Search Results - "Duffy, Cayla"

Identification of a fatty acid binding protein4-UCP2 axis regulating microglial mediated neuroinflammation by Duffy, Cayla M., Xu, Hongliang, Nixon, Joshua P., Bernlohr, David A., Butterick, Tammy A.

“…Hypothalamic inflammation contributes to metabolic dysregulation and the onset of obesity. Dietary saturated fats activate microglia via a nuclear factor-kappa…”
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Orexin/hypocretin treatment restores hippocampal-dependent memory in orexin-deficient mice by Mavanji, Vijayakumar, Butterick, Tammy A., Duffy, Cayla M., Nixon, Joshua P., Billington, Charles J., Kotz, Catherine M.

“…•Orexin 1 receptor expression is elevated in mice lacking orexin (O/A3 mice).•O/A3 mice showed significant impairments in a two-way active avoidance memory…”
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Role of orexin A signaling in dietary palmitic acid-activated microglial cells by Duffy, Cayla M., Yuan, Ce, Wisdorf, Lauren E., Billington, Charles J., Kotz, Catherine M., Nixon, Joshua P., Butterick, Tammy A.

“…•Palmitic acid (PA) increases microglial orexin receptor 1 expression.•PA increases microglial pro-inflammatory cytokine release.•Orexin A reduces microglial…”
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Microglial FABP4-UCP2 Axis Modulates Neuroinflammation and Cognitive Decline in Obese Mice by So, Simon W, Fleming, Kendra M, Duffy, Cayla M, Nixon, Joshua P, Bernlohr, David A, Butterick, Tammy A

“…The microglial fatty-acid-binding protein 4-uncoupling protein 2 (FABP4-UCP2) axis is a key regulator of neuroinflammation in high-fat-diet (HFD)-fed animals,…”
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Orexin A attenuates palmitic acid-induced hypothalamic cell death by Duffy, Cayla M., Nixon, Joshua P., Butterick, Tammy A.

“…Palmitic acid (PA), an abundant dietary saturated fatty acid, contributes to obesity and hypothalamic dysregulation in part through increase in oxidative…”
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Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity by Duffy, Cayla M, Ahmed, Shihab, Yuan, Ce, Mavanji, Vijayakumar, Nixon, Joshua P, Butterick, Tammy

“…Nanoparticles found in air pollutants can alter neurotransmitter profiles, increase neuroinflammation, and alter brain function. Therefore, the assay described…”
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Microglial Immune Response to Low Concentrations of Combustion-Generated Nanoparticles: An In Vitro Model of Brain Health by Duffy, Cayla M, Swanson, Jacob, Northrop, William, Nixon, Joshua P, Butterick, Tammy A

“…The brain is the central regulator for integration and control of responses to environmental cues. Previous studies suggest that air pollution may directly…”
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Expression of uncoupling protein-2 remains increased within hibernating myocardium despite successful coronary artery bypass grafting at 4 wk post-revascularization by Holley, Christopher T., MD, Duffy, Cayla M., BS, Butterick, Tammy A., PhD, Long, Eric K., PhD, Lindsey, Megan E., BS, Cabrera, Jesús A., MD, PhD, Ward, Herbert B., MD, PhD, McFalls, Edward O., MD, PhD, Kelly, Rosemary F., MD

“…Abstract Background We have previously shown that mitochondrial uncoupling protein-2 (UCP-2) is increased in a swine model of hibernating myocardium (HM)…”
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Mitochondrial fusion proteins in revascularized hibernating hearts by Holley, Christopher T., MD, Long, Eric K., PhD, Butterick, Tammy A., PhD, Duffy, Cayla M., BS, Lindsey, Megan E., BS, Stone, Laura Hocum, PhD, McFalls, Edward O., MD, PhD, Kelly, Rosemary F., MD

“…Abstract Background Hibernating myocardium is characterized by viable yet dysfunctional myocardium secondary to chronic ischemia, with studies demonstrating…”
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Reduced expression of mitochondrial electron transport chain proteins from hibernating hearts relative to ischemic preconditioned hearts in the second window of protection by Cabrera, Jesús A, Butterick, Tammy A, Long, Eric K, Ziemba, Elizabeth A, Anderson, Lorraine B, Duffy, Cayla M, Sluiter, Willem, Duncker, Dirk J, Zhang, Jianyi, Chen, Yingjie, Ward, Herbert B, Kelly, Rosemary F, McFalls, Edward O

