Search Results - "Duffull, S. B."

Warfarin Dosing Algorithms Underpredict Dose Requirements in Patients Requiring ≥7 mg Daily: A Systematic Review and Meta‐analysis by Saffian, SM, Duffull, SB, Wright, DFB

“…There is preliminary evidence to suggest that some published warfarin dosing algorithms produce biased maintenance dose predictions in patients who require…”
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Systematic Comparison of the Population Pharmacokinetics and Pharmacodynamics of Piperacillin in Cystic Fibrosis Patients and Healthy Volunteers by BULITTA, J. B, DUFFULL, S. B, KINZIG-SCHIPPERS, M, HOLZGRABE, U, STEPHAN, U, DRUSANO, G. L, SÖRGEL, F

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A framework for quantifying the influence of adherence and dose individualization by Assawasuwannakit, P, Braund, R, Duffull, SB

“…A failure to accommodate for a patient's imperfect adherence may result in therapeutic failure. Similarly, failure to accommodate a patient's individual needs…”
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Failure of antivenom to improve recovery in Australian snakebite coagulopathy by Isbister, G.K., Duffull, S.B., Brown, S.G.A.

“…Background: Venom-induced consumption coagulopathy (VICC) is an important feature of snake envenoming. Aim: To investigate the effect of antivenom and fresh…”
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A Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics by Duffull, SB

“…The framework for systems pharmacology style models does not naturally sit with the usual scientific dogma of parsimony and falsifiability based on deductive…”
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A Population Pharmacokinetic and Pharmacodynamic Evaluation of Pralatrexate in Patients With Relapsed or Refractory Non-Hodgkin's or Hodgkin's Lymphoma by Mould, DR, Sweeney, K, Duffull, SB, Neylon, E, Hamlin, P, Horwitz, S, Sirotnak, F, Fleisher, M, Saunders, ME, O'Connor, OA

“…In a pralatrexate phase I study, patients displayed a high incidence of mucositis of grades 3 and 4. Preliminary evaluations of the pharmacokinetics of the…”
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Quantification of the Forgiveness of Drugs to Imperfect Adherence by Assawasuwannakit, P, Braund, R, Duffull, SB

“…The circumstance of how sensitive therapeutic success is under imperfect adherence is driven by the property known as forgiveness. To date, no studies have…”
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Individualized Compared With Conventional Dosing of Enoxaparin by Barras, MA, Duffull, SB, Atherton, JJ, Green, B

“…The aim of this study was to compare an individualized dosing regimen for enoxaparin to conventional dosing. Patients in the individualized arm were initially…”
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Pharmacokinetics of Quetiapine in Overdose and the Effect of Activated Charcoal by Isbister, G K, Friberg, L E, Hackett, L P, Duffull, S B

“…The aim of the study was to investigate the pharmacokinetics of quetiapine overdose and the effect of charcoal. The data set included 204 concentration–time…”
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A Comprehensive Model for the Humoral Coagulation Network in Humans by WAJIMA, T, ISBISTER, G. K, DUFFULL, S. B

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A learning-based approach for performing an in-depth literature search using MEDLINE by Young, S., Duffull, S. B.

“…Summary What is known and objective:  Exhaustive literature searching is a core requirement for developing guidelines for evidence‐based practice. MEDLINE is…”
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Prediction of Torsade de Pointes From the QT Interval: Analysis of a Case Series of Amisulpride Overdoses by Joy, JP, Coulter, CV, Duffull, SB, Isbister, GK

“…Electrocardiograms (ECGs) from a case series of 86 amisulpride overdose events in 66 patients were reviewed for abnormal QT intervals and torsade de pointes…”
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Population pharmacokinetic analysis of mycophenolic acid in renal transplant recipients following oral administration of mycophenolate mofetil by Shum, B., Duffull, S. B., Taylor, P. J., Tett, S. E.

“…Aim  To develop a population pharmacokinetic model for mycophenolic acid in adult kidney transplant recipients, quantifying average population pharmacokinetic…”
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A model for venom-induced consumptive coagulopathy in snake bite by Tanos, P.P., Isbister, G.K., Lalloo, D.G., Kirkpatrick, C.M.J., Duffull, S.B.

“…Many snake venoms contain procoagulant toxins that activate the coagulation cascade and cause venom-induced consumptive coagulopathy (VICC). We developed a…”
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Promethazine overdose: clinical effects, predicting delirium and the effect of charcoal by Page, C.B., Duffull, S.B., Whyte, I.M., Isbister, G.K.

“…Objective: The aim of this study was to describe the clinical effects of promethazine in overdose and explore the relationship between delirium and possible…”
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An Approach for Identifiability of Population Pharmacokinetic–Pharmacodynamic Models by Shivva, V, Korell, J, Tucker, IG, Duffull, SB

“…Mathematical models are routinely used in clinical pharmacology to study the pharmacokinetic and pharmacodynamic properties of a drug in the body…”
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The Effect of Decontamination Procedures on the Pharmacokinetics of Venlafaxine in Overdose by Kumar, V V P, Oscarsson, S, Friberg, L E, Isbister, G K, Hackett, L P, Duffull, S B

“…The aim of this work was to investigate the pharmacokinetics (PK) of venlafaxine in overdose and the effects of single‐dose activated charcoal (SDAC) and…”
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Scale Reduction of a Systems Coagulation Model With an Application to Modeling Pharmacokinetic–Pharmacodynamic Data by Gulati, A, Isbister, GK, Duffull, SB

“…Bridging systems biology and pharmacokinetics–pharmacodynamics has resulted in models that are highly complex and complicated. They usually contain large…”
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Design of experiments for bivariate binary responses modelled by Copula functions by Denman, N.G., McGree, J.M., Eccleston, J.A., Duffull, S.B.

“…Optimal design for generalized linear models has primarily focused on univariate data. Often experiments are performed that have multiple dependent responses…”
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A Comprehensive Model for the Humoral Coagulation Network in Humans by Wajima, T, Isbister, G K, Duffull, S B

“…Coagulation is an important process in hemostasis and comprises a complicated interaction of multiple enzymes and proteins. We have developed a mechanistic…”
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