Search Results - "Duffy, Megan F"

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration by Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Luk, Kelvin C, Tansey, Malú G, Paumier, Katrina L, Kanaan, Nicholas M, Fischer, D Luke, Polinski, Nicole K, Barth, Olivia L, Howe, Jacob W, Vaikath, Nishant N, Majbour, Nour K, El-Agnaf, Omar M A, Sortwell, Caryl E

“…Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson's disease (PD). Animal models of PD can serve as a platform to…”
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Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils by Patterson, Joseph R., Duffy, Megan F., Kemp, Christopher J., Howe, Jacob W., Collier, Timothy J., Stoll, Anna C., Miller, Kathryn M., Patel, Pooja, Levine, Nathan, Moore, Darren J., Luk, Kelvin C., Fleming, Sheila M., Kanaan, Nicholas M., Paumier, Katrina L., El-Agnaf, Omar M.A., Sortwell, Caryl E.

“…Animal models that accurately recapitulate the accumulation of alpha-synuclein (α-syn) inclusions, progressive neurodegeneration of the nigrostriatal system…”
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Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition by Stoll, Anna C, Kemp, Christopher J, Patterson, Joseph R, Kubik, Michael, Kuhn, Nathan, Benskey, Matthew, Duffy, Megan F, Luk, Kelvin C, Sortwell, Caryl E

“…Parkinson's disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn) inclusions (Lewy…”
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The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats by Mercado, Natosha M., Stancati, Jennifer A., Sortwell, Caryl E., Mueller, Rebecca L., Boezwinkle, Samuel A., Duffy, Megan F., Fischer, D. Luke, Sandoval, Ivette M., Manfredsson, Fredric P., Collier, Timothy J., Steece-Collier, Kathy

“…Prevalent in approximately 20% of the worldwide human population, the rs6265 (also called ‘Val66Met’) single nucleotide polymorphism (SNP) in the gene for…”
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Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson's Disease by Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Fischer, D Luke, Stoll, Anna C, Sortwell, Caryl E

“…Animal models have significantly advanced our understanding of Parkinson's disease (PD). Alpha-synuclein (α-syn) has taken center stage due to its genetic…”
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Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils by Patterson, Joseph R., Kochmanski, Joseph, Stoll, Anna C., Kubik, Michael, Kemp, Christopher J., Duffy, Megan F., Thompson, Kajene, Howe, Jacob W., Cole-Strauss, Allyson, Kuhn, Nathan C., Miller, Kathryn M., Nelson, Seth, Onyekpe, Christopher U., Beck, John S., Counts, Scott E., Bernstein, Alison I., Steece-Collier, Kathy, Luk, Kelvin C., Sortwell, Caryl E.

“…Examination of early phases of synucleinopathy when inclusions are present, but long before neurodegeneration occurs, is critical to both understanding disease…”
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Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein by Patterson, Joseph R., Hirst, Warren D., Howe, Jacob W., Russell, Christopher P., Cole-Strauss, Allyson, Kemp, Christopher J., Duffy, Megan F., Lamp, Jared, Umstead, Andrew, Kubik, Michael, Stoll, Anna C., Vega, Irving E., Steece-Collier, Kathy, Chen, Yi, Campbell, Anne C., Nezich, Catherine L., Glajch, Kelly E., Sortwell, Caryl E.

“…β2-adrenoreceptor (β2AR) agonists have been associated with a decreased risk of developing Parkinson’s disease (PD) and are hypothesized to decrease expression…”
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Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration by Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Luk, Kelvin C, Tansey, Malú G, Paumier, Katrina L, Kanaan, Nicholas M, Fischer, D Luke, Polinski, Nicole K, Barth, Olivia L, Howe, Jacob W, Vaikath, Nishant N, Majbour, Nour K, El-Agnaf, Omar M A, Sortwell, Caryl E

“…After publication of the original article [1] it was noted that the name of author, D. Luke Fisher, was erroneously typeset in both the PDF and online formats…”
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Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo by Patterson, Joseph R, Polinski, Nicole K, Duffy, Megan F, Kemp, Christopher J, Luk, Kelvin C, Volpicelli-Daley, Laura A, Kanaan, Nicholas M, Sortwell, Caryl E

“…Use of the in vivo alpha-synuclein preformed fibril (α-syn PFF) model of synucleinopathy is gaining popularity among researchers aiming to model Parkinson's…”
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An ANXA11 P93S variant dysregulates TDP‐43 and causes corticobasal syndrome by Snyder, Allison, Ryan, Veronica H., Hawrot, James, Lawton, Sydney, Ramos, Daniel M., Qi, Y. Andy, Johnson, Kory R., Reed, Xylena, Johnson, Nicholas L., Kollasch, Aaron W., Duffy, Megan F., VandeVrede, Lawren, Cochran, J. Nicholas, Miller, Bruce L., Toro, Camilo, Bielekova, Bibiana, Marks, Debora S., Yokoyama, Jennifer S., Kwan, Justin Y., Cookson, Mark R., Ward, Michael E.

“…INTRODUCTION Variants of uncertain significance (VUS) surged with affordable genetic testing, posing challenges for determining pathogenicity. We examine the…”
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Preformed fibrils generated from mouse alpha-synuclein produce more inclusion pathology in rats than fibrils generated from rat alpha-synuclein by Howe, Jacob W., Sortwell, Caryl E., Duffy, Megan F., Kemp, Christopher J., Russell, Christopher P., Kubik, Michael, Patel, Pooja, Luk, Kelvin C., El-Agnaf, Omar M.A., Patterson, Joseph R.

“…Alpha-synuclein (α-syn) preformed fibril (PFF)-induced pathology can be used to study the features and progression of synucleinopathies, such as Parkinson's…”
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Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression by Fischer, D. Luke, Manfredsson, Fredric P., Kemp, Christopher J., Cole-Strauss, Allyson, Lipton, Jack W., Duffy, Megan F., Polinski, Nicole K., Steece-Collier, Kathy, Collier, Timothy J., Gombash, Sara E., Buhlinger, Daniel J., Sortwell, Caryl E.

“…Subthalamic nucleus deep brain stimulation (STN DBS) protects dopaminergic neurons of the substantia nigra pars compacta (SNpc) against 6-OHDA and MPTP. We…”
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Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson's Disease by Fischer, D Luke, Gombash, Sara E, Kemp, Christopher J, Manfredsson, Fredric P, Polinski, Nicole K, Duffy, Megan F, Sortwell, Caryl E

“…Gene therapy methods are increasingly used to model Parkinson's disease (PD) in animals in an effort to test experimental therapeutics within a more relevant…”
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