Search Results - "Duffy, Fergal J"

Systems analysis of immune responses to attenuated P. falciparum malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunity by Du, Ying, Hertoghs, Nina, Duffy, Fergal J, Carnes, Jason, McDermott, Suzanne M, Neal, Maxwell L, Schwedhelm, Katharine V, McElrath, M Juliana, De Rosa, Stephen C, Aitchison, John D, Stuart, Kenneth D

“…Immunization with radiation-attenuated sporozoites (RAS) can confer sterilizing protection against malaria, although the mechanisms behind this protection are…”
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Contained Mycobacterium tuberculosis infection induces concomitant and heterologous protection by Nemeth, Johannes, Olson, Gregory S, Rothchild, Alissa C, Jahn, Ana N, Mai, Dat, Duffy, Fergal J, Delahaye, Jared L, Srivatsan, Sanjay, Plumlee, Courtney R, Urdahl, Kevin B, Gold, Elizabeth S, Aderem, Alan, Diercks, Alan H

“…Progress in tuberculosis vaccine development is hampered by an incomplete understanding of the immune mechanisms that protect against infection with…”
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Multinomial modelling of TB/HIV co-infection yields a robust predictive signature and generates hypotheses about the HIV+TB+ disease state by Duffy, Fergal J, Thompson, Ethan G, Scriba, Thomas J, Zak, Daniel E

“…Current diagnostics are inadequate to meet the challenges presented by co-infection with Mycobacterium tuberculosis (Mtb) and HIV, the leading cause of death…”
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Distinct immune responses associated with vaccination status and protection outcomes after malaria challenge by Oyong, Damian A, Duffy, Fergal J, Neal, Maxwell L, Du, Ying, Carnes, Jason, Schwedhelm, Katharine V, Hertoghs, Nina, Jun, Seong-Hwan, Miller, Helen, Aitchison, John D, De Rosa, Stephen C, Newell, Evan W, McElrath, M Juliana, McDermott, Suzanne M, Stuart, Kenneth D

“…Understanding immune mechanisms that mediate malaria protection is critical for improving vaccine development. Vaccination with radiation-attenuated Plasmodium…”
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Early whole blood transcriptional responses to radiation-attenuated Plasmodium falciparum sporozoite vaccination in malaria naïve and malaria pre-exposed adult volunteers by Duffy, Fergal J, Du, Ying, Carnes, Jason, Epstein, Judith E, Hoffman, Stephen L, Abdulla, Salim, Jongo, Said, Mpina, Maxmillian, Daubenberger, Claudia, Aitchison, John D, Stuart, Ken

“…Abstract Background Vaccination with radiation-attenuated Plasmodium falciparum sporozoites is known to induce protective immunity. However, the mechanisms…”
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Longitudinal immune profiling after radiation-attenuated sporozoite vaccination reveals coordinated immune processes correlated with malaria protection by Duffy, Fergal J, Hertoghs, Nina, Du, Ying, Neal, Maxwell L, Oyong, Damian, McDermott, Suzanne, Minkah, Nana, Carnes, Jason, Schwedhelm, Katharine V, McElrath, M Juliana, De Rosa, Stephen C, Newell, Evan, Aitchison, John D, Stuart, Ken

“…Identifying immune processes required for liver-stage sterilizing immunity to malaria remains an open problem. The IMRAS trial comprised 5x immunizations with…”
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Preimmunization correlates of protection shared across malaria vaccine trials in adults by Neal, Maxwell L., Duffy, Fergal J., Du, Ying, Aitchison, John D., Stuart, Kenneth D.

