, Maria Lucia, Shanmugarajah, Kumaran, Jansen, Maud O., Changrob, Siriruk, Utset, Henry A., Henry, Carole, Nelson, Christopher, Jedrzejczak, Robert P., Fremont, Daved H., Joachimiak, Andrzej, Krammer, Florian, Huang, Jun, Khan, Aly A., Wilson, Patrick C.

“…Multimodal advances in single-cell sequencing have enabled the simultaneous quantification of cell surface protein expression alongside unbiased…”
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Semaphorin 7A modulates cytokine‐induced memory‐like responses by human natural killer cells by Ghofrani, Joshua, Lucar, Olivier, Dugan, Haley, Reeves, R. Keith, Jost, Stephanie

“…Cytokine‐induced memory‐like (CIML) NK cells are endowed with the capacity to mediate enhanced effector functions upon cytokine or activating receptor…”
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