Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry

Most familial hypercholesterolemia (FH) patients remain undertreated, and it is unclear what role health disparities may play for FH patients in the US. We sought to describe sex and racial/ethnic disparities in a national registry of US FH patients. We analyzed data from 3167 adults enrolled in the...

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Bibliographic Details
Published in:	Atherosclerosis Vol. 267; pp. 19 - 26
Main Authors:	Amrock, Stephen M., Duell, P. Barton, Knickelbine, Thomas, Martin, Seth S., O'Brien, Emily C., Watson, Karol E., Mitri, Joanna, Kindt, Iris, Shrader, Peter, Baum, Seth J., Hemphill, Linda C., Ahmed, Catherine D., Andersen, Rolf L., Kullo, Iftikhar J., McCann, Dervilla, Larry, John A., Murray, Michael F., Fishberg, Robert, Guyton, John R., Wilemon, Katherine, Roe, Matthew T., Rader, Daniel J., Ballantyne, Christie M., Underberg, James A., Thompson, Paul, Duffy, Dannielle, Linton, MacRae F., Shapiro, Michael D., Moriarty, Patrick M., Knowles, Joshua W., Ahmad, Zahid S.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01-12-2017
Subjects:	Adult African Americans Aged Asian Americans Cardiovascular Diseases - metabolism Cholesterol, HDL - metabolism Cholesterol, LDL - blood Disparities Ethnic Groups Ethnicity Familial hypercholesterolemia Female Health Status Disparities Healthcare Disparities Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hyperlipidemia Hyperlipoproteinemia Type II - blood Hyperlipoproteinemia Type II - diagnosis Hyperlipoproteinemia Type II - ethnology Male Middle Aged Multicenter Studies as Topic Odds Ratio Phenotype Prospective Studies Race Registries Retrospective Studies Risk Factors Sex Sex Factors Ethnicity FH Hyperlipidemia ASCVD LDL-C Race Sex PCSK9 Disparities Familial hypercholesterolemia
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Summary:	Most familial hypercholesterolemia (FH) patients remain undertreated, and it is unclear what role health disparities may play for FH patients in the US. We sought to describe sex and racial/ethnic disparities in a national registry of US FH patients. We analyzed data from 3167 adults enrolled in the CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia (CASCADE-FH) registry. Logistic regression was used to evaluate for disparities in LDL-C goals and statin use, with adjustments for covariates including age, cardiovascular risk factors, and statin intolerance. In adjusted analyses, women were less likely than men to achieve treated LDL-C of <100 mg/dL (OR 0.68, 95% CI, 0.57–0.82) or ≥50% reduction from pretreatment LDL-C (OR 0.79, 95% CI, 0.65–0.96). Women were less likely than men to receive statin therapy (OR, 0.60, 95% CI, 0.50–0.73) and less likely to receive a high-intensity statin (OR, 0.60, 95% CI, 0.49–0.72). LDL-C goal achievement also varied by race/ethnicity: compared with whites, Asians and blacks were less likely to achieve LDL-C levels <100 mg/dL (Asians, OR, 0.47, 95% CI, 0.24–0.94; blacks, OR, 0.49, 95% CI, 0.32–0.74) or ≥50% reduction from pretreatment LDL-C (Asians, OR 0.56, 95% CI, 0.32–0.98; blacks, OR 0.62, 95% CI, 0.43–0.90). In a contemporary US population of FH patients, we identified differences in LDL-C goal attainment and statin usage after stratifying the population by either sex or race/ethnicity. Our findings suggest that health disparities contribute to the undertreatment of US FH patients. Increased efforts are warranted to raise awareness of these disparities. •Disparities by sex and race/ethnicity were noted in US lipid clinics.•Women were less likely than men to achieve LDL-C goals and to receive statins.•Asians and blacks were 40–50% less likely to achieve LDL-C goals than whites.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0021-9150 1879-1484
DOI:	10.1016/j.atherosclerosis.2017.10.006