Search Results - "Dugan, Benjamin"

Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators by Mesaros, Eugen F, Cole, Andrew G, Kultgen, Steven G, Mani, Nagraj, Fan, Kristi Yi, Dugan, Benjamin J, Ardzinski, Andrzej, Stever, Kim, Micolochick Steuer, Holly M, Graves, Ingrid, Tang, Sunny, Harasym, Troy O, Lam, Angela M, Thi, Emily P, Dorsey, Bruce D, Sofia, Michael J

“…Isoquinolinone-based HBV capsid assembly modulators that bind at the dimer:dimer interface of HBV core protein have been shown to suppress viral replication in…”
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Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2 by Lu, Lily D, Stump, Kristine L, Wallace, Nate H, Dobrzanski, Pawel, Serdikoff, Cynthia, Gingrich, Diane E, Dugan, Benjamin J, Angeles, Thelma S, Albom, Mark S, Mason, Jennifer L, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce A, Seavey, Matthew M

“…Accumulating evidence suggests that autoreactive plasma cells play an important role in systemic lupus erythematosus (SLE). In addition, several…”
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A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-a]pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779 by Dugan, Benjamin J, Gingrich, Diane E, Mesaros, Eugen F, Milkiewicz, Karen L, Curry, Matthew A, Zulli, Allison L, Dobrzanski, Pawel, Serdikoff, Cynthia, Jan, Mahfuza, Angeles, Thelma S, Albom, Mark S, Mason, Jennifer L, Aimone, Lisa D, Meyer, Sheryl L, Huang, Zeqi, Wells-Knecht, Kevin J, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D

“…Members of the JAK family of nonreceptor tyrosine kinases play a critical role in the growth and progression of many cancers and in inflammatory diseases. JAK2…”
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Discovery of C‑Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV‑2 by Mesaros, Eugen F., Dugan, Benjamin J., Gao, Min, Sheraz, Muhammad, McGovern-Gooch, Kayleigh, Xu, Fran, Fan, Kristi Yi, Nguyen, Duyan, Kultgen, Steven G., Lindstrom, Aaron, Stever, Kim, Tercero, Breanna, Binder, Randall J., Liu, Fei, Micolochick Steuer, Holly M., Mani, Nagraj, Harasym, Troy O., Thi, Emily P., Cuconati, Andrea, Dorsey, Bruce D., Cole, Andrew G., Lam, Angela M., Sofia, Michael J.

“…The recent COVID-19 pandemic underscored the limitations of currently available direct-acting antiviral treatments against acute respiratory RNA-viral…”
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Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models by Mesaros, Eugen F., Burke, Jason P., Parrish, Jonathan D., Dugan, Benjamin J., Anzalone, Andrew V., Angeles, Thelma S., Albom, Mark S., Aimone, Lisa D., Quail, Matthew R., Wan, Weihua, Lu, Lihui, Huang, Zeqi, Ator, Mark A., Ruggeri, Bruce A., Cheng, Mangeng, Ott, Gregory R., Dorsey, Bruce D.

“…The synthesis and biological evaluation of potent and selective anaplastic lymphoma kinase (ALK) inhibitors from a novel class of 2,4-diaminopyrimidines,…”
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Oxygen distributions in tissue measured by phosphorescence quenching by Vinogradov, Sergei A, Grosul, Pavel, Rozhkov, Vladimir, Dunphy, Isolde, Shuman, Lee, Dugan, Benjamin W, Evans, Sydney, Wilson, David F

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Measurement of tumor oxygenation using new frequency domain phosphorometers by Wilson, David F, Vinogradov, Sergei A, Dugan, Benjamin W, Biruski, Dubravko, Waldron, Lee, Evans, Sydney A

“…Oxygen dependent quenching of phosphorescence allows for non-invasive measurements of oxygen in tissue. We have designed and constructed a novel…”
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Structure-Activity Relationships and Discovery of (S)-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6H-pyrido1,2-h1,7naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer by Gotchev, Dimitar, Dorsey, Bruce D, Nguyen, Duyan, Kakarla, Ramesh, Dugan, Benjamin, Chen, Shuai, Gao, Min, Bailey, Laurèn, Liu, Fei, Harasym, Troy, Chiu, Tim, Tang, Sunny, Lee, Amy C-H, Cole, Andrew G, Sofia, Michael J