“…Identifying preimmunization biological characteristics that promote an effective vaccine response offers opportunities for illuminating the critical…”
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The Peripheral Blood Transcriptome Is Correlated With PET Measures of Lung Inflammation During Successful Tuberculosis Treatment by Odia, Trust, Malherbe, Stephanus T, Meier, Stuart, Maasdorp, Elizna, Kleynhans, Léanie, du Plessis, Nelita, Loxton, Andre G, Zak, Daniel E, Thompson, Ethan, Duffy, Fergal J, Kuivaniemi, Helena, Ronacher, Katharina, Winter, Jill, Walzl, Gerhard, Tromp, Gerard

“…Pulmonary tuberculosis (PTB) is characterized by lung granulomas, inflammation and tissue destruction. Here we used within-subject peripheral blood gene…”
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Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis by Suliman, Sara, Thompson, Ethan G, Sutherland, Jayne, Weiner, 3rd, January, Ota, Martin O C, Shankar, Smitha, Penn-Nicholson, Adam, Thiel, Bonnie, Erasmus, Mzwandile, Maertzdorf, Jeroen, Duffy, Fergal J, Hill, Philip C, Hughes, E Jane, Stanley, Kim, Downing, Katrina, Fisher, Michelle L, Valvo, Joe, Parida, Shreemanta K, van der Spuy, Gian, Tromp, Gerard, Adetifa, Ifedayo M O, Donkor, Simon, Howe, Rawleigh, Mayanja-Kizza, Harriet, Boom, W Henry, Dockrell, Hazel M, Ottenhoff, Tom H M, Hatherill, Mark, Aderem, Alan, Hanekom, Willem A, Scriba, Thomas J, Kaufmann, Stefan H E, Zak, Daniel E, Walzl, Gerhard

“…Contacts of patients with tuberculosis (TB) constitute an important target population for preventive measures because they are at high risk of infection with…”
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Ultra-low Dose Aerosol Infection of Mice with Mycobacterium tuberculosis More Closely Models Human Tuberculosis by Plumlee, Courtney R., Duffy, Fergal J., Gern, Benjamin H., Delahaye, Jared L., Cohen, Sara B., Stoltzfus, Caleb R., Rustad, Tige R., Hansen, Scott G., Axthelm, Michael K., Picker, Louis J., Aitchison, John D., Sherman, David R., Ganusov, Vitaly V., Gerner, Michael Y., Zak, Daniel E., Urdahl, Kevin B.

“…Tuberculosis (TB) is a heterogeneous disease manifesting in a subset of individuals infected with aerosolized Mycobacterium tuberculosis (Mtb). Unlike human…”
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Use of a Contained Mycobacterium tuberculosis Mouse Infection Model to Predict Active Disease and Containment in Humans by Duffy, Fergal J, Olson, Gregory S, Gold, Elizabeth S, Jahn, Ana, Aderem, Alan, Aitchison, John D, Rothchild, Alissa C, Diercks, Alan H, Nemeth, Johannes

“…Abstract Previous studies have identified whole-blood transcriptional risk and disease signatures for tuberculosis; however, several lines of evidence suggest…”
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GlycoProfileAssigner: automated structural assignment with error estimation for glycan LC data by Duffy, Fergal J, Rudd, Pauline M

“…Sequencing glycan structures is a difficult problem that requires the use of multiple experimental approaches. One powerful approach to glycan sequencing is…”
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Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis by Meier, Stuart, Seddon, James A, Maasdorp, Elizna, Kleynhans, Léanie, du Plessis, Nelita, Loxton, Andre G, Malherbe, Stephanus T, Zak, Daniel E, Thompson, Ethan, Duffy, Fergal J, Kaufmann, Stefan H E, Ottenhoff, Tom H M, Scriba, Thomas J, Suliman, Sara, Sutherland, Jayne S, Winter, Jill, Kuivaniemi, Helena, Walzl, Gerhard, Tromp, Gerard

