Search Results - "Dufu, K."

Antibody mimics based on human fibronectin type three domain engineered for thermostability and high-affinity binding to vascular endothelial growth factor receptor two by Parker, M.H., Chen, Y., Danehy, F., Dufu, K., Ekstrom, J., Getmanova, E., Gokemeijer, J., Xu, L., Lipovsek, D.

“…The tenth human fibronectin type three domain (10Fn3) is a small (10 kDa), extremely stable and soluble protein with an immunoglobulin-like fold, but without…”
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GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease by Oksenberg, Donna, Dufu, Kobina, Patel, Mira P., Chuang, Chihyuan, Li, Zhe, Xu, Qing, Silva‐Garcia, Abel, Zhou, Chengjing, Hutchaleelaha, Athiwat, Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C., Sinha, Uma, Metcalf, Brian W., Archer, David R.

“…Summary A major driver of the pathophysiology of sickle cell disease (SCD) is polymerization of deoxygenated haemoglobin S (HbS), which leads to sickling and…”
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PS1522 CENTRAL PHYSIOLOGIC MECHANISMS WHICH AUGMENT OXYGEN RELEASE (BOHR EFFECT AND 2,3‐DPG BINDING) ARE PRESERVED IN THE PRESENCE OF VOXELOTOR AT THE THERAPEUTIC TARGET OF 30% HB MODIFICATION by Pochron, M., Siu, V., Oksenberg, D., Dufu, K.

“…Background: Key physiologic mechanisms that drive O2 offloading to tissues in vivo include the Bohr effect and 2,3‐DPG binding. The Bohr effect is the capacity…”
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C105 RESPIRATORY FAILURE: MECHANISTIC INSIGHTS FROM LUNG INJURY MODELS: Gbt1118, A Drug That Increases Oxygen Affinity Of Hemoglobin, Improved Survival During Murine Hypoxic Acute Lung Injury by Putz, N D, Shaver, C M, Dufu, K, Li, C-M, Xu, Q, Hutchaleelaha, A, Lehrer-Graiwer, J, Bastarache, J A, Ware, L B

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Functional coupling of RNAP II transcription to spliceosome assembly by Das, Rita, Dufu, Kobina, Romney, Ben, Feldt, Megan, Elenko, Mark, Reed, Robin

“…The pathway of gene expression in higher eukaryotes involves a highly complex network of physical and functional interactions among the different machines…”
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