“…Approved therapies for hepatitis B virus (HBV) treatment include nucleos(t)ides and interferon alpha (IFN-α) which effectively suppress viral replication, but…”
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Structure–Activity Relationships and Discovery of ( S )-5-( tert -Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido[2′,1′:2,3]imidazo[4,5- h ]quinoline-3-carboxylic Acid (AB-161), a Novel Orally Available and Liver-Centric HBV RNA Destabilizer by Gotchev, Dimitar, Chen, Shuai, Dugan, Benjamin, Dorsey, Bruce D., Wang, Xu, Sheraz, Muhammad, Kowalski, Rose, Liu, Fei, Tang, Sunny, Chiu, Tim, Harasym, Troy, Graves, Ingrid E., Thi, Emily P., Mason, Jeremy D., Overholt, Nathan, Dugyala, Ravi, Lam, Angela M., Cole, Andrew G., Sofia, Michael J.

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Structure-Activity Relationships and Discovery of (S)-5-(tert-Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido2',1':2,3imidazo4,5-hquinoline-3-carboxylic Acid (AB-161), a Novel Orally Available and Liver-Centric HBV RNA Destabilizer by Gotchev, Dimitar, Chen, Shuai, Dugan, Benjamin, Dorsey, Bruce D, Wang, Xu, Sheraz, Muhammad, Kowalski, Rose, Liu, Fei, Tang, Sunny, Chiu, Tim, Harasym, Troy, Graves, Ingrid E, Thi, Emily P, Mason, Jeremy D, Overholt, Nathan, Dugyala, Ravi, Lam, Angela M, Cole, Andrew G, Sofia, Michael J

“…Lowering hepatitis B surface antigen (HBsAg) levels from covalently closed circular DNA (cccDNA) and the integrated genome could reduce the persistence of…”
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Structure–Activity Relationships and Discovery of (S)‑6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro‑6H‑pyrido[1,2‑h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer by Gotchev, Dimitar, Dorsey, Bruce D., Nguyen, Duyan, Kakarla, Ramesh, Dugan, Benjamin, Chen, Shuai, Gao, Min, Bailey, Laurèn, Liu, Fei, Harasym, Troy, Chiu, Tim, Tang, Sunny, Lee, Amy C.-H., Cole, Andrew G., Sofia, Michael J.

“…Approved therapies for hepatitis B virus (HBV) treatment include nucleos­(t)­ides and interferon alpha (IFN-α) which effectively suppress viral replication,…”
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Structure-Activity Relationships and Discovery of ( S )-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6 H -pyrido[1,2- h ][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer by Gotchev, Dimitar, Dorsey, Bruce D, Nguyen, Duyan, Kakarla, Ramesh, Dugan, Benjamin, Chen, Shuai, Gao, Min, Bailey, Laurèn, Liu, Fei, Harasym, Troy, Chiu, Tim, Tang, Sunny, Lee, Amy C-H, Cole, Andrew G, Sofia, Michael J

“…Approved therapies for hepatitis B virus (HBV) treatment include nucleos(t)ides and interferon alpha (IFN-α) which effectively suppress viral replication, but…”
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Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein–Ligand Complexes by Cansfield, Andrew D, Ator, Mark A, Banerjee, Joydeep, Bestwick, Michael, Bortolato, Andrea, Brown, Giles A, Brown, Jason, Butkovic, Kristina, Cansfield, Julie E, Christopher, John A, Congreve, Miles, Cseke, Gabriella, Deflorian, Francesca, Dugan, Benjamin, Hunjadi, Martina Petrovic, Hutinec, Antun, Inturi, Trinadh Kumar, Landek, Goran, Mason, Jonathan, O’Brien, Alistair, Ott, Gregory R, Rupcic, Renata, Saxty, Gordon, Southall, Stacey M, Zadravec, Rahela, Watson, Stephen P

“…A series of macrocyclic calcitonin gene-related peptide (CGRP) receptor antagonists identified using structure-based design principles, exemplified by…”
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Corrigendum to “Novel 2,3,4,5-tetrahydro-benzo[ d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models” [Bioorg. Med. Chem. Lett. 21 (2011) 463] by Mesaros, Eugen F., Burke, Jason P., Parrish, Jonathan D., Dugan, Benjamin J., Anzalone, Andrew V., Angeles, Thelma S., Albom, Mark S., Aimone, Lisa D., Quail, Matthew R., Wan, Weihua, Lu, Lihui, Huang, Zeqi, Ator, Mark A., Ruggeri, Bruce A., Cheng, Mangeng, Ott, Gregory R., Dorsey, Bruce D.

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