“…Abstract Although protection against necrosis has been observed in both hibernating (HIB) and ischemic preconditioned hearts in the second window of protection…”
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Use of a caspase multiplexing assay to determine apoptosis in a hypothalamic cell model by Butterick, Tammy A, Duffy, Cayla M, Lee, Rachel E, Billington, Charles J, Kotz, Catherine M, Nixon, Joshua P

“…The ability to multiplex assays in studies of complex cellular mechanisms eliminates the need for repetitive experiments, provides internal controls, and…”
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RNAseq Analysis of FABP4 Knockout Hippocampal Transcriptome in Obese Mice by So, Simon, Roe, David, Fleming, Kendra, Duffy, Cayla, Nixon, Joshua, Bernlohr, David, Butterick, Tammy

“…Background: Obesity and associated comorbidities such as metabolic syndrome and diabetes are known risk factors for cognitive impairment and the development of…”
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High Fat Diet Increases Cognitive Decline and Neuroinflammation in a Model of Orexin Loss by Duffy, Cayla Marie, Nixon, Joshua P, Butterick, Tammy A

“…Abstract only Midlife obesity is a risk factor for cognitive decline and is associated with the earlier onset of Alzheimer's disease (AD). Diets high in…”
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Abstract 10277: Effect of CoQ10 on Contractile Reserve of Hibernating Swine Myocardium Following Bypass Surgery by Hocum Stone, Laura, Duffy, Cayla, Butterick, Tammy A, Holley, Christopher, Crampton, Melanie, Ward, Herbert B, Swingen, Corey, Kelly, Rosemary F, McFalls, Edward O

“…BackgroundWe have previously shown that the recovery of regional function and maximal oxygen consumption in a pig model of hibernating myocardium is incomplete…”
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Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity by Duffy, Cayla M., Ahmed, Shihab, Yuan, Ce, Mavanji, Vijayakumar, Nixon, Joshua P., Butterick, Tammy

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Pioglitazone increases PGC1-α signaling within chronically ischemic myocardium by Butterick, Tammy A., Hocum Stone, Laura, Duffy, Cayla, Holley, Christopher, Cabrera, Jesús A., Crampton, Melanie, Ward, Herbert B., Kelly, Rosemary F., McFalls, Edward O.

“…The peroxisome proliferator-activated receptor (PPAR)-γ drug pioglitazone (PIO) has been shown to protect tissue against oxidant stress. In a swine model of…”
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Pioglitazone increases PGC1-[alpha] signaling within chronically ischemic myocardium by Butterick, Tammy A, Hocum Stone, Laura, Duffy, Cayla, Holley, Christopher, Cabrera, Jesús A, Crampton, Melanie, Ward, Herbert B, Kelly, Rosemary F, Mcfalls, Edward O

“…The peroxisome proliferator-activated receptor (PPAR)-γ drug pioglitazone (PIO) has been shown to protect tissue against oxidant stress. In a swine model of…”
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Abstract 9959: Chronic Administration of Pioglitazone and Pro-Oxidant Effects Within Chronic Hibernating Pig Hearts by Butterick, Tammy A, Long, Eric K, Duffy, Cayla, Cabrera, Jesús A, Holley, Christopher T, Ward, Herbert B, Kelly, Rosemary F, McFalls, Edward O

“…Abstract only Background: Glitazones have pleomorphic effects on myocardial metabolism. We hypothesized that the PPAR-gamma agent pioglitazone (PIO) would…”
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Abstract 9841: Expression of Mitochondrial Fusion Proteins is Increased in Hibernating Hearts Following Bypass Surgery by Long, Eric K, Butterick, Tammy A, Duffy, Cayla, Cabrera, Jesús A, Lindsey, Meghan, Holley, Christopher T, Ward, Herbert B, McFalls, Edward O, Kelly, Rosemary F

“…Abstract only Background: Based on clinical studies, regional function within hibernating myocardium may not return to normal immediately following successful…”
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Diet Induced Neuroinflammation and Cognitive Decline by Duffy, Cayla Marie

“…The prevalence of obesity in the U.S. is over 50%, and midlife obesity is a clinical risk factor for cognitive impairment and the onset of neurodegenerative…”
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