“…Mycobacterium tuberculosis (M.tb) causes tuberculosis (TB) and remains one of the leading causes of mortality due to an infectious pathogen. Host immune…”
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Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis by Stuart Meier, James A Seddon, Elizna Maasdorp, Léanie Kleynhans, Nelita du Plessis, Andre G Loxton, Stephanus T Malherbe, Daniel E Zak, Ethan Thompson, Fergal J Duffy, Stefan H E Kaufmann, Tom H M Ottenhoff, Thomas J Scriba, Sara Suliman, Jayne S Sutherland, Jill Winter, Helena Kuivaniemi, Gerhard Walzl, Gerard Tromp, GC6-74 Consortium, Catalysis TB Biomarkers Consortium

“…Mycobacterium tuberculosis (M.tb) causes tuberculosis (TB) and remains one of the leading causes of mortality due to an infectious pathogen. Host immune…”
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Detection of Tuberculosis Recurrence, Diagnosis and Treatment Response by a Blood Transcriptomic Risk Signature in HIV-Infected Persons on Antiretroviral Therapy by Darboe, Fatoumatta, Mbandi, Stanley Kimbung, Naidoo, Kogieleum, Yende-Zuma, Nonhlanhla, Lewis, Lara, Thompson, Ethan G, Duffy, Fergal J, Fisher, Michelle, Filander, Elizabeth, van Rooyen, Michele, Bilek, Nicole, Mabwe, Simbarashe, McKinnon, Lyle R, Chegou, Novel, Loxton, Andre, Walzl, Gerhard, Tromp, Gerard, Padayatchi, Nesri, Govender, Dhineshree, Hatherill, Mark, Karim, Salim Abdool, Zak, Daniel E, Penn-Nicholson, Adam, Scriba, Thomas J

“…HIV-infected individuals are at high risk of tuberculosis disease and those with prior tuberculosis episodes are at even higher risk of disease recurrence. A…”
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Computational approaches to developing short cyclic peptide modulators of protein-protein interactions by Duffy, Fergal J, Devocelle, Marc, Shields, Denis C

“…Cyclic peptides are a promising class of bioactive molecules potentially capable of modulating "difficult" targets, such as protein-protein interactions…”
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Determinants of brain swelling in pediatric and adult cerebral malaria by Sahu, Praveen K, Duffy, Fergal J, Dankwa, Selasi, Vishnyakova, Maria, Majhi, Megharay, Pirpamer, Lukas, Vigdorovich, Vladimir, Bage, Jabamani, Maharana, Sameer, Mandala, Wilson, Rogerson, Stephen J, Seydel, Karl B, Taylor, Terrie E, Kim, Kami, Sather, D Noah, Mohanty, Akshaya, Mohanty, Rashmi R, Mohanty, Anita, Pattnaik, Rajyabardhan, Aitchison, John D, Hoffmann, Angelika, Mohanty, Sanjib, Smith, Joseph D, Bernabeu, Maria, Wassmer, Samuel C

“…Cerebral malaria (CM) affects children and adults, but brain swelling is more severe in children. To investigate features associated with brain swelling in…”
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CycloPs: Generating Virtual Libraries of Cyclized and Constrained Peptides Including Nonnatural Amino Acids by Duffy, Fergal J, Verniere, Mélanie, Devocelle, Marc, Bernard, Elise, Shields, Denis C, Chubb, Anthony J

“…We introduce CycloPs, software for the generation of virtual libraries of constrained peptides including natural and nonnatural commercially available amino…”
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Virtual Screening Using Combinatorial Cyclic Peptide Libraries Reveals Protein Interfaces Readily Targetable by Cyclic Peptides by Duffy, Fergal J, O’Donovan, Darragh, Devocelle, Marc, Moran, Niamh, O’Connell, David J, Shields, Denis C

“…Protein–protein and protein–peptide interactions are responsible for the vast majority of biological functions in vivo, but targeting these interactions with…”
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Computational survey of peptides derived from disulphide-bonded protein loops that may serve as mediators of protein-protein interactions by Duffy, Fergal J, Devocelle, Marc, Croucher, David R, Shields, Denis C

“…Bioactive cyclic peptides derived from natural sources are well studied, particularly those derived from non-ribosomal synthetases in fungi or bacteria…”
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