Search Results - "Duffy, Cayla M"

Identification of a fatty acid binding protein4-UCP2 axis regulating microglial mediated neuroinflammation by Duffy, Cayla M., Xu, Hongliang, Nixon, Joshua P., Bernlohr, David A., Butterick, Tammy A.

“…Hypothalamic inflammation contributes to metabolic dysregulation and the onset of obesity. Dietary saturated fats activate microglia via a nuclear factor-kappa…”
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Role of orexin A signaling in dietary palmitic acid-activated microglial cells by Duffy, Cayla M., Yuan, Ce, Wisdorf, Lauren E., Billington, Charles J., Kotz, Catherine M., Nixon, Joshua P., Butterick, Tammy A.

“…•Palmitic acid (PA) increases microglial orexin receptor 1 expression.•PA increases microglial pro-inflammatory cytokine release.•Orexin A reduces microglial…”
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Microglial FABP4-UCP2 Axis Modulates Neuroinflammation and Cognitive Decline in Obese Mice by So, Simon W, Fleming, Kendra M, Duffy, Cayla M, Nixon, Joshua P, Bernlohr, David A, Butterick, Tammy A

“…The microglial fatty-acid-binding protein 4-uncoupling protein 2 (FABP4-UCP2) axis is a key regulator of neuroinflammation in high-fat-diet (HFD)-fed animals,…”
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Expression of uncoupling protein-2 remains increased within hibernating myocardium despite successful coronary artery bypass grafting at 4 wk post-revascularization by Holley, Christopher T., MD, Duffy, Cayla M., BS, Butterick, Tammy A., PhD, Long, Eric K., PhD, Lindsey, Megan E., BS, Cabrera, Jesús A., MD, PhD, Ward, Herbert B., MD, PhD, McFalls, Edward O., MD, PhD, Kelly, Rosemary F., MD

“…Abstract Background We have previously shown that mitochondrial uncoupling protein-2 (UCP-2) is increased in a swine model of hibernating myocardium (HM)…”
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Mitochondrial fusion proteins in revascularized hibernating hearts by Holley, Christopher T., MD, Long, Eric K., PhD, Butterick, Tammy A., PhD, Duffy, Cayla M., BS, Lindsey, Megan E., BS, Stone, Laura Hocum, PhD, McFalls, Edward O., MD, PhD, Kelly, Rosemary F., MD

“…Abstract Background Hibernating myocardium is characterized by viable yet dysfunctional myocardium secondary to chronic ischemia, with studies demonstrating…”
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Microglial Immune Response to Low Concentrations of Combustion-Generated Nanoparticles: An In Vitro Model of Brain Health by Duffy, Cayla M, Swanson, Jacob, Northrop, William, Nixon, Joshua P, Butterick, Tammy A

“…The brain is the central regulator for integration and control of responses to environmental cues. Previous studies suggest that air pollution may directly…”
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Orexin/hypocretin treatment restores hippocampal-dependent memory in orexin-deficient mice by Mavanji, Vijayakumar, Butterick, Tammy A., Duffy, Cayla M., Nixon, Joshua P., Billington, Charles J., Kotz, Catherine M.

“…•Orexin 1 receptor expression is elevated in mice lacking orexin (O/A3 mice).•O/A3 mice showed significant impairments in a two-way active avoidance memory…”
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Orexin A attenuates palmitic acid-induced hypothalamic cell death by Duffy, Cayla M., Nixon, Joshua P., Butterick, Tammy A.

“…Palmitic acid (PA), an abundant dietary saturated fatty acid, contributes to obesity and hypothalamic dysregulation in part through increase in oxidative…”
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Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity by Duffy, Cayla M, Ahmed, Shihab, Yuan, Ce, Mavanji, Vijayakumar, Nixon, Joshua P, Butterick, Tammy

“…Nanoparticles found in air pollutants can alter neurotransmitter profiles, increase neuroinflammation, and alter brain function. Therefore, the assay described…”
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Reduced expression of mitochondrial electron transport chain proteins from hibernating hearts relative to ischemic preconditioned hearts in the second window of protection by Cabrera, Jesús A, Butterick, Tammy A, Long, Eric K, Ziemba, Elizabeth A, Anderson, Lorraine B, Duffy, Cayla M, Sluiter, Willem, Duncker, Dirk J, Zhang, Jianyi, Chen, Yingjie, Ward, Herbert B, Kelly, Rosemary F, McFalls, Edward O

“…Abstract Although protection against necrosis has been observed in both hibernating (HIB) and ischemic preconditioned hearts in the second window of protection…”
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Use of a caspase multiplexing assay to determine apoptosis in a hypothalamic cell model by Butterick, Tammy A, Duffy, Cayla M, Lee, Rachel E, Billington, Charles J, Kotz, Catherine M, Nixon, Joshua P

“…The ability to multiplex assays in studies of complex cellular mechanisms eliminates the need for repetitive experiments, provides internal controls, and…”
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Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity by Duffy, Cayla M., Ahmed, Shihab, Yuan, Ce, Mavanji, Vijayakumar, Nixon, Joshua P., Butterick, Tammy

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Expression of Uncoupling Protein-2 Remains Increased Within Hibernating Myocardium Despite Successful Coronary Artery Bypass Grafting at 4 Weeks Post-Revascularization by Holley, Christopher T., Duffy, Cayla M., Butterick, Tammy A., Long, Eric K., Lindsey, Megan E., Cabrera, Jesús A., Ward, Herbert B., McFalls, Edward O., Kelly, Rosemary F.

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Use of a Caspase Multiplexing Assay to Determine Apoptosis in a Hypothalamic Cell Model by Butterick, Tammy A., Duffy, Cayla M., Lee, Rachel E., Billington, Charles J., Kotz, Catherine M., Nixon, Joshua P.

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